CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro
Tsuji, Toshiya, Sapinoso, Lisa M, Tran, Tam, Gaffney, Bonny, Wong, Lilly, Sankar, Sabita, Raymon, Heather K, Mortensen, Deborah S, Xu, Shuichan
Published in Oncotarget (26.09.2017)
Published in Oncotarget (26.09.2017)
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Journal Article
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma
Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.
Published in Molecular oncology (01.02.2023)
Published in Molecular oncology (01.02.2023)
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Journal Article
The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas
GINI, Beatrice, ZANCA, Ciro, SHAOJUN ZHU, TANAKA, Kazuhiro, BABIC, Ivan, AKHAVAN, David, LIN, Kelly, ASSUNCAO, Alvaro, YUCHAO GU, BONETTI, Bruno, MORTENSEN, Deborah S, SHUICHAN XU, DELIANG GUO, RAYMON, Heather K, CAVENEE, Webster K, FURNARI, Frank B, JAMES, C. David, KROEMER, Guido, HEATH, James R, HEGE, Kristen, CHOPRA, Rajesh, CLOUGHESY, Timothy F, MISCHEL, Paul S, MATSUTANI, Tomoo, MASUI, Kenta, IKEGAMI, Shiro, HUIJUN YANG, NATHANSON, David, VILLA, Genaro R, SHACKELFORD, David
Published in Clinical cancer research (15.10.2013)
Published in Clinical cancer research (15.10.2013)
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Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase
Mortensen, Deborah S., Sapienza, John, Lee, Branden G.S., Perrin-Ninkovic, Sophie M., Harris, Roy, Shevlin, Graziella, Parnes, Jason S., Whitefield, Brandon, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Peng, Sophie, Gamez, Jim C., Leisten, Jim, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Discovery and SAR exploration of a novel series of imidazo[4,5- b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Harris, Roy, Lee, Branden G.S., Shevlin, Graziella, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis
Tasneen, Rokeya, Mortensen, Deborah S, Converse, Paul J, Urbanowski, Michael E, Upton, Anna, Fotouhi, Nader, Nuermberger, Eric, Hawryluk, Natalie
Published in Antimicrobial agents and chemotherapy (17.06.2021)
Published in Antimicrobial agents and chemotherapy (17.06.2021)
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Journal Article
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation
Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001
Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Discovery of an Azabicyclo[2.1.1]hexane Piperazinium Salt and Its Application in Medicinal Chemistry via a Rearrangement
He, Chi, Ba, Xiaochu, Shunatona, Hunter P., Edwards, Jacob T., Li, Yi-Xin, Keller, Taylor M., Sommer, Roger D., Zapf, Christoph W., Mortensen, Deborah S.
Published in Organic letters (28.06.2024)
Published in Organic letters (28.06.2024)
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Journal Article
Correction to “Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation”
Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S., Brazeau, Jean-François
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanced solid tumors or multiple myeloma
Bendell, Johanna C., Kelley, Robin K., Shih, Kent C., Grabowsky, Jennifer A., Bergsland, Emily, Jones, Suzanne, Martin, Thomas, Infante, Jeffrey R., Mischel, Paul S., Matsutani, Tomoo, Xu, Shuichan, Wong, Lilly, Liu, Yong, Wu, Xiaoling, Mortensen, Deborah S., Chopra, Rajesh, Hege, Kristen, Munster, Pamela N.
Published in Cancer (01.10.2015)
Published in Cancer (01.10.2015)
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Journal Article
Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005
Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Journal Article
Structure-based optimization of aminothiadiazole inhibitors of AKT
Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Genetic and pharmacologic evidence that mTOR targeting outweighs mTORC1 inhibition as an antimyeloma strategy
Chen, Xi, Díaz-Rodríguez, Elena, Ocio, Enrique M, Paiva, Bruno, Mortensen, Deborah S, Lopez-Girona, Antonia, Chopra, Rajesh, Miguel, Jesús San, Pandiella, Atanasio
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Journal Article
Synthesis and Biological Evaluation of a Novel Series of Furans: Ligands Selective for Estrogen Receptor α
Mortensen, Deborah S, Rodriguez, Alice L, Carlson, Kathryn E, Sun, Jun, Katzenellenbogen, Benita S, Katzenellenbogen, John A
Published in Journal of medicinal chemistry (08.11.2001)
Published in Journal of medicinal chemistry (08.11.2001)
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Journal Article
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha
Mortensen, Deborah S., Rodriguez, Alice L., Sun, Jun, Katzenellenbogen, Benita S., Katzenellenbogen, John A.
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
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A concise, stereoselective and scalable synthesis of optically pure (3R,4R)-1-benzyl- and (3R,4R)-1-Boc-3-methyl-4-aminopiperidines
Hazra, Sunit, Kangune, Ankit, Pawar, Govind, Karmakar, Ananta, Pabbisetty, Kumar B., Mortensen, Deborah S., Dodd, Dharmpal S., Li, Jianqing, Mathur, Arvind, Gupta, Anuradha, Nimje, Roshan Y.
Published in Tetrahedron (07.11.2024)
Published in Tetrahedron (07.11.2024)
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