Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
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Published in Clinical cancer research (15.02.2018)
Published in Clinical cancer research (15.02.2018)
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Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting
Karvonen, Hanna, Perttilä, Robert, Niininen, Wilhelmiina, Hautanen, Veera, Barker, Harlan, Murumägi, Astrid, Heckman, Caroline A., Ungureanu, Daniela
Published in Oncogene (01.04.2019)
Published in Oncogene (01.04.2019)
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Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms
Kangaspeska, Sara, Hultsch, Susanne, Edgren, Henrik, Nicorici, Daniel, Murumägi, Astrid, Kallioniemi, Olli
Published in PloS one (31.10.2012)
Published in PloS one (31.10.2012)
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KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia
Malani, Disha, Yadav, Bhagwan, Kumar, Ashwini, Potdar, Swapnil, Kontro, Mika, Kankainen, Matti, Javarappa, Komal K., Porkka, Kimmo, Wolf, Maija, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A., Murumägi, Astrid, Kallioniemi, Olli
Published in Leukemia (01.10.2020)
Published in Leukemia (01.10.2020)
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Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors
Jacome Sanz, Dafne, Raivola, Juuli, Karvonen, Hanna, Arjama, Mariliina, Barker, Harlan, Murumägi, Astrid, Ungureanu, Daniela
Published in Cancers (01.08.2021)
Published in Cancers (01.08.2021)
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Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
Pemovska, Tea, Kontro, Mika, Yadav, Bhagwan, Edgren, Henrik, Eldfors, Samuli, Szwajda, Agnieszka, Almusa, Henrikki, Bespalov, Maxim M, Ellonen, Pekka, Elonen, Erkki, Gjertsen, Bjørn T, Karjalainen, Riikka, Kulesskiy, Evgeny, Lagström, Sonja, Lehto, Anna, Lepistö, Maija, Lundán, Tuija, Majumder, Muntasir Mamun, Marti, Jesus M Lopez, Mattila, Pirkko, Murumägi, Astrid, Mustjoki, Satu, Palva, Aino, Parsons, Alun, Pirttinen, Tero, Rämet, Maria E, Suvela, Minna, Turunen, Laura, Västrik, Imre, Wolf, Maija, Knowles, Jonathan, Aittokallio, Tero, Heckman, Caroline A, Porkka, Kimmo, Kallioniemi, Olli, Wennerberg, Krister
Published in Cancer discovery (01.12.2013)
Published in Cancer discovery (01.12.2013)
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Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention
Raivola, Juuli, Dini, Alice, Karvonen, Hanna, Piki, Emilia, Salokas, Kari, Niininen, Wilhelmiina, Kaleva, Laura, Zhang, Kaiyang, Arjama, Mariliina, Gudoityte, Greta, Seashore-Ludlow, Brinton, Varjosalo, Markku, Kallioniemi, Olli, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela
Published in Cell death & disease (17.08.2022)
Published in Cell death & disease (17.08.2022)
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Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma
Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli
Published in British journal of cancer (16.02.2023)
Published in British journal of cancer (16.02.2023)
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Anagrelide for Gastrointestinal Stromal Tumor
Pulkka, Olli-Pekka, Gebreyohannes, Yemarshet K, Wozniak, Agnieszka, Mpindi, John-Patrick, Tynninen, Olli, Icay, Katherine, Cervera, Alejandra, Keskitalo, Salla, Murumägi, Astrid, Kulesskiy, Evgeny, Laaksonen, Maria, Wennerberg, Krister, Varjosalo, Markku, Laakkonen, Pirjo, Lehtonen, Rainer, Hautaniemi, Sampsa, Kallioniemi, Olli, Schöffski, Patrick, Sihto, Harri, Joensuu, Heikki
Published in Clinical cancer research (01.03.2019)
Published in Clinical cancer research (01.03.2019)
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Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes
Kisand, Kai, Link, Maire, Wolff, Anette S.B., Meager, Anthony, Tserel, Liina, Org, Tõnis, Murumägi, Astrid, Uibo, Raivo, Willcox, Nick, Trebušak Podkrajšek, Katarina, Battelino, Tadej, Lobell, Anna, Kämpe, Olle, Lima, Kari, Meloni, Antonella, Ergun-Longmire, Berrin, Maclaren, Noel K., Perheentupa, Jaakko, Krohn, Kai J.E., Scott, Hamish S., Husebye, Eystein S., Peterson, Pärt
Published in Blood (01.10.2008)
Published in Blood (01.10.2008)
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Ets transcription factors regulate AIRE gene promoter
Murumägi, Astrid, Silvennoinen, Olli, Peterson, Pärt
Published in Biochemical and biophysical research communications (22.09.2006)
Published in Biochemical and biophysical research communications (22.09.2006)
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Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
Yadav, Bhagwan, Pemovska, Tea, Szwajda, Agnieszka, Kulesskiy, Evgeny, Kontro, Mika, Karjalainen, Riikka, Majumder, Muntasir Mamun, Malani, Disha, Murumägi, Astrid, Knowles, Jonathan, Porkka, Kimmo, Heckman, Caroline, Kallioniemi, Olli, Wennerberg, Krister, Aittokallio, Tero
Published in Scientific reports (05.06.2014)
Published in Scientific reports (05.06.2014)
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Targeting ROR1 identifies new treatment strategies in hematological cancers
Karvonen, Hanna, Niininen, Wilhelmiina, Murumägi, Astrid, Ungureanu, Daniela
Published in Biochemical Society transactions (15.04.2017)
Published in Biochemical Society transactions (15.04.2017)
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High-Throughput Ex Vivo Drug Sensitivity and Resistance Testing (DSRT) Integrated with Deep Genomic and Molecular Profiling Reveal New Therapy Options with Targeted Drugs in Subgroups of Relapsed Chemorefractory AML
Heckman, Caroline A, Kontro, Mika, Pemovska, Tea, Eldfors, Samuli, Edgren, Henrik, Kulesskiy, Evgeny, Majumder, Muntasir Mamun, Karjalainen, Riikka, Yadav, Bhagwan, Szwajda, Agnieszka, Venkata, Naga Poojitha Kota, Murumägi, Astrid, Malani, Disha, Parsons, Alun, Hintsanen, Petteri, Almusa, Henrikki, Martí, Jesús María López, Ellonen, Pekka, Mattila, Pirkko, Lepistö, Maija, Lagström, Sonja, Suvela, Minna, Mustjoki, Satu, Saarela, Janna, Aittokallio, Tero, Kallioniemi, Olli, Wennerberg, Krister, Porkka, Kimmo
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Development of a Cancer Pharmacopeia-Wide Ex-Vivo Drug Sensitivity and Resistance Testing (DSRT) Platform: Identification of MEK and mTOR As Patient-Specific Molecular Drivers of Adult AML and Potent Therapeutic Combinations with Dasatinib
Kontro, Mika, Heckman, Caroline, Kulesskiy, Evgeny, Pemovska, Tea, Bespalov, Maxim, Eldfors, Samuli, Erkki, Elonen, Karjalainen, Riikka, Knowles, Jonathan, Malani, Disha, Majumder, Muntasir Mamun, Mpindi, John Patrick, Murumägi, Astrid, Mustjoki, Satu, Turunen, Laura, Wolf, Maija, Porkka, Kimmo, Wennerberg, Krister, Kallioniemi, Olli
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization
Ammad-Ud-Din, Muhammad, Khan, Suleiman A, Malani, Disha, Murumägi, Astrid, Kallioniemi, Olli, Aittokallio, Tero, Kaski, Samuel
Published in Bioinformatics (Oxford, England) (01.09.2016)
Published in Bioinformatics (Oxford, England) (01.09.2016)
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Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness
Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela
Published in Cell death & disease (23.09.2020)
Published in Cell death & disease (23.09.2020)
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Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1
Meager, Anthony, Visvalingam, Kumuthini, Peterson, Pärt, Möll, Kaidi, Murumägi, Astrid, Krohn, Kai, Eskelin, Petra, Perheentupa, Jaakko, Husebye, Eystein, Kadota, Yoshihisa, Willcox, Nick
Published in PLoS medicine (01.07.2006)
Published in PLoS medicine (01.07.2006)
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Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma
Karvonen, Hanna, Chiron, David, Niininen, Wilhelmiina, Ek, Sara, Jerkeman, Mats, Moradi, Elaheh, Nykter, Matti, Heckman, Caroline A., Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela
Published in Blood (14.11.2017)
Published in Blood (14.11.2017)
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