TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
Carreca, Anna P., Pravatà, Veronica M., Markham, Matthew, Bonelli, Simone, Murphy, Gillian, Nagase, Hideaki, Troeberg, Linda, Scilabra, Simone D.
Published in Scientific reports (21.07.2020)
Published in Scientific reports (21.07.2020)
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Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes
Ismail, Heba M., Yamamoto, Kazuhiro, Vincent, Tonia L., Nagase, Hideaki, Troeberg, Linda, Saklatvala, Jeremy
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2015)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2015)
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Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice
Seubert, Bastian, Grünwald, Barbara, Kobuch, Julia, Cui, Haissi, Schelter, Florian, Schaten, Susanne, Siveke, Jens T., Lim, Ngee H., Nagase, Hideaki, Simonavicius, Nicole, Heikenwalder, Mathias, Reinheckel, Thomas, Sleeman, Jonathan P., Janssen, Klaus‐Peter, Knolle, Percy A., Krüger, Achim
Published in Hepatology (Baltimore, Md.) (01.01.2015)
Published in Hepatology (Baltimore, Md.) (01.01.2015)
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Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1
Manka, Szymon W, Carafoli, Federico, Visse, Robert, Bihan, Dominique, Raynal, Nicolas, Farndale, Richard W, Murphy, Gillian, Enghild, Jan J, Hohenester, Erhard, Nagase, Hideaki
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2012)
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Tissue inhibitors of metalloproteinases: evolution, structure and function
Brew, Keith, Dinakarpandian, Deendayal, Nagase, Hideaki
Published in Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology (07.03.2000)
Published in Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology (07.03.2000)
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Book Review
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Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
Santamaria, Salvatore, Yamamoto, Kazuhiro, Botkjaer, Kenneth, Tape, Christopher, Dyson, Michael R, McCafferty, John, Murphy, Gillian, Nagase, Hideaki
Published in Biochemical journal (01.11.2015)
Published in Biochemical journal (01.11.2015)
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In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy
Duro‐Castano, Aroa, Lim, Ngee Han, Tranchant, Isabelle, Amoura, Mehdi, Beau, Fabrice, Wieland, Heike, Kingler, Otmar, Herrmann, Matthias, Nazaré, Marc, Plettenburg, Oliver, Dive, Vincent, Vicent, María J., Nagase, Hideaki
Published in Advanced functional materials (12.09.2018)
Published in Advanced functional materials (12.09.2018)
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The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer
Watanabe, Kenta, Hirata, Michiko, Tominari, Tsukasa, Matsumoto, Chiho, Fujita, Hidenori, Yonekura, Kazuhiko, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki
Published in The Journal of biological chemistry (30.09.2016)
Published in The Journal of biological chemistry (30.09.2016)
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Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1
Scilabra, Simone D., Troeberg, Linda, Yamamoto, Kazuhiro, Emonard, Hervé, Thøgersen, Ida, Enghild, Jan J., Strickland, Dudley K., Nagase, Hideaki
Published in The Journal of biological chemistry (04.01.2013)
Published in The Journal of biological chemistry (04.01.2013)
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TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)
Kashiwagi, M, Tortorella, M, Nagase, H, Brew, K
Published in The Journal of biological chemistry (20.04.2001)
Published in The Journal of biological chemistry (20.04.2001)
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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Durigova, Michaela, Nagase, Hideaki, Mort, John S., Roughley, Peter J.
Published in Matrix biology (01.03.2011)
Published in Matrix biology (01.03.2011)
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Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue
Scilabra, Simone D., Yamamoto, Kazuhiro, Pigoni, Martina, Sakamoto, Kazuma, Müller, Stephan A., Papadopoulou, Alkmini, Lichtenthaler, Stefan F., Troeberg, Linda, Nagase, Hideaki, Kadomatsu, Kenji
Published in Matrix biology (01.05.2017)
Published in Matrix biology (01.05.2017)
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Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity
Poulet, Blandine, Liu, Ke, Plumb, Darren, Vo, Phoung, Shah, Mittal, Staines, Katherine, Sampson, Alexandra, Nakamura, Hiroyuki, Nagase, Hideaki, Carriero, Alessandra, Shefelbine, Sandra, Pitsillides, Andrew A, Bou-Gharios, George
Published in PloS one (21.12.2016)
Published in PloS one (21.12.2016)
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Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
Watanabe, Kenta, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Hirata, Junya, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki
Published in FEBS open bio (01.08.2017)
Published in FEBS open bio (01.08.2017)
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Carcinomas Contain a Matrix Metalloproteinase-Resistant Isoform of Type I Collagen Exerting Selective Support to Invasion
MAKAREEVA, Elena, SEJIN HAN, VERA, Juan Carlos, SACKETT, Dan L, HOLMBECK, Kenn, PHILLIPS, Charlotte L, VISSE, Robert, NAGASE, Hideaki, LEIKIN, Sergey
Published in Cancer research (Chicago, Ill.) (01.06.2010)
Published in Cancer research (Chicago, Ill.) (01.06.2010)
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Functional Differences of the Catalytic and Non-catalytic Domains in Human ADAMTS-4 and ADAMTS-5 in Aggrecanolytic Activity
Fushimi, Kazunari, Troeberg, Linda, Nakamura, Hiroyuki, Lim, Ngee Han, Nagase, Hideaki
Published in The Journal of biological chemistry (14.03.2008)
Published in The Journal of biological chemistry (14.03.2008)
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