H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models
Haase, Santiago, Banerjee, Kaushik, Mujeeb, Anzar A, Hartlage, Carson S, Núñez, Fernando M, Núñez, Felipe J, Alghamri, Mahmoud S, Kadiyala, Padma, Carney, Stephen, Barissi, Marcus N, Taher, Ayman W, Brumley, Emily K, Thompson, Sarah, Dreyer, Justin T, Alindogan, Caitlin T, Garcia-Fabiani, Maria B, Comba, Andrea, Venneti, Sriram, Ravikumar, Visweswaran, Koschmann, Carl, Carcaboso, Ángel M, Vinci, Maria, Rao, Arvind, Yu, Jennifer S, Lowenstein, Pedro R, Castro, Maria G
Published in The Journal of clinical investigation (15.11.2022)
Published in The Journal of clinical investigation (15.11.2022)
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IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
Núñez, Felipe J, Mendez, Flor M, Kadiyala, Padma, Alghamri, Mahmoud S, Savelieff, Masha G, Garcia-Fabiani, Maria B, Haase, Santiago, Koschmann, Carl, Calinescu, Anda-Alexandra, Kamran, Neha, Saxena, Meghna, Patel, Rohin, Carney, Stephen, Guo, Marissa Z, Edwards, Marta, Ljungman, Mats, Qin, Tingting, Sartor, Maureen A, Tagett, Rebecca, Venneti, Sriram, Brosnan-Cashman, Jacqueline, Meeker, Alan, Gorbunova, Vera, Zhao, Lili, Kremer, Daniel M, Zhang, Li, Lyssiotis, Costas A, Jones, Lindsey, Herting, Cameron J, Ross, James L, Hambardzumyan, Dolores, Hervey-Jumper, Shawn, Figueroa, Maria E, Lowenstein, Pedro R, Castro, Maria G
Published in Science translational medicine (13.02.2019)
Published in Science translational medicine (13.02.2019)
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Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses
Comba, Andrea, Dunn, Patrick J, Argento, Anna E, Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel B, Núñez, Felipe J, Zhao, Lili, Castro, Maria G, Lowenstein, Pedro R
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
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Journal Article
Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease
Mendez, Flor M, Núñez, Felipe J, Garcia-Fabiani, Maria B, Haase, Santiago, Carney, Stephen, Gauss, Jessica C, Becher, Oren J, Lowenstein, Pedro R, Castro, Maria G
Published in Neuro-oncology (Charlottesville, Va.) (20.02.2020)
Published in Neuro-oncology (Charlottesville, Va.) (20.02.2020)
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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Núñez, Felipe J, Mendez, Flor M, Garcia-Fabiani, Maria B, Pardo, Joaquín, Edwards, Marta, Lowenstein, Pedro R, Castro, Maria G
Published in Journal of visualized experiments (09.01.2019)
Published in Journal of visualized experiments (09.01.2019)
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Journal Article
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice
Kadiyala, Padma, Carney, Stephen V, Gauss, Jessica C, Garcia-Fabiani, Maria B, Haase, Santiago, Alghamri, Mahmoud S, Núñez, Felipe J, Liu, Yayuan, Yu, Minzhi, Taher, Ayman, Nunez, Fernando M, Li, Dan, Edwards, Marta B, Kleer, Celina G, Appelman, Henry, Sun, Yilun, Zhao, Lili, Moon, James J, Schwendeman, Anna, Lowenstein, Pedro R, Castro, Maria G
Published in The Journal of clinical investigation (15.02.2021)
Published in The Journal of clinical investigation (15.02.2021)
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Journal Article
Mutant ATRX: uncovering a new therapeutic target for glioma
Haase, Santiago, Garcia-Fabiani, María Belén, Carney, Stephen, Altshuler, David, Núñez, Felipe J, Méndez, Flor M, Núñez, Fernando, Lowenstein, Pedro R, Castro, Maria G
Published in Expert opinion on therapeutic targets (03.07.2018)
Published in Expert opinion on therapeutic targets (03.07.2018)
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ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
Koschmann, Carl, Calinescu, Anda-Alexandra, Nunez, Felipe J, Mackay, Alan, Fazal-Salom, Janet, Thomas, Daniel, Mendez, Flor, Kamran, Neha, Dzaman, Marta, Mulpuri, Lakshman, Krasinkiewicz, Johnathon, Doherty, Robert, Lemons, Rosemary, Brosnan-Cashman, Jacqueline A, Li, Youping, Roh, Soyeon, Zhao, Lili, Appelman, Henry, Ferguson, David, Gorbunova, Vera, Meeker, Alan, Jones, Chris, Lowenstein, Pedro R, Castro, Maria G
Published in Science translational medicine (02.03.2016)
Published in Science translational medicine (02.03.2016)
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Journal Article
Current Approaches for Glioma Gene Therapy and Virotherapy
Banerjee, Kaushik, Núñez, Felipe J, Haase, Santiago, McClellan, Brandon L, Faisal, Syed M, Carney, Stephen V, Yu, Jin, Alghamri, Mahmoud S, Asad, Antonela S, Candia, Alejandro J Nicola, Varela, Maria Luisa, Candolfi, Marianela, Lowenstein, Pedro R, Castro, Maria G
Published in Frontiers in molecular neuroscience (11.03.2021)
Published in Frontiers in molecular neuroscience (11.03.2021)
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The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas
Gargini, Ricardo, Segura-Collar, Berta, Herránz, Beatriz, García-Escudero, Vega, Romero-Bravo, Andrés, Núñez, Felipe J, García-Pérez, Daniel, Gutiérrez-Guamán, Jacqueline, Ayuso-Sacido, Angel, Seoane, Joan, Pérez-Núñez, Angel, Sepúlveda-Sánchez, Juan M, Hernández-Laín, Aurelio, Castro, María G, García-Escudero, Ramón, Ávila, Jesús, Sánchez-Gómez, Pilar
Published in Science translational medicine (22.01.2020)
Published in Science translational medicine (22.01.2020)
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The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors
Lubieniecki, Fabiana, Vazquez, Valeria, Lamas, Gabriela S., Camarero, Sandra, Nuñez, Felipe J., Baroni, Lorena, Schüller, Ulrich, Alderete, Daniel
Published in Child's nervous system (01.02.2023)
Published in Child's nervous system (01.02.2023)
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Journal Article
Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Carney, Stephen V, Banerjee, Kaushik, Mujeeb, Anzar, Zhu, Brandon, Haase, Santiago, Varela, Maria L, Kadiyala, Padma, Tronrud, Claire E, Zhu, Ziwen, Mukherji, Devarshi, Gorla, Preethi, Sun, Yilun, Tagett, Rebecca, Núñez, Felipe J, Luo, Maowu, Luo, Weibo, Ljungman, Mats, Liu, Yayuan, Xia, Ziyun, Schwendeman, Anna, Qin, Tingting, Sartor, Maureen A, Costello, Joseph F, Cahill, Daniel P, Lowenstein, Pedro R, Castro, Maria G
Published in Clinical cancer research (01.05.2023)
Published in Clinical cancer research (01.05.2023)
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Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
Comba, Andrea, Faisal, Syed M., Varela, Maria Luisa, Hollon, Todd, Al-Holou, Wajd N., Umemura, Yoshie, Nunez, Felipe J., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.
Published in Frontiers in oncology (05.08.2021)
Published in Frontiers in oncology (05.08.2021)
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Functional characterization of tumor antigen-specific T-cells isolated from the tumor microenvironment of sleeping beauty induced murine glioma models
Alghamri, Mahmoud S, Núñez, Felipe J, Kamran, Neha, Carney, Stephen, Altshuler, David, Lowenstein, Pedro R, Castro, Maria G
Published in Methods in enzymology (01.01.2020)
Published in Methods in enzymology (01.01.2020)
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Prospects of biological and synthetic pharmacotherapies for glioblastoma
Altshuler, David B, Kadiyala, Padma, Nuñez, Felipe J, Nuñez, Fernando M, Carney, Stephen, Alghamri, Mahmoud S, Garcia-Fabiani, Maria B, Asad, Antonela S, Nicola Candia, Alejandro J, Candolfi, Marianela, Lahann, Joerg, Moon, James J, Schwendeman, Anna, Lowenstein, Pedro R, Castro, Maria G
Published in Expert opinion on biological therapy (03.03.2020)
Published in Expert opinion on biological therapy (03.03.2020)
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G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy
Alghamri, Mahmoud S, McClellan, Brandon L, Avvari, Ruthvik P, Thalla, Rohit, Carney, Stephen, Hartlage, Carson S, Haase, Santiago, Ventosa, Maria, Taher, Ayman, Kamran, Neha, Zhang, Li, Faisal, Syed Mohd, Núñez, Felipe J, Garcia-Fabiani, María Belén, Al-Holou, Wajd N, Orringer, Daniel, Hervey-Jumper, Shawn, Heth, Jason, Patil, Parag G, Eddy, Karen, Merajver, Sofia D, Ulintz, Peter J, Welch, Joshua, Gao, Chao, Liu, Jialin, Núñez, Gabriel, Hambardzumyan, Dolores, Lowenstein, Pedro R, Castro, Maria G
Published in Science advances (01.10.2021)
Published in Science advances (01.10.2021)
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Journal Article
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
Garcia-Fabiani, Maria B., Haase, Santiago, Comba, Andrea, Carney, Stephen, McClellan, Brandon, Banerjee, Kaushik, Alghamri, Mahmoud S., Syed, Faisal, Kadiyala, Padma, Nunez, Felipe J., Candolfi, Marianela, Asad, Antonela, Gonzalez, Nazareno, Aikins, Marisa E., Schwendeman, Anna, Moon, James J., Lowenstein, Pedro R., Castro, Maria G.
Published in Frontiers in oncology (08.06.2021)
Published in Frontiers in oncology (08.06.2021)
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Journal Article
Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres
Mendez, Flor M, Núñez, Felipe J, Zorrilla-Veloz, Rocío I, Lowenstein, Pedro R, Castro, Maria G
Published in Journal of visualized experiments (29.01.2018)
Published in Journal of visualized experiments (29.01.2018)
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