Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys
Yamada, Makiko, Takei, Makoto, Suzuki, Eiko, Takakusa, Hideo, Kotsuma, Masakatsu, Washio, Takuo, Murayama, Nobuyuki, Inoue, Shin-ichi, Izumi, Takashi
Published in Xenobiotica (02.12.2017)
Published in Xenobiotica (02.12.2017)
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Prediction of Human Pharmacokinetics of Therapeutic Monoclonal Antibodies from Simple Allometry of Monkey Data
Oitate, Masataka, Masubuchi, Noriko, Ito, Takashi, Yabe, Yoshiyuki, Karibe, Tsuyoshi, Aoki, Takanori, Murayama, Nobuyuki, Kurihara, Atsushi, Okudaira, Noriko, Izumi, Takashi
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
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Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1
Ishizuka, Tomoko, Yoshigae, Yasushi, Murayama, Nobuyuki, Izumi, Takashi
Published in Drug metabolism and disposition (01.11.2013)
Published in Drug metabolism and disposition (01.11.2013)
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6 β -Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/ SLC22A8 , in Healthy Subjects
Imamura, Yuichiro, Tsuruya, Yuri, Damme, Katja, Heer, Dominik, Kumagai, Yuji, Maeda, Kazuya, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Izumi, Takashi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects
Imamura, Yuichiro, Tsuruya, Yuri, Damme, Katja, Heer, Dominik, Kumagai, Yuji, Maeda, Kazuya, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Izumi, Takashi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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Effect of the Fluoroquinolone Antibacterial Agent DX-619 on the Apparent Formation and Renal Clearances of 6β-Hydroxycortisol, an Endogenous Probe for CYP3A4 Inhibition, in Healthy Subjects
Imamura, Yuichiro, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Inoue, Katsuhisa, Yuasa, Hiroaki, Izumi, Takashi, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in Pharmaceutical research (01.02.2013)
Published in Pharmaceutical research (01.02.2013)
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Prediction of in Vivo Potential for Metabolic Activation of Drugs into Chemically Reactive Intermediate: Correlation of in Vitro and in Vivo Generation of Reactive Intermediates and in Vitro Glutathione Conjugate Formation in Rats and Humans
Masubuchi, Noriko, Makino, Chie, Murayama, Nobuyuki
Published in Chemical research in toxicology (01.03.2007)
Published in Chemical research in toxicology (01.03.2007)
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Radioimmunoassay method for DX-9065a, an anticoagulant agent. Development, evaluation and application to human plasma
Murayama, Nobuyuki, Tanaka, Shuko, Kikuchi, Takae, Nakaoka, Minoru, Sudo, Ken-ichi
Published in Journal of pharmaceutical and biomedical analysis (01.08.1996)
Published in Journal of pharmaceutical and biomedical analysis (01.08.1996)
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Effect of the Fluoroquinolone Antibacterial Agent DX-619 on the Apparent Formation and Renal Clearances of 6[beta]-Hydroxycortisol, an Endogenous Probe for CYP3A4 Inhibition, in Healthy Subjects
Imamura, Yuichiro, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Inoue, Katsuhisa, Yuasa, Hiroaki, Izumi, Takashi, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in Pharmaceutical research (01.02.2013)
Published in Pharmaceutical research (01.02.2013)
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Contribution of lysosomes to concentrative uptake of DX-9065a into rat liver
Murayama, Nobuyuki, Nakaoka, Minoru, Sudo, Kenichi
Published in Journal of pharmaceutical sciences (01.08.2006)
Published in Journal of pharmaceutical sciences (01.08.2006)
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Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers
Murayama, N, Tanaka, M, Kunitada, S, Yamada, H, Inoue, T, Terada, Y, Fujita, M, Ikeda, Y
Published in Clinical pharmacology and therapeutics (01.09.1999)
Published in Clinical pharmacology and therapeutics (01.09.1999)
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