Making Better Drugs: Decision Gates in Non-Clinical Drug Development
Pritchard, J. Fred, Jurima-Romet, Malle, Reimer, Mark L. J, Mortimer, Elisabeth, Rolfe, Brenda, Cayen, Mitchell N
Published in Nature reviews. Drug discovery (01.07.2003)
Published in Nature reviews. Drug discovery (01.07.2003)
Get full text
Journal Article
The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout
Pike, Andy, Storer, R. Ian, Owen, Robert M., Armstrong, Emma, Benn, Caroline L., Bictash, Magda, Cheung, Kathy F. K., Costelloe, Kathryn, Dardennes, Emmanuel, Impey, Emma, Milliken, Philip H., Mortimer-Cassen, Elisabeth, Pearcee, Hannah J.
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
Get full text
Journal Article
An Industry Perspective on the 2017 EMA Guideline on First-in-Human and Early Clinical Trials
DeGeorge, Joseph, Robertson, Sarah, Butler, Lynne, Derzi, Mazin, Stoch, S Aubrey, Diaz, Dolores, Hartke, James, Guzzie-Peck, Peggy, Mortimer-Cassen, Elisabeth, Bogdanffy, Matthew, Will, Yvonne, Greene, Nigel
Published in Clinical pharmacology and therapeutics (01.04.2018)
Published in Clinical pharmacology and therapeutics (01.04.2018)
Get more information
Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)
Owen, Robert M, Blakemore, David, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A, Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C, Reynolds, David S, Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
Get full text
Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABA(A) Positive Allosteric Modulator (PF-06372865)
Owen, Robert M., Blakemore, David, Cao, Lishuan, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R., Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A., Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C., Reynolds, David S., Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S., Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
Get full text
Journal Article
Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective
Butler, Lynne D., Guzzie-Peck, Peggy, Hartke, James, Bogdanffy, Matthew S., Will, Yvonne, Diaz, Dolores, Mortimer-Cassen, Elisabeth, Derzi, Mazin, Greene, Nigel, DeGeorge, Joseph J.
Published in Regulatory toxicology and pharmacology (31.07.2017)
Published in Regulatory toxicology and pharmacology (31.07.2017)
Get full text
Journal Article
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation
Prior, Helen, Baldrick, Paul, Beken, Sonja, Booler, Helen, Bower, Nancy, Brooker, Paul, Brown, Paul, Burlinson, Brian, Burns-Naas, Leigh Ann, Casey, Warren, Chapman, Melissa, Clarke, David, de Haan, Lolke, Doehr, Olaf, Downes, Noel, Flaherty, Meghan, Gellatly, Nichola, Moesgaard, Sophia Gry, Harris, Jennifer, Holbrook, Mark, Hui, Julia, Jones, David, Jones, Keith, Kedar, Hilla, Mahl, Andreas, Manninen, Alli, McGuire, Aidan, Mortimer-Cassen, Elisabeth, Peraza, Marjorie, Pugsley, Michael K., Richard, Jacques, Roberts, Ruth, Roosen, Wendy, Rothfuss, Andreas, Schoenmakers, Ankie, Sewell, Fiona, Weaver, Richard, Weir, Lucinda, Wolfreys, Alison, Kimber, Ian
Published in Regulatory toxicology and pharmacology (01.06.2020)
Published in Regulatory toxicology and pharmacology (01.06.2020)
Get full text
Journal Article
The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of goutThe authors declare no competing interests.Electronic supplementary information (ESI) available: URAT1 assay protocol, experimental procedures, HPLC, MS, 1H NMR, and 13C NMR spectra of key compounds. See DOI: 10.1039/c6md00190d
Storer, R. Ian, Owen, Robert M, Pike, Andy, Benn, Caroline L, Armstrong, Emma, Blakemore, David C, Bictash, Magda, Costelloe, Kathryn, Impey, Emma, Milliken, Philip H, Mortimer-Cassen, Elisabeth, Pearce, Hannah J, Pibworth, Benjamin, Toschi, Gianna
Year of Publication 11.08.2016
Year of Publication 11.08.2016
Get full text
Journal Article
The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of goutThe authors declare no competing interests.Electronic supplementary information (ESI) available: URAT1 assay protocol, experimental procedures, HPLC, MS, 1H NMR, and 13C NMR spectra of key compounds. See DOI: 10.1039/c6md00191b
Pike, Andy, Storer, R. Ian, Owen, Robert M, Armstrong, Emma, Benn, Caroline L, Bictash, Magda, Cheung, Kathy F. K, Costelloe, Kathryn, Dardennes, Emmanuel, Impey, Emma, Milliken, Philip H, Mortimer-Cassen, Elisabeth, Pearce, Hannah J
Year of Publication 11.08.2016
Year of Publication 11.08.2016
Get full text
Journal Article
The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout
Storer, R. Ian, Owen, Robert M., Pike, Andy, Benn, Caroline L., Armstrong, Emma, Blakemore, David C., Bictash, Magda, Costelloe, Kathryn, Impey, Emma, Milliken, Philip H., Mortimer-Cassen, Elisabeth, Pearce, Hannah J., Pibworth, Benjamin, Toschi, Gianna
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
Get full text
Journal Article