Adjusting for common variant polygenic scores improves yield in rare variant association analyses
Jurgens, Sean J, Pirruccello, James P, Choi, Seung Hoan, Morrill, Valerie N, Chaffin, Mark, Lubitz, Steven A, Lunetta, Kathryn L, Ellinor, Patrick T
Published in Nature genetics (01.04.2023)
Published in Nature genetics (01.04.2023)
Get full text
Journal Article
Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Nauffal, Victor, Di Achille, Paolo, Klarqvist, Marcus D R, Cunningham, Jonathan W, Hill, Matthew C, Pirruccello, James P, Weng, Lu-Chen, Morrill, Valerie N, Choi, Seung Hoan, Khurshid, Shaan, Friedman, Samuel F, Nekoui, Mahan, Roselli, Carolina, Ng, Kenney, Philippakis, Anthony A, Batra, Puneet, Ellinor, Patrick T, Lubitz, Steven A
Published in Nature genetics (01.05.2023)
Published in Nature genetics (01.05.2023)
Get full text
Journal Article
LMNA Variants and Risk of Adult-Onset Cardiac Disease
Lazarte, Julieta, Jurgens, Sean J, Choi, Seung Hoan, Khurshid, Shaan, Morrill, Valerie N, Weng, Lu-Chen, Nauffal, Victor, Pirruccello, James P, Halford, Jennifer L, Hegele, Robert A, Ellinor, Patrick T, Lunetta, Kathryn L, Lubitz, Steven A
Published in Journal of the American College of Cardiology (05.07.2022)
Published in Journal of the American College of Cardiology (05.07.2022)
Get full text
Journal Article
Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank
Biddinger, Kiran J, Jurgens, Sean J, Maamari, Dimitri, Gaziano, Liam, Choi, Seung Hoan, Morrill, Valerie N, Halford, Jennifer L, Khera, Amit V, Lubitz, Steven A, Ellinor, Patrick T, Aragam, Krishna G
Published in JAMA cardiology (01.07.2022)
Published in JAMA cardiology (01.07.2022)
Get more information
Journal Article
Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder
Yao, Michael, Daniels, Jason, Grosvenor, Luke, Morrill, Valerie, Feinberg, Jason I, Bakulski, Kelly M, Piven, Joseph, Hazlett, Heather C, Shen, Mark D, Newschaffer, Craig, Lyall, Kristen, Schmidt, Rebecca J, Hertz-Picciotto, Irva, Croen, Lisa A, Fallin, M. Daniele, Ladd-Acosta, Christine, Volk, Heather, Benke, Kelly
Published in Journal of neurodevelopmental disorders (12.09.2024)
Published in Journal of neurodevelopmental disorders (12.09.2024)
Get full text
Journal Article
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch
Cunningham, Jonathan W, Di Achille, Paolo, Morrill, Valerie N, Weng, Lu-Chen, Choi, Seung Hoan, Khurshid, Shaan, Nauffal, Victor, Pirruccello, James P, Solomon, Scott D, Batra, Puneet, Ho, Jennifer E, Philippakis, Anthony A, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation. Genomic and precision medicine (01.02.2023)
Published in Circulation. Genomic and precision medicine (01.02.2023)
Get more information
Journal Article
Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank
Halford, Jennifer L, Weng, Lu-Chen, Choi, Seung Hoan, Jurgens, Sean J, Morrill, Valerie N, Khurshid, Shaan, Trinquart, Ludovic, Benjamin, Emelia J, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation. Genomic and precision medicine (01.12.2020)
Published in Circulation. Genomic and precision medicine (01.12.2020)
Get more information
Journal Article
Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis
Choi, Seung Hoan, Jurgens, Sean J, Haggerty, Christopher M, Hall, Amelia W, Halford, Jennifer L, Morrill, Valerie N, Weng, Lu-Chen, Lagerman, Braxton, Mirshahi, Tooraj, Pettinger, Mary, Guo, Xiuqing, Lin, Henry J, Alonso, Alvaro, Soliman, Elsayed Z, Kornej, Jelena, Lin, Honghuang, Moscati, Arden, Nadkarni, Girish N, Brody, Jennifer A, Wiggins, Kerri L, Cade, Brian E, Lee, Jiwon, Austin-Tse, Christina, Blackwell, Tom, Chaffin, Mark D, Lee, Christina J-Y, Rehm, Heidi L, Roselli, Carolina, Redline, Susan, Mitchell, Braxton D, Sotoodehnia, Nona, Psaty, Bruce M, Heckbert, Susan R, Loos, Ruth J F, Vasan, Ramachandran S, Benjamin, Emelia J, Correa, Adolfo, Boerwinkle, Eric, Arking, Dan E, Rotter, Jerome I, Rich, Stephen S, Whitsel, Eric A, Perez, Marco, Kooperberg, Charles, Fornwalt, Brandon K, Lunetta, Kathryn L, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation. Genomic and precision medicine (01.08.2021)
Published in Circulation. Genomic and precision medicine (01.08.2021)
Get more information
Journal Article
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Jurgens, Sean J, Choi, Seung Hoan, Morrill, Valerie N, Chaffin, Mark, Pirruccello, James P, Halford, Jennifer L, Weng, Lu-Chen, Nauffal, Victor, Roselli, Carolina, Hall, Amelia W, Oetjens, Matthew T, Lagerman, Braxton, vanMaanen, David P, Aragam, Krishna G, Lunetta, Kathryn L, Haggerty, Christopher M, Lubitz, Steven A, Ellinor, Patrick T
Published in Nature genetics (01.03.2022)
Published in Nature genetics (01.03.2022)
Get full text
Journal Article
Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content
Marston, Nicholas A, Giugliano, Robert P, Melloni, Giorgio E M, Park, Jeong-Gun, Morrill, Valerie, Blazing, Michael A, Ference, Brian, Stein, Evan, Stroes, Erik S, Braunwald, Eugene, Ellinor, Patrick T, Lubitz, Steven A, Ruff, Christian T, Sabatine, Marc S
Published in JAMA cardiology (01.03.2022)
Published in JAMA cardiology (01.03.2022)
Get more information
Journal Article
Abstract 13496: Sequencing in Over 50,000 Cases Identifies Coding and Structural Variation Underlying Atrial Fibrillation Risk
Jurgens, Sean J, Choi, Seung H, Haggerty, Christopher M, Xiao, Ling, Morrill, Valerie N, Marston, Nicholas A, Weng, Lu C, Pirruccello, James P, Hill, Matthew C, Ruff, Christian T, Sabatine, Marc S, Lunetta, Kathryn, Lubitz, Steven A, Ellinor, Patrick T
Published in Circulation (New York, N.Y.) (08.11.2022)
Published in Circulation (New York, N.Y.) (08.11.2022)
Get full text
Journal Article
Abstract 15005: Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank
Halford, Jennifer L, Weng, Lu Chen, Choi, Seung Hoan, Jurgens, Sean J, Morrill, Valerie, Khurshid, Shaan, Trinquart, Ludovic, Benjamin, Emelia J, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation (New York, N.Y.) (17.11.2020)
Published in Circulation (New York, N.Y.) (17.11.2020)
Get full text
Journal Article
Abstract 13271: Combined Assessments of Monogenic and Polygenic Risk for Dilated Cardiomyopathy
Aragam, Krishna G, Biddinger, Kiran, Jurgens, Sean J, Wang, Minxian, Pirruccello, James, Maamari, Dimitri, Chaffin, Mark, Choi, Seung H, Morrill, Valerie, Newton-cheh, Christopher, Khera, Amit V, Lubitz, Steven A, Ellinor, Patrick T
Published in Circulation (New York, N.Y.) (16.11.2021)
Published in Circulation (New York, N.Y.) (16.11.2021)
Get full text
Journal Article
Genetic liability for gastrointestinal inflammation disorders and association with gastrointestinal symptoms in children with and without autism
Morrill, Valerie, Benke, Kelly, Brinton, John, Soke, Gnakub N., Schieve, Laura A., Fields, Victoria, Farzadegan, Homayoon, Holingue, Calliope, Newschaffer, Craig J., Reynolds, Ann M., Fallin, M. Daniele, Ladd‐Acosta, Christine
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.01.2024)
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.01.2024)
Get full text
Journal Article
Abstract 10816: Causal Effect of Atrial Fibrillation on Cardiovascular Diseases - A Mendelian Randomization Analysis in the Million Veteran Program
Nauffal, Victor, Weng, Lu-Chen, Treu, Timothy, Gunn, Sophia, Morrill, Valerie N, Galloway, Ashley, Khurshid, Shaan, Ko, Darae, Logue, Mark W, Hauger, Richard L, Lunetta, Kathryn L, Joseph, Jacob, Sun, Yan, Benjamin, Emelia J, Gaziano, Michael, Cho, Kelly, Wilson, Peter, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation (New York, N.Y.) (16.11.2021)
Published in Circulation (New York, N.Y.) (16.11.2021)
Get full text
Journal Article
Monogenic and Polygenic Contributions to QTc Prolongation in the Population
Nauffal, Victor, Morrill, Valerie N, Jurgens, Sean J, Choi, Seung Hoan, Hall, Amelia W, Weng, Lu-Chen, Halford, Jennifer L, Austin-Tse, Christina, Haggerty, Christopher M, Harris, Stephanie L, Wong, Eugene K, Alonso, Alvaro, Arking, Dan E, Benjamin, Emelia J, Boerwinkle, Eric, Min, Yuan-I, Correa, Adolfo, Fornwalt, Brandon K, Heckbert, Susan R, Kooperberg, Charles, Lin, Henry J, J F Loos, Ruth, Rice, Kenneth M, Gupta, Namrata, Blackwell, Thomas W, Mitchell, Braxton D, Morrison, Alanna C, Psaty, Bruce M, Post, Wendy S, Redline, Susan, Rehm, Heidi L, Rich, Stephen S, Rotter, Jerome I, Soliman, Elsayed Z, Sotoodehnia, Nona, Lunetta, Kathryn L, Ellinor, Patrick T, Lubitz, Steven A
Published in Circulation (New York, N.Y.) (17.05.2022)
Published in Circulation (New York, N.Y.) (17.05.2022)
Get full text
Journal Article
B-YIA1-02 MONOGENIC AND POLYGENIC CONTRIBUTIONS TO QTC PROLONGATION IN THE POPULATION
Nauffal, Victor, Morrill, Valerie N., Jurgens, Sean S., Austin-Tse, Christina, Benjamin, Emelia J., Boerwinkle, Eric, Choi, Seung Hoan, Correa, Adolfo, Fornwalt, Brandon, Haggerty, Christopher, Halford, Jenifer, Hall, Amelia, Heckbert, Susan, Kooperberg, Charles, Lin, Henry, Loos, Ruth, Lunetta, Kathryn, Mitchell, Braxton, Morrison, Alanna, Post, Wendy, Psaty, Bruce, Redline, Susan, Rehm, Heidi, Rotter, Jerome, Soliman, Elsayed, Sotoodehnia, Nona, Weng, Lu-Chen, Ellinor, Patrick T., Lubitz, Steven A.
Published in Heart rhythm (01.08.2021)
Published in Heart rhythm (01.08.2021)
Get full text
Journal Article
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Jurgens, Sean J, Choi, Seung Hoan, Morrill, Valerie N, Chaffin, Mark, Pirruccello, James P, Halford, Jennifer L, Weng, Lu-Chen, Nauffal, Victor, Roselli, Carolina, Hall, Amelia W, Oetjens, Matthew T, Lagerman, Braxton, Vanmaanen, David P, Aragam, Krishna G, Lunetta, Kathryn L, Haggerty, Christopher M, Lubitz, Steven A, Ellinor, Patrick T, Abecasis, Goncalo, Bai, Xiaodong, Balasubramanian, Suganthi, Baras, Aris, Beechert, Christina, Boutkov, Boris, Cantor, Michael, Coppola, Giovanni, De, Tanima, Deubler, Andrew, Economides, Aris, Eom, Gisu, Ferreira, Manuel A R, sythe, Caitlin, Fuller, Erin D, Gu, Zhenhua, Habegger, Lukas, Hawes, Alicia, Jones, Marcus B, Karalis, Katia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Lattari, Michael, Li, Dadong, Lopez, Alexander, Lotta, Luca A, Manoochehri, Kia, Mansfield, Adam J, Maxwell, Evan K, Mighty, Jason, Mitnaul, Lyndon J, Nafde, Mona, Nielsen, Jonas, O'Keeffe, Sean, Orelus, Max, Overton, John D, Padilla, Maria Sotiropoulos, Panea, Razvan, Polanco, Tommy, Pradhan, Manasi, Rasool, Ayesha, Reid, Jeffrey G, Salerno, William, Schleicher, Thomas D, Shuldiner, Alan, Siminovitch, Katherine, Staples, Jeffrey C, Ulloa, Ricardo H, Verweij, Niek, Widom, Louis, Wolf, Sarah E
Published in Nature genetics (01.03.2022)
Published in Nature genetics (01.03.2022)
Get full text
Journal Article
Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes
Halford, Jennifer L, Morrill, Valerie N, Choi, Seung Hoan, Jurgens, Sean J, Melloni, Giorgio, Marston, Nicholas A, Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W, Gunn, Sophia, Austin-Tse, Christina A, Pirruccello, James P, Khurshid, Shaan, Rehm, Heidi L, Benjamin, Emelia J, Boerwinkle, Eric, Brody, Jennifer A, Correa, Adolfo, Fornwalt, Brandon K, Gupta, Namrata, Haggerty, Christopher M, Harris, Stephanie, Heckbert, Susan R, Hong, Charles C, Kooperberg, Charles, Lin, Henry J, Loos, Ruth J F, Mitchell, Braxton D, Morrison, Alanna C, Post, Wendy, Psaty, Bruce M, Redline, Susan, Rice, Kenneth M, Rich, Stephen S, Rotter, Jerome I, Schnatz, Peter F, Soliman, Elsayed Z, Sotoodehnia, Nona, Wong, Eugene K, Sabatine, Marc S, Ruff, Christian T, Lunetta, Kathryn L, Ellinor, Patrick T, Lubitz, Steven A
Published in Nature communications (30.08.2022)
Published in Nature communications (30.08.2022)
Get full text
Journal Article
Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes
Halford, Jennifer L, Morrill, Valerie N, Choi, Seung Hoan, Jurgens, Sean J, Melloni, Giorgio, Marston, Nicholas A, Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W, Gunn, Sophia, Austin-Tse, Christina A, Pirruccello, James P, Khurshid, Shaan, Rehm, Heidi L, Benjamin, Emelia J, Boerwinkle, Eric, Brody, Jennifer A, Correa, Adolfo, Fornwalt, Brandon K, Gupta, Namrata, Haggerty, Christopher M, Harris, Stephanie, Heckbert, Susan R, Hong, Charles C, Kooperberg, Charles, Lin, Henry J, Loos, Ruth J F, Mitchell, Braxton D, Morrison, Alanna C, Post, Wendy, Psaty, Bruce M, Redline, Susan, Rice, Kenneth M, Rich, Stephen S, Rotter, Jerome I, Schnatz, Peter F, Soliman, Elsayed Z, Sotoodehnia, Nona, Wong, Eugene K, Sabatine, Marc S, Ruff, Christian T, Lunetta, Kathryn L, Ellinor, Patrick T, Lubitz, Steven A
Published in Nature communications (30.09.2022)
Published in Nature communications (30.09.2022)
Get full text
Journal Article