Development of a Multiscale Mechanistic Modelling Framework Integrating Differential Cellular Kinetics of CAR-T Cell Subsets and Immunophenotypes in Cancer Patients
Salem, Ahmed M, Mugundu, Ganesh M, Singh, Aman P
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
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Journal Article
Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab
Dey, Agnish, Austin, Matthew, Kluger, Harriet M., Trunova, Nataliya, Mann, Helen, Shire, Norah, Morgan, Claire, Zhou, Diansong, Mugundu, Ganesh M.
Published in Frontiers in immunology (03.11.2022)
Published in Frontiers in immunology (03.11.2022)
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Journal Article
The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects
Tong, Jenny, Dave, Nimita, Mugundu, Ganesh M, Davis, Harold W, Gaylinn, Bruce D, Thorner, Michael O, Tschöp, Matthias H, D'Alessio, David, Desai, Pankaj B
Published in European journal of endocrinology (01.06.2013)
Published in European journal of endocrinology (01.06.2013)
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Journal Article
Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors
GUPTA, Anshul, MUGUNDU, Ganesh M, DESAI, Pankaj B, THUMMEL, Kenneth E, UNADKAT, Jashvant D
Published in Drug metabolism and disposition (01.06.2008)
Published in Drug metabolism and disposition (01.06.2008)
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Journal Article
Population Pharmacokinetic Modeling of Adavosertib (AZD1775) in Patients with Solid Tumors
Johnson, Martin, Kaschek, Daniel, Ghiorghiu, Dana, Lanke, Shankar, Miah, Kowser, Schmidt, Henning, Mugundu, Ganesh M
Published in Journal of clinical pharmacology (01.11.2024)
Published in Journal of clinical pharmacology (01.11.2024)
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Journal Article
Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-Line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer
Johnson, Martin, Serra Traynor, Carlos, Vishwanathan, Karthick, Overend, Philip, Hartmaier, Ryan, Markovets, Aleksandra, Chmielecki, Juliann, Mugundu, Ganesh M, Barrett, J Carl, Tomkinson, Helen, Ramalingam, Suresh S
Published in Clinical pharmacology and therapeutics (01.02.2024)
Published in Clinical pharmacology and therapeutics (01.02.2024)
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Journal Article
A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma
Méndez, Eduardo, Rodriguez, Cristina P, Kao, Michael C, Raju, Sharat, Diab, Ahmed, Harbison, R Alex, Konnick, Eric Q, Mugundu, Ganesh M, Santana-Davila, Rafael, Martins, Renato, Futran, Neal D, Chow, Laura Q M
Published in Clinical cancer research (15.06.2018)
Published in Clinical cancer research (15.06.2018)
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Journal Article
Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR
Liu, Li, Mugundu, Ganesh M., Kirby, Brian J., Samineni, Divya, Desai, Pankaj B., Unadkat, Jashvant D.
Published in Biopharmaceutics & drug disposition (01.05.2012)
Published in Biopharmaceutics & drug disposition (01.05.2012)
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Journal Article
Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study
Moore, Kathleen N, Chambers, Setsuko K, Hamilton, Erika P, Chen, Lee-May, Oza, Amit M, Ghamande, Sharad A, Konecny, Gottfried E, Plaxe, Steven C, Spitz, Daniel L, Geenen, Jill J J, Troso-Sandoval, Tiffany A, Cragun, Janiel M, Rodrigo Imedio, Esteban, Kumar, Sanjeev, Mugundu, Ganesh M, Lai, Zhongwu, Chmielecki, Juliann, Jones, Suzanne F, Spigel, David R, Cadoo, Karen A
Published in Clinical cancer research (01.01.2022)
Published in Clinical cancer research (01.01.2022)
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Journal Article
A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors
Falchook, Gerald S, Sachdev, Jasgit, Imedio, Esteban Rodrigo, Kumar, Sanjeev, Mugundu, Ganesh M, Jenkins, Suzanne, Chmielecki, Juliann, Jones, Suzanne, Spigel, David R, Johnson, Melissa
Published in Investigational new drugs (01.06.2023)
Published in Investigational new drugs (01.06.2023)
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Journal Article
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors
Någård, Mats, Ah-See, Mei-Lin, Strauss, James, Wise-Draper, Trisha, Safran, Howard P., Nadeau, Laura, Edenfield, William J., Lewis, Lionel D., Ottesen, Lone H., Li, Yan, Mugundu, Ganesh M.
Published in Cancer chemotherapy and pharmacology (01.09.2023)
Published in Cancer chemotherapy and pharmacology (01.09.2023)
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Journal Article
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study
Någård, Mats, Ah-See, Mei-Lin, Strauss, James, Wise-Draper, Trisha, Safran, Howard P., Nadeau, Laura, Edenfield, William J., Lewis, Lionel D., Rekić, Dinko, Dota, Corina, Ottesen, Lone H., Li, Yan, Mugundu, Ganesh M.
Published in Cancer chemotherapy and pharmacology (01.08.2023)
Published in Cancer chemotherapy and pharmacology (01.08.2023)
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Journal Article
Adavosertib in Combination with Olaparib in Patients with Refractory Solid Tumors: An Open-Label, Dose-Finding, and Dose-Expansion Phase Ib Trial
Hamilton, Erika P., Falchook, Gerald S., Wang, Judy S., Fu, Siqing, Oza, Amit M., Imedio, Esteban Rodrigo, Kumar, Sanjeev, Ottesen, Lone, Mugundu, Ganesh M., de Bruin, Elza C., O’Connor, Mark J., Jones, Suzanne F., Spigel, David R., Li, Bob T.
Published in Targeted oncology (01.11.2024)
Published in Targeted oncology (01.11.2024)
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Journal Article
Population Pharmacokinetic-Pharmacodynamic Modelling of 24-h Diastolic Ambulatory Blood Pressure Changes Mediated by Axitinib in Patients with Metastatic Renal Cell Carcinoma
Chen, Ying, Rini, Brian I., Bair, Angel H., Mugundu, Ganesh M., Pithavala, Yazdi K.
Published in Clinical pharmacokinetics (01.04.2015)
Published in Clinical pharmacokinetics (01.04.2015)
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Journal Article
Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study
Kato, Hidenori, de Souza, Paul, Kim, Sang-We, Lickliter, Jason D., Naito, Yoichi, Park, Keunchil, Kumar, Sanjeev, Mugundu, Ganesh M., Bang, Yung-Jue
Published in Targeted oncology (01.02.2020)
Published in Targeted oncology (01.02.2020)
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Journal Article
1281 Prediction of response to immunotherapy using machine learning and tumor kinetic modeling incorporating CD8 PET imaging analysis
Dey, Agnish, Ferris, Michael, Wilson, Ian, Le, William, Schmiedehausen, Kristin, Maresca, Kevin, Keliher, Edmund, Narang, Jayant, Mugundu, Ganesh M, Singh, Aman
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
245 Development and application of physiologically based pharmacokinetic – pharmacodynamic (PBPK-PD) model for dose optimization of TAK-102: GPC3 targeted CAR-T armored with IL-7 and CCL-19
Dey, Agnish, Kagehara, Hideaki, Pop-Damkov, Petar, Sumi, Eriko, Maeda, Eiki, Akaike, Takenori, Atkuri, Kondala, Suzuki, Kotaro, Ochi, Masashi, Koyama, Takafumi, Kuboki, Yasutoshi, Nakajima, Takako Eguchi, Mugundu, Ganesh M, Singh, Aman
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes
Mugundu, Ganesh M, Sallans, Larry, Guo, Yingying, Shaughnessy, Elizabeth A, Desai, Pankaj B
Published in Drug metabolism and disposition (01.02.2012)
Published in Drug metabolism and disposition (01.02.2012)
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Journal Article
Abstract CT025: Phase Ib study of adavosertib in combination with olaparib in patients with refractory solid tumors: Dose escalation
Hamilton, Erika, Falchook, Gerald S., Wang, Judy S., Fu, Siqing, Oza, Amit, Karen, So, Imedio, Esteban Rodrigo, Kumar, Sanjeev, Ottesen, Lone, Mugundu, Ganesh M., Chmielecki, Juliann, Jones, Suzanne, Spigel, David R., Li, Bob T.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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