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MALET, Isabelle, DELELIS, Olivier, KATLAMA, Christine, CALVEZ, Vincent, MARCELIN, Anne-Geneviève, VALANTIN, Marc-Antoine, MONTES, Brigitte, SOULIE, Cathia, WIRDEN, Marc, TCHERTANOV, Luba, PEYTAVIN, Gilles, REYNES, Jacques, MOUSCADET, Jean-Francois
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain
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Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
Delelis, Olivier, Malet, Isabelle, Na, Li, Tchertanov, Luba, Calvez, Vincent, Marcelin, Anne-Genevieve, Subra, Frederic, Deprez, Eric, Mouscadet, Jean-François
Published in Nucleic acids research (01.03.2009)
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Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
Michel, Fabrice, Crucifix, Corinne, Granger, Florence, Eiler, Sylvia, Mouscadet, Jean-François, Korolev, Sergei, Agapkina, Julia, Ziganshin, Rustam, Gottikh, Marina, Nazabal, Alexis, Emiliani, Stéphane, Benarous, Richard, Moras, Dino, Schultz, Patrick, Ruff, Marc
Published in The EMBO journal (08.04.2009)
Published in The EMBO journal (08.04.2009)
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Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo
DELELIS, Olivier, THIERRY, Sylvain, TCHERTANOV, Luba, MOUSCADET, Jean-François, SUBRA, Frédéric, SIMON, Françoise, MALET, Isabelle, ALLOUI, Chakib, SAYON, Sophie, CALVEZ, Vincent, DEPREZ, Eric, MARCELIN, Anne-Geneviève
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection
Séror, Claire, Melki, Marie-Thérèse, Subra, Frédéric, Raza, Syed Qasim, Bras, Marlène, Saïdi, Héla, Nardacci, Roberta, Voisin, Laurent, Paoletti, Audrey, Law, Frédéric, Martins, Isabelle, Amendola, Alessandra, Abdul-Sater, Ali A, Ciccosanti, Fabiola, Delelis, Olivier, Niedergang, Florence, Thierry, Sylvain, Said-Sadier, Najwane, Lamaze, Christophe, Métivier, Didier, Estaquier, Jérome, Fimia, Gian Maria, Falasca, Laura, Casetti, Rita, Modjtahedi, Nazanine, Kanellopoulos, Jean, Mouscadet, Jean-François, Ojcius, David M, Piacentini, Mauro, Gougeon, Marie-Lise, Kroemer, Guido, Perfettini, Jean-Luc
Published in The Journal of experimental medicine (29.08.2011)
Published in The Journal of experimental medicine (29.08.2011)
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Relationship between the Oligomeric Status of HIV-1 Integrase on DNA and Enzymatic Activity
Guiot, Elvire, Carayon, Kevin, Delelis, Olivier, Simon, Françoise, Tauc, Patrick, Zubin, Evgenii, Gottikh, Marina, Mouscadet, Jean-François, Brochon, Jean-Claude, Deprez, Eric
Published in The Journal of biological chemistry (11.08.2006)
Published in The Journal of biological chemistry (11.08.2006)
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Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
Malet, Isabelle, Delelis, Olivier, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Mottaz, Philippe, Peytavin, Gilles, Katlama, Christine, Mouscadet, Jean-François, Calvez, Vincent, Marcelin, Anne-Genevieve
Published in Journal of antimicrobial chemotherapy (01.04.2009)
Published in Journal of antimicrobial chemotherapy (01.04.2009)
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Resistance to HIV-1 integrase inhibitors: A structural perspective
Mouscadet, Jean-François, Delelis, Olivier, Marcelin, Anne-Geneviève, Tchertanov, Luba
Published in Drug resistance updates (01.08.2010)
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Synthesis and biological evaluation of substituted quinolines: Potential treatment of protozoal and retroviral co-infections
FAKHFAKH, Mohammed A, FOURNET, Alain, PRINA, Eric, MOUSCADET, Jean-Francois, FRANCK, Xavier, HOCQUEMILLER, Reynald, FIGADERE, Bruno
Published in Bioorganic & medicinal chemistry (17.11.2003)
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Impact of the Ku complex on HIV-1 expression and latency
Manic, Gwenola, Maurin-Marlin, Aurélie, Laurent, Fanny, Vitale, Ilio, Thierry, Sylvain, Delelis, Olivier, Dessen, Philippe, Vincendeau, Michelle, Leib-Mösch, Christine, Hazan, Uriel, Mouscadet, Jean-François, Bury-Moné, Stéphanie
Published in PloS one (29.07.2013)
Published in PloS one (29.07.2013)
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Hot Spots of Integrase Genotypic Changes Leading to HIV-2 Resistance to Raltegravir
CHARPENTIER, Charlotte, ROQUEBERT, Benedicte, COLLIN, Gilles, BENARD, Antoine, DAMOND, Florence, MOUSCADET, Jean-François, BRUN-VEZINET, Françoise, DESCAMPS, Diane, DELELIS, Olivier, LARROUY, Lucile, MATHERON, Sophie, TUBIANA, Roland, KARMOCHKINE, Marina, DUVAL, Xavier, CHENE, Genevieve, STORTO, Alexandre
Published in Antimicrobial Agents and Chemotherapy (01.03.2011)
Published in Antimicrobial Agents and Chemotherapy (01.03.2011)
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Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase, RNase H, and Integrase Activities by Hydroxytropolones
DIDIERJEAN, Joël, ISEL, Catherine, QUERRE, Flore, MOUSCADET, Jean-Francois, AUBERTIN, Anne-Marie, VALNOT, Jean-Yves, PIETTRE, Serge R, MARQUET, Roland
Published in Antimicrobial Agents and Chemotherapy (01.12.2005)
Published in Antimicrobial Agents and Chemotherapy (01.12.2005)
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A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: From nucleocapsid-condensed RNA to Vpr-bridged DNA
Lyonnais, Sébastien, Gorelick, Robert J., Heniche-Boukhalfa, Fatima, Bouaziz, Serge, Parissi, Vincent, Mouscadet, Jean-François, Restle, Tobias, Gatell, Jose Maria, Le Cam, Eric, Mirambeau, Gilles
Published in Virus research (01.02.2013)
Published in Virus research (01.02.2013)
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Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors
Stranix, Brent R., Wu, Jinzi J., Milot, Guy, Beaulieu, Françis, Bouchard, Jean-Emanuel, Gouveia, Kristine, Forte, André, Garde, Seema, Wang, Zhigang, Mouscadet, Jean-François, Delelis, Olivier, Xiao, Yong
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain
Carayon, Kevin, Leh, Hervé, Henry, Etienne, Simon, Françoise, Mouscadet, Jean-François, Deprez, Eric
Published in Nucleic acids research (01.06.2010)
Published in Nucleic acids research (01.06.2010)
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Insight into the Integrase-DNA Recognition Mechanism: A SPECIFIC DNA-BINDING MODE REVEALED BY AN ENZYMATICALLY LABELED INTEGRASE
Delelis, Olivier, Carayon, Kevin, Guiot, Elvire, Leh, Hervé, Tauc, Patrick, Brochon, Jean-Claude, Mouscadet, Jean-François, Deprez, Eric
Published in The Journal of biological chemistry (10.10.2008)
Published in The Journal of biological chemistry (10.10.2008)
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Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents
BONNENFANT, Sabine, THOMAS, Claire Marie, VITA, Claudio, SUBRA, Frédéric, DEPREZ, Eric, ZOUHIRI, Fatima, DESMAËLE, Didier, D'ANGELO, Jean, MOUSCADET, Jean Francois, LEH, Hervé
Published in Journal of Virology (01.06.2004)
Published in Journal of Virology (01.06.2004)
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Biochemical properties of the xenotropic murine leukemia virus-related virus integrase
Mbemba, Gladys, Henry, Etienne, Delelis, Olivier, Bouger, Marie-Christine, Buckle, Malcolm, Mouscadet, Jean-François, Hazan, Uriel, Leh, Hervé, Bury-Moné, Stéphanie
Published in Biochimie (01.12.2014)
Published in Biochimie (01.12.2014)
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Synthesis and antiviral properties of some polyphenols related to Salvia genus
Queffélec, Clémence, Bailly, Fabrice, Mbemba, Gladys, Mouscadet, Jean-François, Hayes, Sean, Debyser, Zeger, Witvrouw, Myriam, Cotelle, Philippe
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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