Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides
Kasuya, Takeshi, Hori, Shin-ichiro, Watanabe, Ayahisa, Nakajima, Mado, Gahara, Yoshinari, Rokushima, Masatomo, Yanagimoto, Toru, Kugimiya, Akira
Published in Scientific reports (27.07.2016)
Published in Scientific reports (27.07.2016)
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Journal Article
Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region
Nakajima, Mado, Kasuya, Takeshi, Yokota, Shinnichi, Onishi, Reina, Ikehara, Tatsuya, Kugimiya, Akira, Watanabe, Ayahisa
Published in Nucleic acid therapeutics (01.08.2017)
Published in Nucleic acid therapeutics (01.08.2017)
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Journal Article
Asymmetric synthesis of 3-azide-4-fluoro-l-phenylalanine
Adachi, Masaatsu, Nakajima, Mado, Isobe, Minoru
Published in Bioscience, biotechnology, and biochemistry (04.05.2015)
Published in Bioscience, biotechnology, and biochemistry (04.05.2015)
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Journal Article
Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins
ONISHI, Reina, WATANABE, Ayahisa, NAKAJIMA, Mado, SEKIGUCHI, Mitsuaki, KUGIMIYA, Akira, KINOUCHI, Hiroki, NIHASHI, Yoichiro, KAMIMORI, Hiroshi
Published in Analytical Sciences (2015)
Published in Analytical Sciences (2015)
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Journal Article
Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV‑1 Protease Inhibitors Using the Ligand Binding Pocket as a Template
Kojima, Eiichi, Iimuro, Atsuhiro, Nakajima, Mado, Kinuta, Hirotaka, Asada, Naoya, Sako, Yusuke, Nakata, Zenzaburo, Uemura, Kentaro, Arita, Shuhei, Miki, Shinobu, Wakasa-Morimoto, Chiaki, Tachibana, Yuki
Published in Journal of medicinal chemistry (28.04.2022)
Published in Journal of medicinal chemistry (28.04.2022)
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Journal Article
Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Kamiyama, Akane, Nakajima, Mado, Han, Liyou, Wada, Kei, Mizutani, Masaharu, Tabuchi, Yukiko, Kojima-Yuasa, Akiko, Matsui-Yuasa, Isao, Suzuki, Hideyuki, Fukuyama, Keiichi, Watanabe, Bunta, Hiratake, Jun
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Journal Article
Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B
Watanabe, Ayahisa, Nakajima, Mado, Kasuya, Takeshi, Onishi, Reina, Kitade, Naohisa, Mayumi, Kei, Ikehara, Tatsuya, Kugimiya, Akira
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
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Journal Article
Glutathione-analogous peptidyl phosphorus esters as mechanism-based inhibitors of γ-glutamyl transpeptidase for probing cysteinyl-glycine binding site
Nakajima, Mado, Watanabe, Bunta, Han, Liyou, Shimizu, Bun-ichi, Wada, Kei, Fukuyama, Keiichi, Suzuki, Hideyuki, Hiratake, Jun
Published in Bioorganic & medicinal chemistry (01.02.2014)
Published in Bioorganic & medicinal chemistry (01.02.2014)
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Journal Article
CONDENSED HETEROCYCLIC COMPOUND
NAKAO, Moemi, NAGAI, Hiroshi, KAMAURA, Masahiro, INABA, Yusuke, NAKAJIMA, Mado, TAKAYA, Kenji, KUROSE, Noriyuki, SHINTANI, Yusuke, KUWANO, Yuki
Year of Publication 21.10.2021
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Year of Publication 21.10.2021
Patent
OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY
MASUDA, KOUJI, KATO, TERUKAZU, KIDA, SHIRO, YONEHARA, MITSUHIRO, KOJIMA, EIICHI, YOSHIKAWA, NAOKI, NAKAJIMA, MADO, KATOU, MANABU
Year of Publication 23.06.2011
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Year of Publication 23.06.2011
Patent
ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON VASCULAR ENDOTHELIAL LIPASE
HAYASHI, KYOHEI, KUGIMIYA, AKIRA, MASUDA, KOUJI, KIDA, SHIRO, YOSHIKAWA, NAOKI, NAKAJIMA, MADO, KATOU, MANABU, TANAKA, NOBUYUKI
Year of Publication 22.04.2010
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Year of Publication 22.04.2010
Patent
SPIRO DERIVATIVE HAVING GPR119 AGONIST ACTIVITY
TANAKA, SATORU, MASUDA, KOJI, KATO, TERUKAZU, KIDA, SHIRO, YARI, HIROSHI, YONEHARA, MITSUHIRO, WADA, TOSHIHIRO, OKANO, AZUSA, NAKAJIMA, MADO, WATANABE, KANA, OGAWA, TOMOYUKI
Year of Publication 14.06.2012
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Year of Publication 14.06.2012
Patent
CONDENSED HETEROCYCLIC COMPOUND
NAKAO, Moemi, NAGAI, Hiroshi, KAMAURA, Masahiro, INABA, Yusuke, NAKAJIMA, Mado, TAKAYA, Kenji, KUROSE, Noriyuki, SHINTANI, Yusuke, KUWANO, Yuki
Year of Publication 23.10.2024
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Year of Publication 23.10.2024
Patent
CONDENSED HETEROCYCLIC COMPOUND
NAKAO, Moemi, NAGAI, Hiroshi, KAMAURA, Masahiro, INABA, Yusuke, NAKAJIMA, Mado, TAKAYA, Kenji, KUROSE, Noriyuki, SHINTANI, Yusuke, KUWANO, Yuki
Year of Publication 21.03.2024
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Year of Publication 21.03.2024
Patent
CONDENSED HETEROCYCLIC COMPOUND
NAKAO, Moemi, NAGAI, Hiroshi, KAMAURA, Masahiro, INABA, Yusuke, NAKAJIMA, Mado, TAKAYA, Kenji, KUROSE, Noriyuki, SHINTANI, Yusuke, KUWANO, Yuki
Year of Publication 02.08.2023
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Year of Publication 02.08.2023
Patent
Condensed heterocyclic compound
TAKAYA, KENJI, SHINTANI, YUSUKE, KAMAURA, MASAHIRO, INABA, YUSUKE, NAKAO, MOEMI, KUWANO, YUKI, NAGAI, HIROSHI, KUROSE, NORIYUKI, NAKAJIMA, MADO
Year of Publication 01.02.2022
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Year of Publication 01.02.2022
Patent
OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY
MASUDA, KOJI, KATO, TERUKAZU, KIDA, SHIRO, YONEHARA, MITSUHIRO, KOJIMA, EIICHI, YOSHIKAWA, NAOKI, NAKAJIMA, MADO, KATOU, MANABU
Year of Publication 25.02.2015
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Year of Publication 25.02.2015
Patent
Acetic acid amide derivative having inhibitory activity on endothelial lipase
KUGIMIYA AKIRA, HAYASHI KYOHEI, TANAKA NOBUYUKI, KIDA SHIRO, KATOU MANABU, NAKAJIMA MADO, MASUDA KOJI, YOSHIKAWA NAOKI
Year of Publication 17.02.2015
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Year of Publication 17.02.2015
Patent