NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF NOVEL 4,5-DIHYDRO-4-OXO-3H-IMIDAZO[4,5-C]PYRIDINE DERIVATIVES
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The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers
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Novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT(1) and AT(2) subtypes
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Published in European journal of medicinal chemistry (01.06.1997)
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The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer"
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Published in Journal of cardiovascular pharmacology (01.07.1991)
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Novel 4,5-dihydro-4-oxo-3 H-imidazo[4,5- c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT 1 and AT 2 subtypes
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Published in European journal of medicinal chemistry (1997)
Published in European journal of medicinal chemistry (1997)
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Non-Peptide Angiotensin II Receptor Antagonists: Synthesis and Biological Activity of a Series of Novel 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridine Derivatives
Mederski, Werner W. K. R, Dorsch, Dieter, Bokel, Heinz-Hermann, Beier, Norbert, Lues, Ingeborg, Schelling, Pierre
Published in Journal of medicinal chemistry (01.05.1994)
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A novel thiadiazinone increases the acto-myosin interaction
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Uracil-based angiotensin II receptor antagonists
Dorsch, Dieter, Mederski, Werner W.K.R., Osswald, Mathias, Beier, Norbert, Schelling, Pierre
Published in Bioorganic & medicinal chemistry letters (21.09.1995)
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Trong, Hai Le, Beier, Norbert, Sonnenburg, William K, Stroop, Steven D, Walsh, Kenneth A, Beavo, Joseph A, Charbonneau, Harry
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Novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes
MEDERSKI, W. W. K. R, DORSCH, D, OSSWALD, M, SCHWARTZ, H, BEIER, N, CHRISTADLER, M, MINCK, K. O, SCHELLING, P, SCHMITGES, C. J
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A SVAT scheme for NO, NO sub(2) , and O sub(3) Amodel description and test results
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SYNTHESIS OF 7-ETHYL-1,2-DIHYDROQUINOLIN-2-ONES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS
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Published in Heterocycles (31.12.1994)
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Myofilament effects of a novel thiadiazinone in the canine heart
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3-Substituted 6-butyl-1,2-dihydropyridin-2-ones: A new series of potent nonpeptide angiotensin II receptor antagonists
Osswald, Mathias, Mederski, Werner W.K.R., Schwarz, Michael, Beier, Norbert, Lues, Ingeborg, Minck, Klaus-Otto
Published in Bioorganic & medicinal chemistry letters (10.03.1994)
Published in Bioorganic & medicinal chemistry letters (10.03.1994)
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The two mechanisms of action of the racemic cardiotonic EMD 53 998, Ca-sensitization and PDE-inhibition, reside in different enantiomers
Beier, Norbert, Jonas, Rochus, Klockow, Michael, Lues, Inge, Wolf, Hans-P.
Published in Journal of molecular and cellular cardiology (01.07.1991)
Published in Journal of molecular and cellular cardiology (01.07.1991)
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