Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Halvard Grønlien, Jens, Håkerud, Monika, Ween, Hilde, Thorin-Hagene, Kirsten, Briggs, Clark A., Gopalakrishnan, Murali, Malysz, John
Published in Molecular pharmacology (01.09.2007)
Published in Molecular pharmacology (01.09.2007)
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An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
Timmermann, Daniel B., Grønlien, Jens Halvard, Kohlhaas, Kathy L., Nielsen, Elsebet Ø., Dam, Eva, Jørgensen, Tino D., Ahring, Philip K., Peters, Dan, Holst, Dorte, Chrsitensen, Jeppe K., Malysz, John, Briggs, Clark A., Gopalakrishnan, Murali, Olsen, Gunnar M.
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats
Zhu, Chang Z., Doyle, Kelly J., Nikkel, Arthur L., Olsen, Lauren, Namovic, Marian T., Salte, Katherine, Widomski, Deborah, Su, Zhi, Donnelly-Roberts, Diana L., Gopalakrishnan, Murali M., McGaraughty, Steve
Published in Journal of pharmacological and toxicological methods (01.11.2018)
Published in Journal of pharmacological and toxicological methods (01.11.2018)
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Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities
Shieh, C C, Coghlan, M, Sullivan, J P, Gopalakrishnan, M
Published in Pharmacological reviews (01.12.2000)
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Published in Pharmacological reviews (01.12.2000)
Journal Article
High content screen microscopy analysis of Aβ1–42 -induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of α7 neuronal nicotinic acetylcholine receptor ligands
Hu, Min, Schurdak, Mark E, Puttfarcken, Pamela S, El Kouhen, Rachid, Gopalakrishnan, Murali, Li, Jinhe
Published in Brain research (04.09.2007)
Published in Brain research (04.09.2007)
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Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Antisense knockdown of the rat α7 nicotinic acetylcholine receptor produces spatial memory impairment
Curzon, Peter, Anderson, David J., Nikkel, Arthur L., Fox, Gerard B., Gopalakrishnan, Murali, Decker, Michael W., Bitner, Robert S.
Published in Neuroscience letters (01.12.2006)
Published in Neuroscience letters (01.12.2006)
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Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators
Buckner, Steven A, Milicic, Ivan, Daza, Anthony V, Coghlan, Michael J, Gopalakrishnan, Murali
Published in British journal of pharmacology (01.02.2002)
Published in British journal of pharmacology (01.02.2002)
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Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk − cells
Malysz, John, Scott, Victoria E., Faltynek, Connie, Gopalakrishnan, Murali
Published in Life sciences (1973) (02.01.2008)
Published in Life sciences (1973) (02.01.2008)
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Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener
Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A
Published in Journal of medicinal chemistry (16.11.2006)
Published in Journal of medicinal chemistry (16.11.2006)
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Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury
Zhang, Xu-Feng, Zhu, Chang Z, Thimmapaya, Rama, Choi, Won S, Honore, Prisca, Scott, Victoria E, Kroeger, Paul E, Sullivan, James P, Faltynek, Connie R, Gopalakrishnan, Murali, Shieh, Char-Chang
Published in Brain research (29.05.2004)
Published in Brain research (29.05.2004)
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Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle
Malysz, John, Buckner, Steven A, Daza, Anthony V, Milicic, Ivan, Perez-Medrano, Arturo, Gopalakrishnan, Murali
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.05.2004)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.05.2004)
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Journal Article
Association of Catsper1 or -2 with Cav3.3 Leads to Suppression of T-type Calcium Channel Activity
Zhang, Di, Chen, Jun, Saraf, Anita, Cassar, Steven, Han, Ping, Rogers, John C., Brioni, Jorge D., Sullivan, James P., Gopalakrishnan, Murali
Published in The Journal of biological chemistry (04.08.2006)
Published in The Journal of biological chemistry (04.08.2006)
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Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists
Chen, Jun, Lake, Marc R, Sabet, Reza S, Niforatos, Wende, Pratt, Steve D, Cassar, Steven C, Xu, Jing, Gopalakrishnan, Sujatha, Pereda-Lopez, Ana, Gopalakrishnan, Murali, Holzman, Thomas F, Moreland, Robert B, Walter, Karl A, Faltynek, Connie R, Warrior, Usha, Scott, Victoria E
Published in Journal of biomolecular screening (01.02.2007)
Published in Journal of biomolecular screening (01.02.2007)
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