Abstract 1806: Birinapant, a bivalent SMAC-mimetic, promotes efficient cellular IAP E3 ligase activity and formation of a pro-apoptotic RIPK1:caspase-8 complex while monovalent IAP inhibitors are less efficient - implications for therapeutic utility
Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Haimowitz, Thomas, Deng, Yijun, Mufalli, Angeline C., Seipel, Martin E., Burns, Jennifer M., Kapoor, Gurpreet S., Begley, C. Glenn, Condon, Stephen M.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 3333: Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound cIAP1 and cIAP2
Mitsuuchi, Yasuhiro, Condon, Stephen M., Neiman, Eric M., Benetatos, Christopher A., Seipel, Martin E., Kapoor, Gurpreet Singh, Mufalli, Angeline C., Yu, Guangyao, Maguire, Orla, Minderman, Hans, Mckinlay, Mark A., Graham, Martin, Weng, David, Chunduru, Srinivas
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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