Monoclonal antibodies targeting CD38 in hematological malignancies and beyond
van de Donk, Niels W. C. J., Janmaat, Maarten L., Mutis, Tuna, Lammerts van Bueren, Jeroen J., Ahmadi, Tahamtan, Sasser, A. Kate, Lokhorst, Henk M., Parren, Paul W. H. I.
Published in Immunological reviews (01.03.2016)
Published in Immunological reviews (01.03.2016)
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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide
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A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
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Published in Molecular therapy (02.08.2017)
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CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma
Nijhof, Inger S., Casneuf, Tineke, van Velzen, Jeroen, van Kessel, Berris, Axel, Amy E., Syed, Khaja, Groen, Richard W.J., van Duin, Mark, Sonneveld, Pieter, Minnema, Monique C., Zweegman, Sonja, Chiu, Christopher, Bloem, Andries C., Mutis, Tuna, Lokhorst, Henk M., Sasser, A.Kate, van de Donk, Niels W.C.J.
Published in Blood (18.08.2016)
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Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab
Casneuf, Tineke, Adams, Homer C., van de Donk, Niels W.C.J., Abraham, Yann, Bald, Jaime, Vanhoof, Greet, Van der Borght, Koen, Smets, Tina, Foulk, Brad, Nielsen, Karl C., Rusbuldt, Joshua, Axel, Amy, Lysaght, Andrew, Ceulemans, Hugo, Stevenaert, Frederik, Usmani, Saad Z., Plesner, Torben, Avet-Loiseau, Herve, Nijhof, Inger, Mutis, Tuna, Schecter, Jordan M., Chiu, Christopher, Bahlis, Nizar J.
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Published in Leukemia (01.02.2021)
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Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Krejcik, Jakub, Frerichs, Kris A, Nijhof, Inger S, van Kessel, Berris, van Velzen, Jeroen F, Bloem, Andries C, Broekmans, Marloes E C, Zweegman, Sonja, van Meerloo, Johan, Musters, René J P, Poddighe, Pino J, Groen, Richard W J, Chiu, Christopher, Plesner, Torben, Lokhorst, Henk M, Sasser, A Kate, Mutis, Tuna, van de Donk, Niels W C J
Published in Clinical cancer research (15.12.2017)
Published in Clinical cancer research (15.12.2017)
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Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma
Overdijk, Marije B, Verploegen, Sandra, Bögels, Marijn, van Egmond, Marjolein, van Bueren, Jeroen J Lammerts, Mutis, Tuna, Groen, Richard WJ, Breij, Esther, Martens, Anton CM, Bleeker, Wim K, Parren, Paul WHI
Published in mAbs (04.03.2015)
Published in mAbs (04.03.2015)
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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
de Weers, Michel, Tai, Yu-Tzu, van der Veer, Michael S, Bakker, Joost M, Vink, Tom, Jacobs, Daniëlle C H, Oomen, Lukas A, Peipp, Matthias, Valerius, Thomas, Slootstra, Jerry W, Mutis, Tuna, Bleeker, Wim K, Anderson, Kenneth C, Lokhorst, Henk M, van de Winkel, Jan G J, Parren, Paul W H I
Published in The Journal of immunology (1950) (01.02.2011)
Published in The Journal of immunology (1950) (01.02.2011)
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CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia
Naik, Jyoti, Themeli, Maria, de Jong-Korlaar, Regina, Ruiter, Ruud W J, Poddighe, Pino J, Yuan, Huipin, de Bruijn, Joost D, Ossenkoppele, Gert J, Zweegman, Sonja, Smit, Linda, Mutis, Tuna, Martens, Anton C M, van de Donk, Niels W C J, Groen, Richard W J
Published in Haematologica (Roma) (01.03.2019)
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Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment
van der Schans, Jort J., van de Donk, Niels W. C. J., Mutis, Tuna
Published in Frontiers in oncology (05.08.2020)
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Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
Nijhof, Inger S, Groen, Richard W J, Noort, Willy A, van Kessel, Berris, de Jong-Korlaar, Regina, Bakker, Joost, van Bueren, Jeroen J L, Parren, Paul W H I, Lokhorst, Henk M, van de Donk, Niels W C J, Martens, Anton C M, Mutis, Tuna
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design
Drent, Esther, Poels, Renée, Mulders, Manon J, van de Donk, Niels W C J, Themeli, Maria, Lokhorst, Henk M, Mutis, Tuna
Published in PloS one (30.05.2018)
Published in PloS one (30.05.2018)
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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
van Loosdregt, Jorg, Vercoulen, Yvonne, Guichelaar, Teun, Gent, Yoony Y.J., Beekman, Jeffrey M., van Beekum, Olivier, Brenkman, Arjan B., Hijnen, Dirk-Jan, Mutis, Tuna, Kalkhoven, Eric, Prakken, Berent J., Coffer, Paul J.
Published in Blood (04.02.2010)
Published in Blood (04.02.2010)
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Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma
Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna
Published in Haematologica (Roma) (01.05.2016)
Published in Haematologica (Roma) (01.05.2016)
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Preclinical Evaluation of Invariant Natural Killer T Cells Modified with CD38 or BCMA Chimeric Antigen Receptors for Multiple Myeloma
Poels, Renée, Drent, Esther, Lameris, Roeland, Katsarou, Afroditi, Themeli, Maria, van der Vliet, Hans J, de Gruijl, Tanja D, van de Donk, Niels W C J, Mutis, Tuna
Published in International journal of molecular sciences (22.01.2021)
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Targeted Therapy With Immunoconjugates for Multiple Myeloma
Bruins, Wassilis S C, Zweegman, Sonja, Mutis, Tuna, van de Donk, Niels W C J
Published in Frontiers in immunology (19.06.2020)
Published in Frontiers in immunology (19.06.2020)
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Preclinical Activity of JNJ-7957, a Novel BCMA×CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab
Frerichs, Kristine A, Broekmans, Marloes E C, Marin Soto, Jhon A, van Kessel, Berris, Heymans, Martijn W, Holthof, Lisa C, Verkleij, Christie P M, Boominathan, Rengasamy, Vaidya, Bhavesh, Sendecki, Jocelyn, Axel, Amy, Gaudet, Francois, Pillarisetti, Kodandaram, Zweegman, Sonja, Adams, 3rd, Homer C, Mutis, Tuna, van de Donk, Niels W C J
Published in Clinical cancer research (01.05.2020)
Published in Clinical cancer research (01.05.2020)
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The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction
Mutis, Tuna, Xagara, Anastasia, Spaapen, Robbert M
Published in Frontiers in immunology (24.06.2020)
Published in Frontiers in immunology (24.06.2020)
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Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients
Frerichs, Kristine A, Bosman, Patricia W C, van Velzen, Jeroen F, Fraaij, Pieter L A, Koopmans, Marion P G, Rimmelzwaan, Guus F, Nijhof, Inger S, Bloem, Andries C, Mutis, Tuna, Zweegman, Sonja, van de Donk, Niels W C J
Published in Haematologica (Roma) (01.06.2020)
Published in Haematologica (Roma) (01.06.2020)
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