Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis
McQuade, Jennifer L, Daniel, Carrie R, Hess, Kenneth R, Mak, Carmen, Wang, Daniel Y, Rai, Rajat R, Park, John J, Haydu, Lauren E, Spencer, Christine, Wongchenko, Matthew, Lane, Stephen, Lee, Dung-Yang, Kaper, Mathilde, McKean, Meredith, Beckermann, Kathryn E, Rubinstein, Samuel M, Rooney, Isabelle, Musib, Luna, Budha, Nageshwar, Hsu, Jessie, Nowicki, Theodore S, Avila, Alexandre, Haas, Tomas, Puligandla, Maneka, Lee, Sandra, Fang, Shenying, Wargo, Jennifer A, Gershenwald, Jeffrey E, Lee, Jeffrey E, Hwu, Patrick, Chapman, Paul B, Sosman, Jeffrey A, Schadendorf, Dirk, Grob, Jean-Jacques, Flaherty, Keith T, Walker, Dana, Yan, Yibing, McKenna, Edward, Legos, Jeffrey J, Carlino, Matteo S, Ribas, Antoni, Kirkwood, John M, Long, Georgina V, Johnson, Douglas B, Menzies, Alexander M, Davies, Michael A
Published in The lancet oncology (01.03.2018)
Published in The lancet oncology (01.03.2018)
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Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function
Sane, Rucha, Malhi, Vikram, Sutaria, Dhruvitkumar S, Cho, Eunpi, Twomey, Patrick, Craggs, Christopher, Wang, Jianshuang, Harris, Adam, Musib, Luna
Published in Journal of clinical pharmacology (01.02.2022)
Published in Journal of clinical pharmacology (01.02.2022)
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Journal Article
Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma
WICK, Wolfgang, PUDUVALLI, Vinay K, LIEPA, Astra M, THORNTON, Donald E, FINE, Howard A, CHAMBERLAIN, Marc C, VAN DEN BENT, Martin J, CARPENTIER, Antoine F, CHER, Lawrence M, MASON, Warren, WELLER, Michael, SHENGYAN HONG, MUSIB, Luna
Published in Journal of clinical oncology (01.03.2010)
Published in Journal of clinical oncology (01.03.2010)
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Journal Article
Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors
Shapiro, Geoffrey I., LoRusso, Patricia, Kwak, Eunice, Pandya, Susan, Rudin, Charles M., Kurkjian, Carla, Cleary, James M., Pilat, Mary Jo, Jones, Suzanne, de Crespigny, Alex, Fredrickson, Jill, Musib, Luna, Yan, Yibing, Wongchenko, Matthew, Hsieh, Hsin-Ju, Gates, Mary R., Chan, Iris T., Bendell, Johanna
Published in Investigational new drugs (01.04.2020)
Published in Investigational new drugs (01.04.2020)
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Journal Article
Assessment of cytochrome P450 3A4-mediated drug–drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model
Jing, Jing, Chen, Yuan, Musib, Luna, Jin, Jin Y., Cheung, Kit Wun Kathy, Yoshida, Kenta, Sane, Rucha
Published in Cancer chemotherapy and pharmacology (01.05.2022)
Published in Cancer chemotherapy and pharmacology (01.05.2022)
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Journal Article
Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects
Cheeti, Sravanthi, Hou, Hao Helen, Nelson, Eric, Walker, Helen, Chen, Buyun, Morley, Roland, Gates, Mary, Musib, Luna, Girish, Sandhya, Sahasranaman, Srikumar, Liu, Lichuan
Published in Pharmaceutical research (01.12.2018)
Published in Pharmaceutical research (01.12.2018)
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Journal Article
Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib
Malhi, Vikram, Budha, Nageshwar, Sane, Rucha, Huang, Jian, Liederer, Bianca, Meng, Raymond, Patel, Premal, Deng, Yuzhong, Cervantes, Andres, Tabernero, Josep, Musib, Luna
Published in Cancer chemotherapy and pharmacology (01.12.2021)
Published in Cancer chemotherapy and pharmacology (01.12.2021)
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Journal Article
Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation
Budha, Nageshwar R., Ji, Tao, Musib, Luna, Eppler, Steve, Dresser, Mark, Chen, Yuan, Jin, Jin Y.
Published in Clinical pharmacokinetics (01.11.2016)
Published in Clinical pharmacokinetics (01.11.2016)
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Journal Article
A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors
Shapiro, Geoffrey I., LoRusso, Patricia, Cho, Daniel C., Musib, Luna, Yan, Yibing, Wongchenko, Matthew, Chang, Ilsung, Patel, Premal, Chan, Iris T., Sanabria-Bohorquez, Sandra, Meng, Raymond D., Bendell, Johanna C.
Published in Investigational new drugs (01.02.2021)
Published in Investigational new drugs (01.02.2021)
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Journal Article
Correction to: Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects
Cheeti, Sravanthi, Hou, Hao Helen, Nelson, Eric, Walker, Helen, Chen, Buyun, Morley, Roland, Gates, Mary, Musib, Luna, Girish, Sandhya, Sahasranaman, Srikumar, Liu, Lichuan
Published in Pharmaceutical research (01.12.2018)
Published in Pharmaceutical research (01.12.2018)
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Journal Article
A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities
Lu, Dan, Lu, Tong, Stroh, Mark, Graham, Richard A., Agarwal, Priya, Musib, Luna, Li, Chi-Chung, Lum, Bert L., Joshi, Amita
Published in Cancer Chemotherapy and Pharmacology (01.03.2016)
Published in Cancer Chemotherapy and Pharmacology (01.03.2016)
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Journal Article
Book Review
Phase II Study of Enzastaurin, a Protein Kinase C Beta Inhibitor, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
ROBERTSON, Michael J, KAHL, Brad S, DARSTEIN, Christelle, ENAS, Nathan, KUTOK, Jeffery L, ASTER, Jon C, NEUBERG, Donna, SAVAGE, Kerry J, LACASCE, Ann, THORNTON, Donald, SLAPAK, Christopher A, SHIPP, Margaret A, VOSE, Julie M, DE VOS, Sven, LAUGHLIN, Mary, FLYNN, Patrick J, ROWLAND, Kendrith, CRUZ, José C, GOLDBERG, Stuart L, MUSIB, Luna
Published in Journal of clinical oncology (01.05.2007)
Published in Journal of clinical oncology (01.05.2007)
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Journal Article
Phase I Dose Escalation and Pharmacokinetic Study of Enzastaurin, an Oral Protein Kinase C Beta Inhibitor, in Patients With Advanced Cancer
CARDUCCI, Michael A, MUSIB, Luna, ENAS, Nathan, SINHA, Vikram, THORNTON, Donald E, HERBST, Roy S, KIES, Merrill S, PILI, Roberto, TRUONG, Mylene, BRAHMER, Julie R, COLE, Patricia, SULLIVAN, Rana, RIDDLE, Jeanne, SCHMIDT, Jill
Published in Journal of clinical oncology (01.09.2006)
Published in Journal of clinical oncology (01.09.2006)
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Journal Article
Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics
Cheeti, Sravanthi, Deng, Yuzhong, Chang, Ilsung, Georgescu, Isabela, Templeton, Ian, Choong, Nicholas, Cheung, Kit Wun Kathy, Girish, Sandhya, Musib, Luna
Published in Clinical pharmacology in drug development (01.02.2021)
Published in Clinical pharmacology in drug development (01.02.2021)
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Journal Article
Exposure–Response‐Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer
Zhu, Rui, Poland, Bill, Wada, Russ, Liu, Qi, Musib, Luna, Maslyar, Daniel, Cho, Eunpi, Yu, Wei, Ma, Han, Jin, Jin Yan, Budha, Nageshwar
Published in CPT: pharmacometrics and systems pharmacology (01.04.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.04.2019)
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Journal Article
Enzastaurin, an Oral Serine/Threonine Kinase Inhibitor, As Second- or Third-Line Therapy of Non–Small-Cell Lung Cancer
OH, Yun, HERBST, Roy S, BURRIS, Howard, CLEVERLY, Ann, MUSIB, Luna, LAHN, Michael, BEPLER, Gerold
Published in Journal of clinical oncology (01.03.2008)
Published in Journal of clinical oncology (01.03.2008)
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Journal Article
A Phase I Trial of Enzastaurin in Patients with Recurrent Gliomas
KREISL, Teri N, KIM, Lyndon, MOORE, Kraig, DUIC, Paul, KOTLIAROVA, Svetlana, WALLING, Jennifer, MUSIB, Luna, THORNTON, Donald, ALBERT, Paul S, FINE, Howard A
Published in Clinical cancer research (15.05.2009)
Published in Clinical cancer research (15.05.2009)
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Journal Article
Development and Validation of a Drug Activity Biomarker that Shows Target Inhibition in Cancer Patients Receiving Enzastaurin, a Novel Protein Kinase C-β Inhibitor
GREEN, Lisa J, MARDER, Philip, ECKHARDT, S. Gail, THORNTON, Donald, RAY, Chad, COOK, Carolyn A, JAKEN, Susan, MUSIB, Luna C, HERBST, Roy S, CARDUCCI, Michael, BRITTEN, Carolyn D, BASCHE, Michele
Published in Clinical cancer research (01.06.2006)
Published in Clinical cancer research (01.06.2006)
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Journal Article
Phase I and Pharmacokinetic Study of Pemetrexed plus Cisplatin in Chemonaive Patients with Locally Advanced or Metastatic Malignant Pleural Mesothelioma or Non–Small Cell Lung Cancer
Dickgreber, Nicolas J, Fink, Thomas H, Latz, Jane E, Hossain, Anwar M, Musib, Luna C, Thomas, Michael
Published in Clinical cancer research (01.01.2009)
Published in Clinical cancer research (01.01.2009)
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Journal Article
Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600 -mutated melanoma: a phase 1b study
Ribas, Antoni, Prof, Gonzalez, Rene, Prof, Pavlick, Anna, MD, Hamid, Omid, MD, Gajewski, Thomas F, Prof, Daud, Adil, Prof, Flaherty, Lawrence, MD, Logan, Theodore, MD, Chmielowski, Bartosz, MD, Lewis, Karl, MD, Kee, Damien, FRACP, Boasberg, Peter, MD, Yin, Ming, PhD, Chan, Iris, MD, Musib, Luna, PhD, Choong, Nicholas, MD, Puzanov, Igor, MD, McArthur, Grant A, Prof
Published in The lancet oncology (01.08.2014)
Published in The lancet oncology (01.08.2014)
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