FRI0296 Kzr-616, a selective inhibitor of the immunoproteasome, blocks the disease progression in multiple models of systemic lupus erythematosus (SLE)
Muchamuel, T., Anderl, J.L., Fan, R.A., Johnson, H.W.B., Kirk, C.J., Lowe, E.
Published in Annals of the rheumatic diseases (01.06.2018)
Published in Annals of the rheumatic diseases (01.06.2018)
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Interleukin 10 protects mice from lethal endotoxemia
HOWARD, M, MUCHAMUEL, T, ANDRADE, S, MENON, S
Published in The Journal of experimental medicine (01.04.1993)
Published in The Journal of experimental medicine (01.04.1993)
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Journal Article
Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice
Ishida, H, Muchamuel, T, Sakaguchi, S, Andrade, S, Menon, S, Howard, M
Published in The Journal of experimental medicine (01.01.1994)
Published in The Journal of experimental medicine (01.01.1994)
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Journal Article
Cytokine Networking in Lungs of Immunocompetent Mice in Response to Inhaled Aspergillus fumigatus
BRIELAND, Joan K, JACKSON, Craig, CHURAKOVA, Tatyana, ABRAMS, John, HARE, Roberta, O'GARRA, Anne, MENZEL, Fred, LOEBENBERG, David, CACCIAPUOTI, Anthony, HALPERN, Judy, HURST, Stephen, MUCHAMUEL, Tony, DEBETS, Reno, KASTELEIN, Rob
Published in Infection and Immunity (01.03.2001)
Published in Infection and Immunity (01.03.2001)
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POS0715 TREATMENT OF SLE PATIENTS WITH ZETOMIPZOMIB (KZR-616), A SELECTIVE INHIBITOR OF THE IMMUNOPROTEASOME, RESULTS IN CIRCULATING GENE EXPRESSION, PROTEIN LEVEL, AND IMMUNE CELL PHENOTYPIC CHANGES WITH POTENTIAL CORRELATIONS TO CLINICAL RESPONSE
Fan, A., Tuch, B., Muchamuel, T., Anderl, J., Leff, R., Henig, N., Kirk, C.
Published in Annals of the rheumatic diseases (01.06.2022)
Published in Annals of the rheumatic diseases (01.06.2022)
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Non-viral delivery of nuclear factor- B decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis
De Vry, C. G, Prasad, S., Komuves, L., Lorenzana, C., Parham, C., Le, T., Adda, S., Hoffman, J., Kahoud, N., Garlapati, R., Shyamsundar, R., Mai, K., Zhang, J., Muchamuel, T., Dajee, M., Schryver, B., McEvoy, L. M, Ehrhardt, R. O
Published in Gut (01.04.2007)
Published in Gut (01.04.2007)
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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
Basler, Michael, Aujay, Monette A, Groettrup, Marcus, Kalim, Khalid W, Shields, Jamie, Jiang, Jing, Kirk, Christopher J, Muchamuel, Tony, Suzuki, Erika, Bennett, Mark K, Ring, Eileen R, Demo, Susan D, Shwonek, Peter, Lauer, Christoph, Sylvain, Catherine, Parlati, Francesco
Published in Nature medicine (01.07.2009)
Published in Nature medicine (01.07.2009)
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D21 IMMUNE PATHWAYS IN ACUTE LUNG INJURY AND FIBROSIS: Deficiency Of Immunoproteasome Subunits Increases Alternative Polarization Of Alveolar Macrophages
Kammerl, I E, Chen, S, Vergara, E Elorduy, Irmler, M, Beckers, J, Muchamuel, T, Kirk, C, Florea, B I, Overkleeft, H S, Eickelberg, O, Meiners, S, Stoeger, T
Published in American journal of respiratory and critical care medicine (01.01.2017)
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Published in American journal of respiratory and critical care medicine (01.01.2017)
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IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Fort, Madeline M., Cheung, Jeanne, Yen, David, Li, Joana, Zurawski, Sandra M., Lo, Sylvia, Menon, Satish, Clifford, Teresa, Hunte, Brisdell, Lesley, Robin, Muchamuel, Tony, Hurst, Stephen D., Zurawski, Gerard, Leach, Michael W., Gorman, Daniel M., Rennick, Donna M.
Published in Immunity (Cambridge, Mass.) (01.12.2001)
Published in Immunity (Cambridge, Mass.) (01.12.2001)
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Journal Article
New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25
Hurst, Stephen D, Muchamuel, Tony, Gorman, Daniel M, Gilbert, Jonathan M, Clifford, Theresa, Kwan, Sylvia, Menon, Satish, Seymour, Brian, Jackson, Craig, Kung, Ted T, Brieland, Joan K, Zurawski, Sandra M, Chapman, Richard W, Zurawski, Gerard, Coffman, Robert L
Published in The Journal of immunology (1950) (01.07.2002)
Published in The Journal of immunology (1950) (01.07.2002)
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Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation
Foxman, Ellen F, Zhang, Meifen, Hurst, Stephen D, Muchamuel, Tony, Shen, Defen, Wawrousek, Eric F, Chan, Chi-Chao, Gery, Igal
Published in The Journal of immunology (1950) (01.03.2002)
Published in The Journal of immunology (1950) (01.03.2002)
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Journal Article
Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses
Cockayne, Debra A., Muchamuel, Tony, Grimaldi, J. Christopher, Muller-Steffner, Hélène, Randall, Troy D., Lund, Frances E., Murray, Richard, Schuber, Francis, Howard, Maureen C.
Published in Blood (15.08.1998)
Published in Blood (15.08.1998)
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IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production
Muchamuel, T, Menon, S, Pisacane, P, Howard, MC, Cockayne, DA
Published in The Journal of immunology (1950) (15.03.1997)
Published in The Journal of immunology (1950) (15.03.1997)
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Journal Article
Immunomodulatory Role of Endogenous Interleukin-18 in Gamma Interferon-Mediated Resolution of Replicative Legionella pneumophila Lung Infection
BRIELAND, Joan K, JACKSON, Craig, O'GARRA, Anne, HURST, Steve, LOEBENBERG, David, MUCHAMUEL, Tony, DEBETS, Reno, KASTELEIN, Rob, CHURAKOVA, Tatyana, ABRAMS, John, HARE, Roberta
Published in Infection and Immunity (01.12.2000)
Published in Infection and Immunity (01.12.2000)
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Journal Article
Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses
Cockayne, Debra A., Muchamuel, Tony, Grimaldi, J. Christopher, Muller-Steffner, Hélène, Randall, Troy D., Lund, Frances E., Murray, Richard, Schuber, Francis, Howard, Maureen C.
Published in Blood (15.08.1998)
Published in Blood (15.08.1998)
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MODIFIED RELEASE FORMULATIONS FOR OPROZOMIB (OPROZOMIB)
MANEK, Rahul Vishram, SHARMA, Sanjeev, BEJUGAM, Naveen, MUCHAMUEL, Tony, JUMAA, Mouhannad, WONG, Hansen, KIRK, Christopher J
Year of Publication 09.09.2016
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Year of Publication 09.09.2016
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