Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Hayashi, Takahiko, Suzuki, Hiroko, Nishida, Masahiro, Arai, Hirokazu
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
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Journal Article
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP 1 receptor antagonist and in vivo studies in a bone fracture model
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Hayashi, Takahiko, Suzuki, Hiroko, Nishida, Masahiro, Arai, Hirokazu
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
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Journal Article
Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP1 receptor antagonists for treatment of overactive bladder by core structure replacement
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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Journal Article
SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists
Atobe, Masakazu, Naganuma, Kenji, Kawanishi, Masashi, Morimoto, Akifumi, Kasahara, Ken-ichi, Ohashi, Shigeki, Suzuki, Hiroko, Hayashi, Takahiko, Miyoshi, Shiro
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Journal Article