Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy
Kirschner, Tonia, Müller, Matthias P., Rauh, Daniel
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Journal Article
Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
Quambusch, Lena, Landel, Ina, Depta, Laura, Weisner, Jörn, Uhlenbrock, Niklas, Müller, Matthias P., Glanemann, Franziska, Althoff, Kristina, Siveke, Jens T., Rauh, Daniel
Published in Angewandte Chemie International Edition (19.12.2019)
Published in Angewandte Chemie International Edition (19.12.2019)
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Journal Article
KRasG12C inhibitors in clinical trials: a short historical perspective
Goebel, Lisa, Müller, Matthias P, Goody, Roger S, Rauh, Daniel
Published in MedChemComm (01.07.2020)
Published in MedChemComm (01.07.2020)
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Journal Article
Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands
Niggenaber, Janina, Heyden, Leonie, Grabe, Tobias, Müller, Matthias P, Lategahn, Jonas, Rauh, Daniel
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Journal Article
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS -Mutant Pancreatic and Colorectal Cancer
Weisner, Jörn, Landel, Ina, Reintjes, Christoph, Uhlenbrock, Niklas, Trajkovic-Arsic, Marija, Dienstbier, Niklas, Hardick, Julia, Ladigan, Swetlana, Lindemann, Marius, Smith, Steven, Quambusch, Lena, Scheinpflug, Rebekka, Depta, Laura, Gontla, Rajesh, Unger, Anke, Müller, Heiko, Baumann, Matthias, Schultz-Fademrecht, Carsten, Günther, Georgia, Maghnouj, Abdelouahid, Müller, Matthias P, Pohl, Michael, Teschendorf, Christian, Wolters, Heiner, Viebahn, Richard, Tannapfel, Andrea, Uhl, Waldemar, Hengstler, Jan G, Hahn, Stephan A, Siveke, Jens T, Rauh, Daniel
Published in Cancer research (Chicago, Ill.) (01.05.2019)
Published in Cancer research (Chicago, Ill.) (01.05.2019)
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Journal Article
Bacterial Pathogens Commandeer Rab GTPases to Establish Intracellular Niches
Stein, Mary‐Pat, Müller, Matthias P., Wandinger‐Ness, Angela
Published in Traffic (Copenhagen, Denmark) (01.12.2012)
Published in Traffic (Copenhagen, Denmark) (01.12.2012)
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Journal Article
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries
Gehrtz, Paul, Marom, Shir, Bührmann, Mike, Hardick, Julia, Kleinbölting, Silke, Shraga, Amit, Dubiella, Christian, Gabizon, Ronen, Wiese, Jan N., Müller, Matthias P., Cohen, Galit, Babaev, Ilana, Shurrush, Khriesto, Avram, Liat, Resnick, Efrat, Barr, Haim, Rauh, Daniel, London, Nir
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors
Lategahn, Jonas, Tumbrink, Hannah L., Schultz-Fademrecht, Carsten, Heimsoeth, Alena, Werr, Lisa, Niggenaber, Janina, Keul, Marina, Parmaksiz, Fatma, Baumann, Matthias, Menninger, Sascha, Zent, Eldar, Landel, Ina, Weisner, Jörn, Jeyakumar, Kirujan, Heyden, Leonie, Russ, Nicole, Müller, Fabienne, Lorenz, Carina, Brägelmann, Johannes, Spille, Inga, Grabe, Tobias, Müller, Matthias P., Heuckmann, Johannes M., Klebl, Bert M., Nussbaumer, Peter, Sos, Martin L., Rauh, Daniel
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Journal Article
Assays for Nucleotide Competitive Reversible and Irreversible Inhibitors of Ras GTPases
Jeganathan, Sadasivam, Müller, Matthias P, Ali, Imtiaz, Goody, Roger S
Published in Biochemistry (Easton) (07.08.2018)
Published in Biochemistry (Easton) (07.08.2018)
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Journal Article
Cellular model system to dissect the isoform-selectivity of Akt inhibitors
Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M, Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P, Siveke, Jens T, Rauh, Daniel
Published in Nature communications (06.09.2021)
Published in Nature communications (06.09.2021)
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Journal Article
2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach
Schehr, Miriam, Ianes, Chiara, Weisner, Jörn, Heintze, Linda, Müller, Matthias P, Pichlo, Christian, Charl, Julia, Brunstein, Elena, Ewert, Julia, Lehr, Marc, Baumann, Ulrich, Rauh, Daniel, Knippschild, Uwe, Peifer, Christian, Herges, Rainer
Published in Photochemical & photobiological sciences (2019)
Published in Photochemical & photobiological sciences (2019)
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Journal Article
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines
Grabe, Tobias, Jeyakumar, Kirujan, Niggenaber, Janina, Schulz, Tom, Koska, Sandra, Kleinbölting, Silke, Beck, Michael Edmund, Müller, Matthias P., Rauh, Daniel
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Journal Article
Targeting Her2-insYVMA with Covalent InhibitorsA Focused Compound Screening and Structure-Based Design Approach
Lategahn, Jonas, Hardick, Julia, Grabe, Tobias, Niggenaber, Janina, Jeyakumar, Kirujan, Keul, Marina, Tumbrink, Hannah L, Becker, Christian, Hodson, Luke, Kirschner, Tonia, Klövekorn, Philip, Ketzer, Julia, Baumann, Matthias, Terheyden, Susanne, Unger, Anke, Weisner, Jörn, Müller, Matthias P, van Otterlo, Willem A. L, Bauer, Sebastian, Rauh, Daniel
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Journal Article
Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions
Wiedemann, Bianca, Kamps, Dominic, Depta, Laura, Weisner, Jörn, Cvetreznik, Jana, Tomassi, Stefano, Gentz, Sascha, Hoffmann, Jan-Erik, Müller, Matthias P, Koch, Oliver, Dehmelt, Leif, Rauh, Daniel
Published in PloS one (22.06.2022)
Published in PloS one (22.06.2022)
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Journal Article
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
Goebel, Lisa, Kirschner, Tonia, Koska, Sandra, Rai, Amrita, Janning, Petra, Maffini, Stefano, Vatheuer, Helge, Czodrowski, Paul, Goody, Roger S, Müller, Matthias P, Rauh, Daniel
Published in eLife (27.03.2023)
Published in eLife (27.03.2023)
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