Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain
Svarcbahs, Reinis, Julku, Ulrika H, Myöhänen, Timo T
Published in The Journal of neuroscience (07.12.2016)
Published in The Journal of neuroscience (07.12.2016)
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Deletion or inhibition of prolyl oligopeptidase blocks lithium‐induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A
Myöhänen, Timo T., Mertens, Freke, Norrbacka, Susanna, Cui, Hengjing
Published in Basic & clinical pharmacology & toxicology (01.10.2021)
Published in Basic & clinical pharmacology & toxicology (01.10.2021)
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5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Pätsi, Henri T., Kilpeläinen, Tommi P., Jumppanen, Mikael, Uhari-Väänänen, Johanna, Wielendaele, Pieter Van, De Lorenzo, Francesca, Cui, Hengjing, Auno, Samuli, Saharinen, Janne, Seppälä, Erin, Sipari, Nina, Savinainen, Juha, De Meester, Ingrid, Lambeir, Anne-Marie, Lahtela-Kakkonen, Maija, Myöhänen, Timo T., Wallén, Erik A. A.
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo
Svarcbahs, Reinis, Julku, Ulrika H, Norrbacka, Susanna, Myöhänen, Timo T
Published in Scientific reports (24.01.2018)
Published in Scientific reports (24.01.2018)
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Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A
Svarcbahs, Reinis, Jäntti, Maria, Kilpeläinen, Tommi, Julku, Ulrika H., Urvas, Lauri, Kivioja, Saara, Norrbacka, Susanna, Myöhänen, Timo T.
Published in Pharmacological research (01.01.2020)
Published in Pharmacological research (01.01.2020)
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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease
Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
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The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
Savolainen, Mari H, Richie, Christopher T, Harvey, Brandon K, Männistö, Pekka T, Maguire-Zeiss, Kathleen A, Myöhänen, Timo T
Published in Neurobiology of disease (01.08.2014)
Published in Neurobiology of disease (01.08.2014)
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Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson’s disease in young and adult mouse
Savolainen, Mari H., Albert, Katrina, Airavaara, Mikko, Myöhänen, Timo T.
Published in Experimental brain research (01.07.2017)
Published in Experimental brain research (01.07.2017)
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Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Cui, Hengjing, Elford, Joshua D., Alitalo, Okko, Perez-Pardo, Paula, Tampio, Janne, Huttunen, Kristiina M., Kraneveld, Aletta, Forsberg, Markus M., Myöhänen, Timo T., Jalkanen, Aaro J.
Published in Neurobiology of aging (01.09.2023)
Published in Neurobiology of aging (01.09.2023)
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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model
Eteläinen, Tony S., Kilpeläinen, Tommi P., Ignatius, Adele, Auno, Samuli, De Lorenzo, Francesca, Uhari-Väänänen, Johanna K., Julku, Ulrika H., Myöhänen, Timo T.
Published in Neuropharmacology (01.11.2022)
Published in Neuropharmacology (01.11.2022)
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Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy
Cui, Hengjing, Kilpeläinen, Tommi, Zouzoula, Lydia, Auno, Samuli, Trontti, Kalevi, Kurvonen, Sampo, Norrbacka, Susanna, Hovatta, Iiris, Jensen, Poul Henning, Myöhänen, Timo T.
Published in Journal of cellular and molecular medicine (01.10.2021)
Published in Journal of cellular and molecular medicine (01.10.2021)
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The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
Kilpeläinen, Tommi P., Hellinen, Laura, Vrijdag, Johannes, Yan, Xu, Svarcbahs, Reinis, Vellonen, Kati-Sisko, Lambeir, Anne-Marie, Huttunen, Henri, Urtti, Arto, Wallen, Erik A.A, Myöhänen, Timo T.
Published in Biomedicine & pharmacotherapy (01.08.2020)
Published in Biomedicine & pharmacotherapy (01.08.2020)
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