Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan S, Nguyen, Kathy K, Liu, Qingxiang, Slater, Rebecca, Rock, Brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J, Malik, Fady I, Reagan, Jeff D, Luptak, Ivan
Published in Circulation. Heart failure (01.03.2022)
Published in Circulation. Heart failure (01.03.2022)
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Journal Article
Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity
Singh, Rohit R., Slater, Rebecca E., Wang, Jinghong, Wang, Chen, Guo, Qi, Motani, Alykhan S., Hartman, James J., Sadayappan, Sakthivel, Ason, Brandon L.
Published in JACC. Basic to translational science (01.10.2022)
Published in JACC. Basic to translational science (01.10.2022)
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Journal Article
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor
Gu, Wei, Winters, Katherine A, Motani, Alykhan S, Komorowski, Renée, Zhang, Ying, Liu, Qingxiang, Wu, Xiaosu, Rulifson, Ingrid C, Sivits, Jr, Glenn, Graham, Melissa, Yan, Hai, Wang, Paul, Moore, Steve, Meng, Tina, Lindberg, Richard A, Véniant, Murielle M
Published in American journal of physiology: endocrinology and metabolism (01.10.2010)
Published in American journal of physiology: endocrinology and metabolism (01.10.2010)
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Journal Article
Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo
Motani, Alykhan, Wang, Zhulun, Conn, Marion, Siegler, Karen, Zhang, Ying, Liu, Qingxiang, Johnstone, Sheree, Xu, Haoda, Thibault, Steve, Wang, Yingcai, Fan, Pingchen, Connors, Richard, Le, Hoa, Xu, Guifen, Walker, Nigel, Shan, Bei, Coward, Peter
Published in The Journal of biological chemistry (20.03.2009)
Published in The Journal of biological chemistry (20.03.2009)
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Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes
Toda, Narihiro, Hao, Xiaolin, Ogawa, Yasuyuki, Oda, Kozo, Yu, Ming, Fu, Zice, Chen, Yi, Kim, Yongjae, Lizarzaburu, Mike, Lively, Sarah, Lawlis, Shauna, Murakoshi, Michiko, Nara, Futoshi, Watanabe, Nobuaki, Reagan, Jeff D, Tian, Hui, Fu, Angela, Motani, Alykhan, Liu, Qingxiang, Lin, Yi-Jyun, Zhuang, Run, Xiong, Yumei, Fan, Peter, Medina, Julio, Li, Leping, Izumi, Masanori, Okuyama, Ryo, Shibuya, Satoshi
Published in ACS medicinal chemistry letters (08.08.2013)
Published in ACS medicinal chemistry letters (08.08.2013)
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Journal Article
CCR8 Is Not Essential for the Development of Inflammation in a Mouse Model of Allergic Airway Disease
Chung, Chan D, Kuo, Frederick, Kumer, Jeffrey, Motani, Alykhan S, Lawrence, Christopher E, Henderson, William R., Jr, Venkataraman, Chandrasekar
Published in The Journal of immunology (1950) (01.01.2003)
Published in The Journal of immunology (1950) (01.01.2003)
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Journal Article
Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF
Gordon A. A. Ferns, Raines, Elaine W., Sprugel, Katherine H., Motani, Alykhan S., Reidy, Michael A., Ross, Russell
Published in Science (American Association for the Advancement of Science) (06.09.1991)
Published in Science (American Association for the Advancement of Science) (06.09.1991)
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Journal Article
Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Journal Article
Evaluation of AMG 076, a potent and selective MCHR 1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Journal Article
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility
Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Abstract 9199: A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics or Diastolic Function
He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan, Nguyen, Khanh K, Liu, Qingxiang, Slater, Rebecca, rock, brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J, Malik, Fady I, reagan, jeff D, Luptak, Ivan
Published in Circulation (New York, N.Y.) (16.11.2021)
Published in Circulation (New York, N.Y.) (16.11.2021)
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Journal Article
INT131: A Selective Modulator of PPARγ
Motani, Alykhan, Wang, Zhulun, Weiszmann, Jennifer, McGee, Lawrence R., Lee, Gary, Liu, Qingxiang, Staunton, Jocelyn, Fang, Zexu, Fuentes, Helen, Lindstrom, Michelle, Liu, Jinsong, Biermann, Donna H.T., Jaen, Juan, Walker, Nigel P.C., Learned, R. Marc, Chen, Jin-Long, Li, Yang
Published in Journal of molecular biology (13.03.2009)
Published in Journal of molecular biology (13.03.2009)
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Journal Article
Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity
Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao
Published in Bioorganic & medicinal chemistry (15.02.2013)
Published in Bioorganic & medicinal chemistry (15.02.2013)
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Journal Article
Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction
Wang, Wei, MD, PhD, Zhang, Liyan, PhD, Battiprolu, Pavan K., PhD, Fukushima, Arata, MD, PhD, Nguyen, Khanh, BS, Milner, Kenneth, BS, Gupta, Abhishek, PhD, Altamimi, Tariq, PhD, Byrne, Nikole, BS, Mori, Jun, MD, PhD, Alrob, Osama Abo, PhD, Wagg, Cory, Fillmore, Natasha, PhD, Wang, Shao-hua, MD, PhD, Liu, Dongming M., BS, Fu, Angela, BS, Lu, Jenny Yinglin, BS, Chaves, Mary, MS, Motani, Alykhan, PhD, Ussher, John R., PhD, Reagan, Jeff D., PhD, Dyck, Jason R.B., PhD, Lopaschuk, Gary D., PhD
Published in JACC. Basic to translational science (01.06.2019)
Published in JACC. Basic to translational science (01.06.2019)
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Journal Article
Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4
Wang, Yingcai, Connors, Richard, Fan, Pingchen, Wang, Xiaodong, Wang, Zhongyu, Liu, Jiwen, Kayser, Frank, Medina, Julio C, Johnstone, Sheree, Xu, Haoda, Thibault, Stephen, Walker, Nigel, Conn, Marion, Zhang, Ying, Liu, Qingxiang, Grillo, Mark P, Motani, Alykhan, Coward, Peter, Wang, Zhulun
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
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Journal Article
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
Mihalic, Jeffrey T., Fan, Pingchen, Chen, Xiaoqi, Chen, Xi, Fu, Ying, Motani, Alykhan, Liang, Lingming, Lindstrom, Michelle, Tang, Liang, Chen, Jin-Long, Jaen, Juan, Dai, Kang, Li, Leping
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity
Yu, Ming, Lizarzaburu, Mike, Beckmann, Holger, Connors, Richard, Dai, Kang, Haller, Katrin, Li, Cong, Liang, Lingming, Lindstrom, Michelle, Ma, Ji, Motani, Alykhan, Wanska, Malgorzata, Zhang, Alex, Li, Leping, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Discovery of INT131: A selective PPARI3 modulator that enhances insulin sensitivity
Taygerly, Joshua, McGee, Lawrence, Rubenstein, Steven, Houze, Jonathan, Cushing, Timothy, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc, Jaen, Juan, Miao, Shichang, Timmermans, Pieter, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao
Published in Bioorganic & medicinal chemistry (01.02.2013)
Published in Bioorganic & medicinal chemistry (01.02.2013)
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