Oncogenic protein interfaces: small molecules, big challenges
Nero, Tracy L, Morton, Craig J, Holien, Jessica K, Wielens, Jerome, Parker, Michael W
Published in Nature reviews. Cancer (01.04.2014)
Published in Nature reviews. Cancer (01.04.2014)
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Journal Article
Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation
Morton, Craig J, Sani, Marc-Antoine, Parker, Michael W, Separovic, Frances
Published in Chemical reviews (10.07.2019)
Published in Chemical reviews (10.07.2019)
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Journal Article
Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Brooks, Andrew J., Dai, Wei, O'Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E., Waters, Michael J.
Published in Science (American Association for the Advancement of Science) (16.05.2014)
Published in Science (American Association for the Advancement of Science) (16.05.2014)
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Journal Article
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2019)
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Journal Article
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Braig, David, Nero, Tracy L, Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R, Morton, Craig J, Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A, Mellett, Natalie A, Miles, Luke A, Du, Xiao-Jun, Meikle, Peter J, Huber-Lang, Markus, Stark, G Björn, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U
Published in Nature communications (23.01.2017)
Published in Nature communications (23.01.2017)
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Journal Article
Risk assessment of the environmental impact of Norwegian Atlantic salmon farming
Taranger, Geir Lasse, Karlsen, Oerjan, Bannister, Raymond John, Glover, Kevin Alan, Husa, Vivian, Karlsbakk, Egil, Kvamme, Bjoern Olav, Boxaspen, Karin Kroon, Bjoern, Pal Arne, Finstad, Bengt, Madhun, Abdullah Sami, Morton, H Craig, Svasand, Terje
Published in ICES journal of marine science (01.03.2015)
Published in ICES journal of marine science (01.03.2015)
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Journal Article
Customer perceptions of quality of service in public transport: Evidence for bus transit in Scotland
Morton, Craig, Caulfield, Brian, Anable, Jillian
Published in Case studies on transport policy (01.09.2016)
Published in Case studies on transport policy (01.09.2016)
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Journal Article
The biological function of an insect antifreeze protein simulated by molecular dynamics
Kuiper, Michael J, Morton, Craig J, Abraham, Sneha E, Gray-Weale, Angus
Published in eLife (07.05.2015)
Published in eLife (07.05.2015)
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Journal Article
C-reactive protein, immunothrombosis and venous thromboembolism
Dix, Caroline, Zeller, Johannes, Stevens, Hannah, Eisenhardt, Steffen U., Shing, Karen S. Cheung Tung, Nero, Tracy L., Morton, Craig J., Parker, Michael W., Peter, Karlheinz, McFadyen, James D.
Published in Frontiers in immunology (13.09.2022)
Published in Frontiers in immunology (13.09.2022)
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Journal Article
Protein structure and computational drug discovery
Nero, Tracy L, Parker, Michael W, Morton, Craig J
Published in Biochemical Society transactions (19.10.2018)
Published in Biochemical Society transactions (19.10.2018)
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Journal Article
Nanopore sequencing provides snapshots of the genetic variation within salmonid alphavirus-3 (SAV3) during an ongoing infection in Atlantic salmon (Salmo salar) and brown trout (Salmo trutta)
Roh, HyeongJin, Skaftnesmo, Kai Ove, Kannimuthu, Dhamotharan, Madhun, Abdullah, Patel, Sonal, Kvamme, Bjørn Olav, Morton, H. Craig, Grove, Søren
Published in Veterinary research (Paris) (03.09.2024)
Published in Veterinary research (Paris) (03.09.2024)
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Journal Article
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant
Metcalfe, Riley D., Hanssen, Eric, Fung, Ka Yee, Aizel, Kaheina, Kosasih, Clara C., Zlatic, Courtney O., Doughty, Larissa, Morton, Craig J., Leis, Andrew P., Parker, Michael W., Gooley, Paul R., Putoczki, Tracy L., Griffin, Michael D. W.
Published in Nature communications (20.11.2023)
Published in Nature communications (20.11.2023)
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Journal Article
Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins
Lawrence, Sara L., Gorman, Michael A., Feil, Susanne C., Mulhern, Terrence D., Kuiper, Michael J., Ratner, Adam J., Tweten, Rodney K., Morton, Craig J., Parker, Michael W.
Published in Structure (London) (06.09.2016)
Published in Structure (London) (06.09.2016)
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Journal Article
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement
Metcalfe, Riley D., Aizel, Kaheina, Zlatic, Courtney O., Nguyen, Paul M., Morton, Craig J., Lio, Daisy Sio-Seng, Cheng, Heung-Chin, Dobson, Renwick C.J., Parker, Michael W., Gooley, Paul R., Putoczki, Tracy L., Griffin, Michael D.W.
Published in The Journal of biological chemistry (12.06.2020)
Published in The Journal of biological chemistry (12.06.2020)
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Journal Article
Genetic Variants in ERAP1 and ERAP2 Associated With Immune‐Mediated Diseases Influence Protein Expression and the Isoform Profile
Hanson, Aimee L., Cuddihy, Thomas, Haynes, Katelin, Loo, Dorothy, Morton, Craig J., Oppermann, Udo, Leo, Paul, Thomas, Gethin P., Lê Cao, Kim‐Anh, Kenna, Tony J., Brown, Matthew A.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2018)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2018)
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Journal Article
Rational Design of an Organometallic Glutathione Transferase Inhibitor
Ang, Wee Han, Parker, Lorien J, De Luca, Anastasia, Juillerat-Jeanneret, Lucienne, Morton, Craig J, Lo Bello, Mario, Parker, Michael W, Dyson, Paul J
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Journal Article
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein
Zeller, Johannes, Cheung Tung Shing, Karen S, Nero, Tracy L, McFadyen, James D, Krippner, Guy, Bogner, Balázs, Kreuzaler, Sheena, Kiefer, Jurij, Horner, Verena K, Braig, David, Danish, Habiba, Baratchi, Sara, Fricke, Mark, Wang, Xiaowei, Kather, Michel G, Kammerer, Bernd, Woollard, Kevin J, Sharma, Prerna, Morton, Craig J, Pietersz, Geoffrey, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U
Published in EMBO molecular medicine (11.01.2023)
Published in EMBO molecular medicine (11.01.2023)
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Journal Article
Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria
Abrahamsen, Hunter L, Sanford, Tristan C, Collamore, Casie E, Johnstone, Bronte A, Coyne, Michael J, García-Bayona, Leonor, Christie, Michelle P, Evans, Jordan C, Farrand, Allison J, Flores, Katia, Morton, Craig J, Parker, Michael W, Comstock, Laurie E, Tweten, Rodney K
Published in Nature communications (12.06.2024)
Published in Nature communications (12.06.2024)
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Journal Article
Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals
Spackman, Peter R., Yu, Li‐Juan, Morton, Craig J., Parker, Michael W., Bond, Charles S., Spackman, Mark A., Jayatilaka, Dylan, Thomas, Sajesh P.
Published in Angewandte Chemie International Edition (18.11.2019)
Published in Angewandte Chemie International Edition (18.11.2019)
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Journal Article