The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat
Fryer, Ryan M, Muthukumarana, Akalushi, Harrison, Paul C, Nodop Mazurek, Suzanne, Chen, Rong Rhonda, Harrington, Kyle E, Dinallo, Roger M, Horan, Joshua C, Patnaude, Lori, Modis, Louise K, Reinhart, Glenn A
Published in PloS one (28.12.2012)
Published in PloS one (28.12.2012)
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CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells
Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L
Published in PloS one (29.08.2014)
Published in PloS one (29.08.2014)
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Physical Properties and Effect in a Battery of Safety Pharmacology Models for Three Structurally Distinct Enteric Polymers Employed as Spray-Dried Dispersion Carriers
Fryer, Ryan M, Patel, Mita, Zhang, Xiaomei, Baum-Kroker, Katja S, Muthukumarana, Akalushi, Linehan, Brian, Tseng, Yin-Chao
Published in Frontiers in pharmacology (13.10.2016)
Published in Frontiers in pharmacology (13.10.2016)
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Journal Article
Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors
Mazurek, Suzanne G. Nodop, Li, Jun, Nabozny, Gerald H., Reinhart, Glenn A., Muthukumarana, Akalushi C., Harrison, Paul C., Fryer, Ryan M.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Translation of in vitro adrenergic receptor binding in selectivity screen to in vivo functional cardiovascular effects during lead optimization
Chen, Rong Rhonda, Muthukumarana, Akalushi C., Boyer, Stephen J., Snow, Roger J., Reinhart, Glenn A., Harrison, Paul C., Fryer, Ryan M.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Effect of hemodynamically-active compounds across anesthetized and conscious cardiovascular models in rat and dog: Correlation with effects in humans
Muthukumarana, Akalushi C., Chen, Rhonda, Mazurek, Suzanne Nodop, Ng, Khing Jow, Reinhart, Glenn A., Harrison, Paul C., Fryer, Ryan M.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a K Ca 1.1 (BK Ca )–Dependent Mechanism
Fryer, Ryan M., Ng, Khing Jow, Nodop Mazurek, Suzanne G., Patnaude, Lori, Skow, Donna J., Muthukumarana, Akalushi, Gilpin, Kyle E., Dinallo, Roger M., Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A., Hickey, Eugene R., Modis, Louise K.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
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Journal Article
The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia
Fryer, Ryan M, Muthukumarana, Akalushi, Harrison, Paul C, Nodop Mazurek, Suzanne, Chen, Rong Rhonda, Harrington, Kyle E, Dinallo, Roger M, Horan, Joshua C, Patnaude, Lori, Modis, Louise K, Reinhart, Glenn A
Published in PloS one (28.12.2012)
Published in PloS one (28.12.2012)
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Journal Article
The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia in Rat
Fryer, Ryan M, Muthukumarana, Akalushi, Harrison, Paul C, Nodop Mazurek, Suzanne, Chen, Rong Rhonda, Harrington, Kyle E, Dinallo, Roger M, Horan, Joshua C, Patnaude, Lori, Modis, Louise K, Reinhart, Glenn A
Published in PloS one (28.12.2012)
Published in PloS one (28.12.2012)
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Journal Article
Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors
Fryer, Ryan M, Muthukumarana, Akalushi, Chen, Rong Rhonda, Smith, James D, Mazurek, Suzanne Nodop, Harrington, Kyle E, Dinallo, Roger M, Burke, Jennifer, DiCapua, Frank M, Guo, Xin, Kirrane, Thomas M, Snow, Roger J, Zhang, Yunlong, Soleymanzadeh, Fariba, Madwed, Jeffrey B, Kashem, Mohammed A, Kugler, Stanley Z, O'Neill, Margaret M, Harrison, Paul C, Reinhart, Glenn A, Boyer, Stephen J
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
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Journal Article
Strategic integration of in vivo cardiovascular models during lead optimization: predictive value of 4 models independent of species, route of administration, and influence of anesthesia
Fryer, Ryan M, Harrison, Paul C, Muthukumarana, Akalushi, Nodop Mazurek, Suzanne G, Ng, Khing Jow, Chen, Rong Rhonda, Harrington, Kyle E, Dinallo, Roger M, Chi, Liguo, Reinhart, Glenn A
Published in Journal of cardiovascular pharmacology (01.04.2012)
Published in Journal of cardiovascular pharmacology (01.04.2012)
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Journal Article
G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism
Fryer, Ryan M, Ng, Khing Jow, Nodop Mazurek, Suzanne G, Patnaude, Lori, Skow, Donna J, Muthukumarana, Akalushi, Gilpin, Kyle E, Dinallo, Roger M, Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A, Cerny, Matthew C, Hickey, Eugene R, Modis, Louise K
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
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Journal Article