Critical role of kinase activity of hematopoietic progenitor kinase 1 in anti-tumor immune surveillance
Liu, Jinqi, Curtin, Joshua, You, Dan, Hillerman, Stephen, Li-Wang, Bifang, Eraslan, Rukiye, Xie, Jenny, Swanson, Jesse, Ho, Ching-Ping, Oppenheimer, Simone, Warrack, Bethanne M, McNaney, Colleen A, Nelson, David M, Blum, Jordan, Kim, Taeg, Fereshteh, Mark, Reily, Michael, Shipkova, Petia, Murtaza, Anwar, Sanjuan, Miguel, Hunt, John T, Salter-Cid, Luisa
Published in PloS one (26.03.2019)
Published in PloS one (26.03.2019)
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Journal Article
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Wu, Chengbin, Ying, Hua, Grinnell, Christine, Bryant, Shaughn, Miller, Renee, Clabbers, Anca, Bose, Sahana, McCarthy, Donna, Zhu, Rong-Rong, Santora, Ling, Davis-Taber, Rachel, Kunes, Yune, Fung, Emma, Schwartz, Annette, Sakorafas, Paul, Gu, Jijie, Tarcsa, Edit, Murtaza, Anwar, Ghayur, Tariq
Published in Nature biotechnology (01.11.2007)
Published in Nature biotechnology (01.11.2007)
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Journal Article
Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor
You, Dan, Hillerman, Stephen, Locke, Gregory, Chaudhry, Charu, Stromko, Caitlyn, Murtaza, Anwar, Fan, Yi, Koenitzer, Jennifer, Chen, Yali, Briceno, Stephanie, Bhadra, Rajarshi, Duperret, Elizabeth, Gullo-Brown, Johnni, Gao, Chan, Zhao, Dandan, Feder, John, Curtin, Joshua, Degnan, Andrew P, Kumi, Godwin, Wittman, Mark, Johnson, Benjamin M, Parrish, Karen E, Gokulrangan, Giridharan, Morrison, John, Quigley, Michael, Hunt, John T, Salter-Cid, Luisa, Lees, Emma, Sanjuan, Miguel A, Liu, Jinqi
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Journal Article
Pharmacodynamics‐based approach for efficacious human dose projection of BMS‐986260, a small molecule transforming growth factor beta receptor 1 inhibitor
Parrish, Karen E., Swanson, Jesse, Cheng, Lihong, Luk, Emily, Stetsko, Paul, Smalley, James, Shu, Yue‐Zhong, Huang, Jinwen, Pabalan, Jonathan G., Sun, Yongnian, Zvyaga, Tatyana, Cvijic, Mary Ellen, Burke, James, Borzilleri, Robert, Murtaza, Anwar, Augustine, Karen, Yang, Zheng
Published in Biopharmaceutics & drug disposition (01.04.2021)
Published in Biopharmaceutics & drug disposition (01.04.2021)
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Journal Article
A T Cell Receptor Antagonist Peptide Induces T Cells that Mediate Bystander Suppression and Prevent Autoimmune Encephalomyelitis Induced with Multiple Myelin Antigens
Nicholson, Lindsay B., Murtaza, Anwar, Hafler, Brian P., Sette, Alessandro, Kuchroo, Vijay K.
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.1997)
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Journal Article
Cell-Type and Stimulus Determine the Impact of the Serine/Threonine Kinase Cot/Tpl2 in Acute and Chronic Inflammation
Murtaza, Anwar, Senior Scientist, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Bryant, Shaughn, Research Associate, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Mathieu, Suzanne, Research Associate, Abbott Bioresearch Center, Pharmacology, Worcester, MA, Allen, Hamish, Director, Abbott Bioresearch Center, Molecular and Cellular Biology, Worcester, MA, Tripp, Catherine, Senior Director, Abbott Bioresearch Center, Worcester, MA, Wishart, Neil, Associate Director, Abbott Bioresearch Center, Chemistry, Worcester, MA
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
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Journal Article
Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL)
Gallego, Rebecca A., Scales, Stephanie, Toledo, Chad, Auth, Marin, Bernier, Louise, Berry, Madeline, Brun, Sonja, Chung, Loanne, Davis, Carl, Diehl, Wade, Dress, Klaus, Eisele, Koleen, Elleraas, Jeff, Ewanicki, Jason, Fobian, Yvette, Greasley, Samantha, Greenwald, Eric C., Johnson, Ted W., Khamphavong, Penney, Lafontaine, Jennifer, Li, Jian, Linton, Angelica, Maestre, Michael, Miller, Nichol, Murtaza, Anwar, Patman, Ryan L., Quinlan, Casey L., Ramms, Dana J., Richardson, Paul, Sach, Neal, Salomon-Ferrer, Romelia, Silva, Francisco, Timofeevski, Sergei, Tran, Phuong, Tran-Dubé, Michelle, Wang, Fen, Wang, Wei, Wythes, Martin, Yang, Shouliang, Zou, Aihua, VanArsdale, Todd, McAlpine, Indrawan
Published in Journal of medicinal chemistry (14.11.2024)
Published in Journal of medicinal chemistry (14.11.2024)
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Journal Article
Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor
Zhang, Yong, Parrish, Karen E, Tortolani, David R, Poss, Michael A, Huang, Audris, Wan, Honghe, Purandare, Ashok V, Donnell, Andrew F, Kempson, James, Hou, Xiaoping, Pawluczyk, Joseph, Yip, Shiuhang, Luk, Emily, Raghavan, Nimmi, Swanson, Jesse, Smalley, James, Murtaza, Anwar, Yang, Zheng, Augustine-Rauch, Karen, Lombardo, Louis J, Borzilleri, Robert
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Abstract 5709: PF-07104091, a first-in-class CDK2-selective inhibitor for the treatment of HR+/HER2- breast cancer and CCNE1high ovarian cancer
Shen, Chen, Qiu, Ming, Huser, Nanni, Pascual, Bernadette, Zhang, Qin, VanArsdale, Todd, Murtaza, Anwar, Almaden, Jonathan, Kim, berly, Anders, Lars, Eisele, Koleen
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1
Degnan, Andrew P, Kumi, Godwin K, Allard, Christopher W, Araujo, Erika V, Johnson, Walter L, Zimmermann, Kurt, Pearce, Bradley C, Sheriff, Steven, Futran, Alan, Li, Xin, Locke, Gregory A, You, Dan, Morrison, John, Parrish, Karen E, Stromko, Caitlyn, Murtaza, Anwar, Liu, Jinqi, Johnson, Benjamin M, Vite, Gregory D, Wittman, Mark D
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists
Harikrishnan, Lalgudi S., Gill, Patrice, Kamau, Muthoni G., Qin, Lan-Ying, Ruan, Zheming, O'Malley, Daniel, Huynh, Tram, Stachura, Sylwia, Cavallaro, Cullen L., Lu, Zhonghui, J.-W. Duan, James, Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Murtaza, Anwar, Fink, Brian E.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
Published in Bioorganic & medicinal chemistry letters (15.06.2020)
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Journal Article
Abstract 3760: Preclinical antitumor activity of a CC chemokine receptor (CCR) 2/5 dual antagonist as monotherapy and in combination with immune checkpoint blockade
Zhao, Qihong, Murtaza, Anwar, Bata, Adam, Sun, Wendy, Ho, Ching-Ping, Vuppugalla, Ragini, Cherney, Robert, Stefanski, Kevin, Cao, Z Alexander, Sama, Ashwin, Yang, Arvin, Struthers, Mary, Sanjuan, Miguel, Hunt, John T., Carter, Percy, Salter-Cid, Luisa
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology
Poudel, Yam B., He, Liqi, Cox, Matthew, Zhang, Qian, Johnson, Walter L., Cong, Qiang, Cheng, Heng, Chowdari, Naidu S., Tarby, Christine, Donnell, Andrew F., Broekema, Matthais, O’Malley, Daniel P., Zhang, Yong, A. M. Subbaiah, Murugaiah, Kumar, Boda Vijay, Subramani, Lakshumanan, Wang, Bei, Li, Yi-Xin, Sivaprakasam, Prasanna, Critton, David, Mulligan, Dawn, Sandhu, Bhupindar, Xie, Chunshan, Ramakrishnan, Radha, Nagar, Jignesh, Dudhgaonkar, Shailesh, Oderinde, Martins S., Murtaza, Anwar, Schieven, Gary L., Mathur, Arvind, Gavai, Ashvinikumar V., Vite, Gregory, Gangwar, Sanjeev
Published in ACS medicinal chemistry letters (08.02.2024)
Published in ACS medicinal chemistry letters (08.02.2024)
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Journal Article
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology
He, Liqi, Zhang, Meng Yao, Cox, Matthew, Zhang, Qian, Donnell, Andrew F., Zhang, Yong, Tarby, Christine, Gill, Patrice, Subbaiah, Murugaiah A. M., Ramar, Thangeswaran, Reddy, Maheswara, Puttapaka, Vijaya, Li, Yi-Xin, Sivaprakasam, Prasanna, Critton, David, Mulligan, Dawn, Xie, Chunshan, Ramakrishnan, Radha, Nagar, Jignesh, Dudhgaonkar, Shailesh, Murtaza, Anwar, Oderinde, Martins S., Schieven, Gary L., Mathur, Arvind, Gavai, Ashvinikumar V., Vite, Gregory, Gangwar, Sanjeev, Poudel, Yam B.
Published in ACS medicinal chemistry letters (08.02.2024)
Published in ACS medicinal chemistry letters (08.02.2024)
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Journal Article
Abstract 595: Preclinical development of the CDK4 selective inhibitor PF-07220060: Increased CDK4 versus CDK6 inhibition leads to improved anti-tumor efficacy at therapeutic concentrations
Anders, Lars, Pascual, Bernadette, Boras, Britton, Cianfrogna, Julie, Garza, Scott, Li, Na, Yuan, Jing Tang, Moen, Mark, Huser, Nanni, Gallego, Gary, Jalaie, Mehran, Ninkovic, Sacha, Cho-Schultz, Sujin, Shen, Hong, Kath, John, Dress, Klaus, Diehl, Wade, Nair, Sajiv, Jones, Rhys, Lafontaine, Jennifer, Murtaza, Anwar, Sacaan, Aida, Chintharlapalli, Sudhakar, VanArsdale, Todd
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent
Velaparthi, Upender, Darne, Chetan Padmakar, Warrier, Jayakumar, Liu, Peiying, Rahaman, Hasibur, Augustine-Rauch, Karen, Parrish, Karen, Yang, Zheng, Swanson, Jesse, Brown, Jennifer, Dhar, Gopal, Anandam, Aravind, Holenarsipur, Vinay K, Palanisamy, Kamalavenkatesh, Wautlet, Barri S, Fereshteh, Mark P, Lippy, Jonathan, Tebben, Andrew J, Sheriff, Steven, Ruzanov, Max, Yan, Chunhong, Gupta, Anuradha, Gupta, Arun Kumar, Vetrichelvan, Muthalagu, Mathur, Arvind, Gelman, Marina, Singh, Rajinder, Kinsella, Todd, Murtaza, Anwar, Fargnoli, Joseph, Vite, Gregory, Borzilleri, Robert M
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
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Journal Article
Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors
Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
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Abstract 5903: MASTL small-molecule inhibition to target mitosis for cancer therapy
Toledo, Chad M., Eisele, Koleen J., Kim, Dong Hyun, Mu, Xinmeng, Brun, Sonja, Davis, Carl, Greenwald, Eric C., Hui, Fion, He, Meilan, Yang, Yanling, Flores-Bojorquez, Ana, Li, Yuxin, Khamphavong, Penney L., Lee, Joseph H., Li, Jian, Ramms, Dana J., Jones, Greg, Auth, Marin, Painter, Cory L., Nager, Andrew, Oyer, Jon, Timofeevski, Sergei L., Pierceall, William E., Murtaza, Anwar, Heyen, Jonathan R., Gallego, Rebecca, Quinlan, Casey, McAlpine, Indrawan, VanArsdale, Todd L.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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