Inducing and exploiting vulnerabilities for the treatment of liver cancer
Wang, Cun, Vegna, Serena, Jin, Haojie, Benedict, Bente, Lieftink, Cor, Ramirez, Christel, de Oliveira, Rodrigo Leite, Morris, Ben, Gadiot, Jules, Wang, Wei, du Chatinier, Aimée, Wang, Liqin, Gao, Dongmei, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Schepers, Arnout, Jochems, Fleur, Sanchez, Antonio Mulero, Mainardi, Sara, te Riele, Hein, Beijersbergen, Roderick L., Qin, Wenxin, Akkari, Leila, Bernards, René
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma
Mulero‐Sánchez, Antonio, Ramirez, Christel F. A., Chatinier, Aimée, Wang, Hui, Koomen, Sofie J. I., Song, Ji‐Ying, Groot, Marnix H. P., Lieftink, Cor, Bosma, Astrid, Burylo, Artur, Tellingen, Olaf, Beijersbergen, Roderick L., Wang, Cun, Akkari, Leila, Bernards, René, Mainardi, Sara
Published in Molecular oncology (01.06.2023)
Published in Molecular oncology (01.06.2023)
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Journal Article
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo
Mainardi, Sara, Mulero-Sánchez, Antonio, Prahallad, Anirudh, Germano, Giovanni, Bosma, Astrid, Krimpenfort, Paul, Lieftink, Cor, Steinberg, Jeffrey D., de Wit, Niels, Gonçalves-Ribeiro, Samuel, Nadal, Ernest, Bardelli, Alberto, Villanueva, Alberto, Bernards, Rene
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Journal Article
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
Dias, Matheus Henrique, Friskes, Anoek, Wang, Siying, Fernandes Neto, Joao M, van Gemert, Frank, Mourragui, Soufiane, Papagianni, Chrysa, Kuiken, Hendrik J, Mainardi, Sara, Alvarez-Villanueva, Daniel, Lieftink, Cor, Morris, Ben, Dekker, Anna, van Dijk, Emma, Wilms, Lieke H S, da Silva, Marcelo S, Jansen, Robin A, Mulero-Sánchez, Antonio, Malzer, Elke, Vidal, August, Santos, Cristina, Salazar, Ramón, Wailemann, Rosangela A M, Torres, Thompson E P, De Conti, Giulia, Raaijmakers, Jonne A, Snaebjornsson, Petur, Yuan, Shengxian, Qin, Wenxin, Kovach, John S, Armelin, Hugo A, Te Riele, Hein, van Oudenaarden, Alexander, Jin, Haojie, Beijersbergen, Roderick L, Villanueva, Alberto, Medema, Rene H, Bernards, Rene
Published in Cancer discovery (01.07.2024)
Published in Cancer discovery (01.07.2024)
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Journal Article
Genetic and compound screens uncover factors modulating cancer cell response to indisulam
Pogacar, Ziva, Groot, Kelvin, Jochems, Fleur, Dos Santos Dias, Matheus, Mulero-Sánchez, Antonio, Morris, Ben, Roosen, Mieke, Wardak, Leyma, De Conti, Giulia, Velds, Arno, Lieftink, Cor, Thijssen, Bram, Beijersbergen, Roderick L, Bernards, René, Leite de Oliveira, Rodrigo
Published in Life science alliance (01.09.2022)
Published in Life science alliance (01.09.2022)
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Journal Article
Abstract 1823: Identification of molecular determinants of vinorelbine resistance in BRAF(V600E) mutated chemorefractory metastatic colorectal cancer patients
Vecchione, Loredana, Beumer, Ines, Mulero-Sanchez, Antonio, Snel, Mireille, Pietrantonio, Filippo, Cremolini, Chiara, Loupakis, Fotios, Martinetti, Antonia, Fuca', Giovanni, Moretto, Roberto, Fontanini, Gabriella, Fassan, Matteo, Lonardi, Sara, Schirripa, Marta, Keilholz, Ulrich, Bernards, Rene'
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract B53: Differential response of distinct KRAS mutants to SHP2 inhibition
Mainardi, Sara, Bosma, Astrid, Mulero-Sánchez, Antonio, Bernards, René
Published in Molecular cancer research (01.05.2020)
Published in Molecular cancer research (01.05.2020)
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Journal Article
Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
Frank, Katrin J., Mulero-Sánchez, Antonio, Berninger, Alexandra, Ruiz-Cañas, Laura, Bosma, Astrid, Görgülü, Kıvanç, Wu, Nan, Diakopoulos, Kalliope N., Kaya-Aksoy, Ezgi, Ruess, Dietrich A., Kabacaoğlu, Derya, Schmidt, Fränze, Kohlmann, Larissa, van Tellingen, Olaf, Thijssen, Bram, van de Ven, Marieke, Proost, Natalie, Kossatz, Susanne, Weber, Wolfgang A., Sainz, Bruno, Bernards, Rene, Algül, Hana, Lesina, Marina, Mainardi, Sara
Published in Cell reports. Medicine (15.11.2022)
Published in Cell reports. Medicine (15.11.2022)
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Journal Article
Paradoxical activation of oncogenic signaling as a cancer treatment strategy
Dias, Matheus Henrique, Friskes, Anoek, Wang, Siying, Joao Manuel Henrique Fernandes Neto, Frank Van Gemert, Mourragui, Soufiane, Kuiken, Hendrik Johan, Mainardi, Sara, Alvarez-Villanueva, Daniel, Lieftink, Cor, Morris, Ben, Dekker, Anna, Emma Van Dijk, Papagianni, Chrysa, Marcelo Santos Da Silva, Jansen, Robin, Mulero-Sanchez, Antonio, Malzer, Elke, Vidal, August, Santos, Cristina, Salazar, Ramon, Wailemann, Rosangela A M, Thompson Ep Torres, De Conti, Giulia, Raaijmakers, Jonne, Snaebjornsson, Petur, Yuan, Shengxian, Qin, Wenxin, Kovach, John S, Hugo Aguirre Armelin, Hein Te Riele, Alexander Van Oudenaarden, Jin, Haojie, Beijersbergen, Roderick, Villanueva, Alberto, Medema, Rene H, Bernards, Rene
Published in bioRxiv (07.02.2023)
Published in bioRxiv (07.02.2023)
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Paper
Combined SHP2 and ERK inhibition for the treatment of KRAS-driven Pancreatic Ductal Adenocarcinoma
Ciecielski, Katrin J, Mulero-Sanchez, Antonio, Berninger, Alexandra, Laura Ruiz Canas, Bosma, Astrid, Gorgulu, Kivanc, Wu, Nan, Diakopoulos, Kalliope N, Kaya-Aksoy, Ezgi, Ruess, Dietrich A, Kabacaoglu, Derya, Schmidt, Fraenze, Heinemann, Larissa, Fan, Yuhui, Thijssen, Bram, Van De Ven, Marieke, Proost, Natalie, Kossatz, Susanne, Weber, Wolfgang A, Sainz, Bruno, Bernards, Rene, Algul, Hana, Lesina, Marina, Mainardi, Sara
Published in bioRxiv (15.12.2021)
Published in bioRxiv (15.12.2021)
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