BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner
Koeken, Valerie Acm, de Bree, L Charlotte J, Mourits, Vera P, Moorlag, Simone Jcfm, Walk, Jona, Cirovic, Branko, Arts, Rob Jw, Jaeger, Martin, Dijkstra, Helga, Lemmers, Heidi, Joosten, Leo Ab, Benn, Christine S, van Crevel, Reinout, Netea, Mihai G
Published in The Journal of clinical investigation (01.10.2020)
Published in The Journal of clinical investigation (01.10.2020)
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Journal Article
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils
Moorlag, Simone J.C.F.M., Rodriguez-Rosales, Yessica Alina, Gillard, Joshua, Fanucchi, Stephanie, Theunissen, Kate, Novakovic, Boris, de Bont, Cynthia M., Negishi, Yutaka, Fok, Ezio T., Kalafati, Lydia, Verginis, Panayotis, Mourits, Vera P., Koeken, Valerie A.C.M., de Bree, L. Charlotte J., Pruijn, Ger J.M., Fenwick, Craig, van Crevel, Reinout, Joosten, Leo A.B., Joosten, Irma, Koenen, Hans, Mhlanga, Musa M., Diavatopoulos, Dimitri A., Chavakis, Triantafyllos, Netea, Mihai G.
Published in Cell reports (Cambridge) (17.11.2020)
Published in Cell reports (Cambridge) (17.11.2020)
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Journal Article
Circadian rhythm influences induction of trained immunity by BCG vaccination
de Bree, L Charlotte J, Mourits, Vera P, Koeken, Valerie Acm, Moorlag, Simone Jcfm, Janssen, Robine, Folkman, Lukas, Barreca, Daniele, Krausgruber, Thomas, Fife-Gernedl, Victoria, Novakovic, Boris, Arts, Rob Jw, Dijkstra, Helga, Lemmers, Heidi, Bock, Christoph, Joosten, Leo Ab, van Crevel, Reinout, Benn, Christine S, Netea, Mihai G
Published in The Journal of clinical investigation (01.10.2020)
Published in The Journal of clinical investigation (01.10.2020)
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Journal Article
The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan
Keating, Samuel T., Groh, Laszlo, van der Heijden, Charlotte D.C.C., Rodriguez, Hanah, dos Santos, Jéssica C., Fanucchi, Stephanie, Okabe, Jun, Kaipananickal, Harikrishnan, van Puffelen, Jelmer H., Helder, Leonie, Noz, Marlies P., Matzaraki, Vasiliki, Li, Yang, de Bree, L. Charlotte J., Koeken, Valerie A.C.M., Moorlag, Simone J.C.F.M., Mourits, Vera P., Domínguez-Andrés, Jorge, Oosting, Marije, Bulthuis, Elianne P., Koopman, Werner J.H., Mhlanga, Musa, El-Osta, Assam, Joosten, Leo A.B., Netea, Mihai G., Riksen, Niels P.
Published in Cell reports (Cambridge) (21.04.2020)
Published in Cell reports (Cambridge) (21.04.2020)
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Journal Article
The influence of the gut microbiome on BCG-induced trained immunity
Stražar, Martin, Mourits, Vera P, Koeken, Valerie A C M, de Bree, L Charlotte J, Moorlag, Simone J C F M, Joosten, Leo A B, van Crevel, Reinout, Vlamakis, Hera, Netea, Mihai G, Xavier, Ramnik J
Published in Genome Biology (22.09.2021)
Published in Genome Biology (22.09.2021)
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Journal Article
Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination
Koeken, Valerie A. C. M, Qi, Cancan, Mourits, Vera P, de Bree, L. Charlotte J, Moorlag, Simone J. C. F. M, Sonawane, Vidhisha, Lemmers, Heidi, Dijkstra, Helga, Joosten, Leo A. B, van Laarhoven, Arjan, Xu, Cheng-Jian, van Crevel, Reinout, Netea, Mihai G, Li, Yang
Published in PLoS biology (12.09.2022)
Published in PLoS biology (12.09.2022)
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Journal Article
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
Li, Wenchao, Moorlag, Simone J.C.F.M., Koeken, Valerie A.C.M., Röring, Rutger J., de Bree, L. Charlotte J., Mourits, Vera P., Gupta, Manoj K., Zhang, Bowen, Fu, Jianbo, Zhang, Zhenhua, Grondman, Inge, van Meijgaarden, Krista E., Zhou, Liang, Alaswad, Ahmed, Joosten, Leo A.B., van Crevel, Reinout, Xu, Cheng-Jian, Netea, Mihai G., Li, Yang
Published in Cell reports (Cambridge) (30.05.2023)
Published in Cell reports (Cambridge) (30.05.2023)
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Journal Article
Dimethyl itaconate induces long-term innate immune responses and confers protection against infection
Ferreira, Anaísa V., Kostidis, Sarantos, Groh, Laszlo A., Koeken, Valerie A.C.M., Bruno, Mariolina, Baydemir, Ilayda, Kilic, Gizem, Bulut, Özlem, Andriopoulou, Theano, Spanou, Victoria, Synodinou, Kalliopi D., Gkavogianni, Theologia, Moorlag, Simone J.C.F.M., Charlotte de Bree, L., Mourits, Vera P., Matzaraki, Vasiliki, Koopman, Werner J.H., van de Veerdonk, Frank L., Renieris, Georgios, Giera, Martin, Giamarellos-Bourboulis, Evangelos J., Novakovic, Boris, Domínguez-Andrés, Jorge
Published in Cell reports (Cambridge) (27.06.2023)
Published in Cell reports (Cambridge) (27.06.2023)
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Journal Article
The role of Toll‐like receptor 10 in modulation of trained immunity
Mourits, Vera P., Arts, Rob J.W., Novakovic, Boris, Matzaraki, Vasiliki, Bree, L. Charlotte J., Koeken, Valerie A.C.M., Moorlag, Simone J.C.F.M., Puffelen, Jelmer H., Groh, Laszlo, Heijden, Charlotte D.C.C., Keating, Sam T., Netea, Mihai G., Oosting, Marije, Joosten, Leo A.B.
Published in Immunology (01.03.2020)
Published in Immunology (01.03.2020)
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Journal Article
Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study
Moorlag, Simone J.C.F.M., van Deuren, Rosanne C., van Werkhoven, Cornelis H., Jaeger, Martin, Debisarun, Priya, Taks, Esther, Mourits, Vera P., Koeken, Valerie A.C.M., de Bree, L. Charlotte J., ten Doesschate, Thijs, Cleophas, Maartje C., Smeekens, Sanne, Oosting, Marije, van de Veerdonk, Frank L., Joosten, Leo A.B., ten Oever, Jaap, van der Meer, Jos W.M., Curtis, Nigel, Aaby, Peter, Stabell-Benn, Christine, Giamarellos-Bourboulis, Evangelos J., Bonten, Marc, van Crevel, Reinout, Netea, Mihai G.
Published in Cell Reports Medicine (25.08.2020)
Published in Cell Reports Medicine (25.08.2020)
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The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men
Kilic, Gizem, Bulut, Ozlem, Jaeger, Martin, ter Horst, Rob, Koeken, Valerie A. C. M., Moorlag, Simone J. C. F. M., Mourits, Vera P., de Bree, Charlotte, Domínguez-Andrés, Jorge, Joosten, Leo A. B., Netea, Mihai G.
Published in Frontiers in immunology (09.08.2021)
Published in Frontiers in immunology (09.08.2021)
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Journal Article
BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations
Wang, Yue, van Crevel, Reinout, Netea, Mihai G., Lemmers, Heidi, Dijkstra, Helga, Xu, Xiaoli, Chu, Wern Cui, Moorlag, Simone J. C. F. M., de Bree, L. Charlotte J., Koeken, Valerie A. C. M., Mourits, Vera P., Joosten, Leo A. B.
Published in Journal of Immunology Research (2020)
Published in Journal of Immunology Research (2020)
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Journal Article
The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses
Kuijpers, Yunus, Chu, Xiaojing, Jaeger, Martin, Moorlag, Simone J C F M, Koeken, Valerie A C M, Zhang, Bowen, de Nooijer, Aline, Grondman, Inge, Gupta, Manoj Kumar, Janssen, Nico, Mourits, Vera P, de Bree, L Charlotte J, de Mast, Quirijn, van de Veerdonk, Frank L, Joosten, Leo A B, Li, Yang, Netea, Mihai G, Xu, Cheng-Jian
Published in Frontiers in immunology (12.05.2022)
Published in Frontiers in immunology (12.05.2022)
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Journal Article
Glutathione Metabolism Contributes to the Induction of Trained Immunity
Ferreira, Anaisa V, Koeken, Valerie A C M, Matzaraki, Vasiliki, Kostidis, Sarantos, Alarcon-Barrera, Juan Carlos, de Bree, L Charlotte J, Moorlag, Simone J C F M, Mourits, Vera P, Novakovic, Boris, Giera, Martin A, Netea, Mihai G, Domínguez-Andrés, Jorge
Published in Cells (Basel, Switzerland) (21.04.2021)
Published in Cells (Basel, Switzerland) (21.04.2021)
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Journal Article
Lysine methyltransferase G9a is an important modulator of trained immunity
Mourits, Vera P, Puffelen, Jelmer H, Novakovic, Boris, Bruno, Mariolina, Ferreira, Anaísa V, Arts, Rob JW, Groh, Laszlo, Crișan, Tania O, Zwaag, Jelle, Jentho, Elisa, Kox, Matthijs, Pickkers, Peter, Veerdonk, Frank L, Weis, Sebastian, Oosterwijk, Egbert, Vermeulen, Sita H, Netea, Mihai G, Joosten, Leo AB
Published in Clinical & translational immunology (2021)
Published in Clinical & translational immunology (2021)
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Journal Article
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition
Priem, Bram, van Leent, Mandy M.T., Teunissen, Abraham J.P., Sofias, Alexandros Marios, Mourits, Vera P., Willemsen, Lisa, Klein, Emma D., Oosterwijk, Roderick S., Meerwaldt, Anu E., Munitz, Jazz, Prévot, Geoffrey, Vera Verschuur, Anna, Nauta, Sheqouia A., van Leeuwen, Esther M., Fisher, Elizabeth L., de Jong, Karen A.M., Zhao, Yiming, Toner, Yohana C., Soultanidis, Georgios, Calcagno, Claudia, Bomans, Paul H.H., Friedrich, Heiner, Sommerdijk, Nico, Reiner, Thomas, Duivenvoorden, Raphaël, Zupančič, Eva, Di Martino, Julie S., Kluza, Ewelina, Rashidian, Mohammad, Ploegh, Hidde L., Dijkhuizen, Rick M., Hak, Sjoerd, Pérez-Medina, Carlos, Bravo-Cordero, Jose Javier, de Winther, Menno P.J., Joosten, Leo A.B., van Elsas, Andrea, Fayad, Zahi A., Rialdi, Alexander, Torre, Denis, Guccione, Ernesto, Ochando, Jordi, Netea, Mihai G., Griffioen, Arjan W., Mulder, Willem J.M.
Published in Cell (29.10.2020)
Published in Cell (29.10.2020)
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Trained immunity as a novel therapeutic strategy
Mourits, Vera P, Wijkmans, Jac CHM, Joosten, Leo AB, Netea, Mihai G
Published in Current opinion in pharmacology (01.08.2018)
Published in Current opinion in pharmacology (01.08.2018)
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Journal Article
CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors
Bar-Ephraim, Yotam E, Koning, Jasper J, Burniol Ruiz, Estefany, Konijn, Tanja, Mourits, Vera P, Lakeman, Kim A, Boon, Louis, Bögels, Marijn, van Maanen, J Peter, Den Haan, Joke M M, van Egmond, Marjolein, Bouma, Gerd, Reijmers, Rogier M, Mebius, Reina E
Published in The Journal of immunology (1950) (01.01.2019)
Published in The Journal of immunology (1950) (01.01.2019)
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Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein
Keating, Samuel T., Groh, Laszlo, Thiem, Kathrin, Bekkering, Siroon, Li, Yang, Matzaraki, Vasiliki, van der Heijden, Charlotte D. C. C., van Puffelen, Jelmer H., Lachmandas, Ekta, Jansen, Trees, Oosting, Marije, de Bree, L. Charlotte J., Koeken, Valerie A. C. M., Moorlag, Simone J. C. F. M., Mourits, Vera P., van Diepen, Janna, Strienstra, Rinke, Novakovic, Boris, Stunnenberg, Hendrik G., van Crevel, Reinout, Joosten, Leo A. B., Netea, Mihai G., Riksen, Niels P.
Published in Journal of molecular medicine (Berlin, Germany) (01.06.2020)
Published in Journal of molecular medicine (Berlin, Germany) (01.06.2020)
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Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Moorlag, Simone J C F M, Folkman, Lukas, Ter Horst, Rob, Krausgruber, Thomas, Barreca, Daniele, Schuster, Linda C, Fife, Victoria, Matzaraki, Vasiliki, Li, Wenchao, Reichl, Stephan, Mourits, Vera P, Koeken, Valerie A C M, de Bree, L Charlotte J, Dijkstra, Helga, Lemmers, Heidi, van Cranenbroek, Bram, van Rijssen, Esther, Koenen, Hans J P M, Joosten, Irma, Xu, Cheng-Jian, Li, Yang, Joosten, Leo A B, van Crevel, Reinout, Netea, Mihai G, Bock, Christoph
Published in Immunity (Cambridge, Mass.) (09.01.2024)
Published in Immunity (Cambridge, Mass.) (09.01.2024)
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