PHARMACODYNAMICS AND PHARMACOKINETICS OF THE POTASSIUM-COMPETITIVE ACID BLOCKER VONOPRAZAN AND THE PROTON PUMP INHIBITOR LANSOPRAZOLE IN U.S. SUBJECTS
Laine, Loren, Sharma, Prateek, Mulford, Darcy J, Hunt, Barbara, Leifke, Eckhard, Smith, Neila, Howden, Colin W
Published in The American journal of gastroenterology (01.07.2022)
Published in The American journal of gastroenterology (01.07.2022)
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Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms ( CYP2C19 , ABCB1 , PON1 ), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function
Frelinger, Andrew L., PhD, Bhatt, Deepak L., MD, MPH, Lee, Ronald D., PhD, Mulford, Darcy J., PhD, Wu, Jingtao, PhD, Nudurupati, Sai, PhD, Nigam, Anu, MS, Lampa, Michael, BS, Brooks, Julie K., MS, Barnard, Marc R., MS, Michelson, Alan D., MD
Published in Journal of the American College of Cardiology (26.02.2013)
Published in Journal of the American College of Cardiology (26.02.2013)
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A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers
Frelinger, Andrew L., PhD, Lee, Ronald D., PhD, Mulford, Darcy J., PhD, Wu, Jingtao, PhD, Nudurupati, Sai, PhD, Nigam, Anu, MS, Brooks, Julie K., MS, Bhatt, Deepak L., MD, MPH, Michelson, Alan D., MD
Published in Journal of the American College of Cardiology (03.04.2012)
Published in Journal of the American College of Cardiology (03.04.2012)
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A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
Scarpignato, Carmelo, Leifke, Eckhard, Smith, Neila, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Howden, Colin W.
Published in Journal of clinical pharmacology (01.06.2022)
Published in Journal of clinical pharmacology (01.06.2022)
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A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection
Scarpignato, Carmelo, Howden, Colin W., Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Hunt, Richard
Published in Alimentary pharmacology & therapeutics (01.07.2023)
Published in Alimentary pharmacology & therapeutics (01.07.2023)
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Response to Graham
Laine, Loren, Sharma, Prateek, Mulford, Darcy J., Hunt, Barbara, Leifke, Eckhard, Smith, Neila, Howden, Colin W.
Published in The American journal of gastroenterology (01.11.2022)
Published in The American journal of gastroenterology (01.11.2022)
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S470 Development and Utilization of a Pharmacokinetic/Pharmacodynamic Model for Vonoprazan to Assess the Relationship Between Dose, Exposure, and pH Holding Time Ratio
Scarpignato, Carmelo, Howden, Colin W., Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Hunt, Richard
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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S1387 A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race and Disease Status on Exposure
Scarpignato, Carmelo, Leifke, Eckhard, Smith, Neila, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Howden, Colin W.
Published in The American journal of gastroenterology (01.10.2021)
Published in The American journal of gastroenterology (01.10.2021)
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Mathematical model of the relationship between pH holding time and erosive esophagitis healing rates
Howden, Colin W., Scarpignato, Carmelo, Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Yuan, Yuhong, Hunt, Richard
Published in CPT: pharmacometrics and systems pharmacology (19.09.2024)
Published in CPT: pharmacometrics and systems pharmacology (19.09.2024)
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Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling
Mulford, Darcy J., Ramsden, Diane, Zhang, Liming, Michon, Ingrid, Leifke, Eckhard, Smith, Neila, Jones, Hannah M., Scarpignato, Carmelo
Published in CPT: pharmacometrics and systems pharmacology (01.04.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.04.2023)
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Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment
Mayer, Michael D, Khosravan, Reza, Vernillet, Laurent, Wu, Jing-Tao, Joseph-Ridge, Nancy, Mulford, Darcy J
Published in American journal of therapeutics (01.01.2005)
Published in American journal of therapeutics (01.01.2005)
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CLOPIDOGREL PHARMACOKINETICS AND PHARMACODYNAMICS VARY WIDELY, INDEPENDENT OF CYP2C19 POLYMORPHISMS, DIET, SMOKING, PROTON PUMP INHIBITORS AND OTHER CO-MEDICATIONS
Frelinger, Andrew L, Bhatt, Deepak L, Lee, Ronald D, Mulford, Darcy J, Wu, Jingtao, Michelson, Alan D
Published in Journal of the American College of Cardiology (05.04.2011)
Published in Journal of the American College of Cardiology (05.04.2011)
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A RANDOMIZED OPEN-LABEL 2-PERIOD CROSSOVER DESIGN STUDY TO ASSESS THE STEADY-STATE EFFECTS OF DEXLANSOPRAZOLE LANSOPRAZOLE ESOMEPRAZOLE OR OMEPRAZOLE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF CLOPIDOGREL IN HEALTHY SUBJECTS
Frelinger, Andrew L, Lee, Ronald D, Mulford, Darcy J, Wu, Jingtao, Bhatt, Deepak L, Michelson, Alan D
Published in Journal of the American College of Cardiology (05.04.2011)
Published in Journal of the American College of Cardiology (05.04.2011)
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Tu1296 A MODEL-BASED META-ANALYSIS OF THE RELATIONSHIP BETWEEN PH CONTROL AND EROSIVE ESOPHAGITIS HEALING RATES
Howden, Colin W., Scarpignato, Carmelo, Leifke, Eckhard, Mulford, Darcy J., Lahu, Gezim, Facius, Axel, Yuan, Yuhong, Hunt, Richard H.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
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