DNA binding alters ARv7 dimer interactions
Özgün, Fatma, Kaya, Zeynep, Morova, Tunç, Geverts, Bart, Abraham, Tsion E, Houtsmuller, Adriaan B, van Royen, Martin E, Lack, Nathan A
Published in Journal of cell science (15.07.2021)
Published in Journal of cell science (15.07.2021)
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Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions
Joosten, Stacey E P, Gregoricchio, Sebastian, Stelloo, Suzan, Yapıcı, Elif, Huang, Chia-Chi Flora, Yavuz, Kerim, Donaldson Collier, Maria, Morova, Tunç, Altintaş, Umut Berkay, Kim, Yongsoo, Canisius, Sander, Moelans, Cathy B, van Diest, Paul J, Korkmaz, Gozde, Lack, Nathan A, Vermeulen, Michiel, Linn, Sabine C, Zwart, Wilbert
Published in Genome research (01.04.2024)
Published in Genome research (01.04.2024)
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Functional mapping of androgen receptor enhancer activity
Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y, Gleave, Martin E, Bergman, Andries M, Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A
Published in Genome Biology (11.05.2021)
Published in Genome Biology (11.05.2021)
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Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours
Dada, Sarah, Ellis, Samantha L S, Wood, Christi, Nohara, Lilian L, Dreier, Carola, Garcia, Nicolas H, Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G, Eyford, Brett A, Kari, Suresh, Garrovillas, Emmanuel, Caspani, Giorgia, Al Haddad, Eliana, Gray, Patrick W, Morova, Tunc, Lack, Nathan A, Andersen, Raymond J, Tjoelker, Larry, Jefferies, Wilfred A
Published in Frontiers in immunology (22.02.2023)
Published in Frontiers in immunology (22.02.2023)
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EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
Yedier-Bayram, Ozlem, Gokbayrak, Bengul, Kayabolen, Alisan, Aksu, Ali Cenk, Cavga, Ayse Derya, Cingöz, Ahmet, Kala, Ezgi Yagmur, Karabiyik, Goktug, Günsay, Rauf, Esin, Beril, Morova, Tunc, Uyulur, Fırat, Syed, Hamzah, Philpott, Martin, Cribbs, Adam P., Kung, Sonia H. Y., Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba
Published in Cell death & disease (16.08.2022)
Published in Cell death & disease (16.08.2022)
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Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours
Ellis, Samantha L. S., Dada, Sarah, Nohara, Lilian L., Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G., Eyford, Brett A., Morova, Tunc, Williams, David E., Cheng, Ping, Lack, Nathan A., Andersen, Raymond J., Jefferies, Wilfred A.
Published in Frontiers in pharmacology (10.08.2023)
Published in Frontiers in pharmacology (10.08.2023)
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Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Ozyerli-Goknar, Ezgi, Kala, Ezgi Yagmur, Aksu, Ali Cenk, Bulut, Ipek, Cingöz, Ahmet, Nizamuddin, Sheikh, Biniossek, Martin, Seker-Polat, Fidan, Morova, Tunc, Aztekin, Can, Kung, Sonia H. Y., Syed, Hamzah, Tuncbag, Nurcan, Gönen, Mehmet, Philpott, Martin, Cribbs, Adam P., Acilan, Ceyda, Lack, Nathan A., Onder, Tamer T., Timmers, H. T. Marc, Bagci-Onder, Tugba
Published in Cell communication and signaling (16.11.2023)
Published in Cell communication and signaling (16.11.2023)
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Sulfated levan from Halomonas smyrnensis as a bioactive, heparin-mimetic glycan for cardiac tissue engineering applications
Erginer, Merve, Akcay, Ayca, Coskunkan, Binnaz, Morova, Tunc, Rende, Deniz, Bucak, Seyda, Baysal, Nihat, Ozisik, Rahmi, Eroglu, Mehmet S., Agirbasli, Mehmet, Toksoy Oner, Ebru
Published in Carbohydrate polymers (20.09.2016)
Published in Carbohydrate polymers (20.09.2016)
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Androgen receptor-binding sites are highly mutated in prostate cancer
Morova, Tunç, McNeill, Daniel R., Lallous, Nada, Gönen, Mehmet, Dalal, Kush, Wilson, David M., Gürsoy, Attila, Keskin, Özlem, Lack, Nathan A.
Published in Nature communications (11.02.2020)
Published in Nature communications (11.02.2020)
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Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
Ebrahimi, Ayyub, Sevinç, Kenan, Gürhan Sevinç, Gülben, Cribbs, Adam P., Philpott, Martin, Uyulur, Fırat, Morova, Tunç, Dunford, James E., Göklemez, Sencer, Arı, Şule, Oppermann, Udo, Önder, Tamer T.
Published in Nature chemical biology (01.05.2019)
Published in Nature chemical biology (01.05.2019)
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Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer
Saraç, Hilal, Morova, Tunç, Pires, Elisabete, McCullagh, James, Kaplan, Anıl, Cingöz, Ahmet, Bagci-Onder, Tugba, Önder, Tamer, Kawamura, Akane, Lack, Nathan A.
Published in Oncogene (01.03.2020)
Published in Oncogene (01.03.2020)
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Journal Article
Androgen Receptor-Mediated Transcription in Prostate Cancer
Özturan, Doğancan, Morova, Tunç, Lack, Nathan A
Published in Cells (Basel, Switzerland) (05.03.2022)
Published in Cells (Basel, Switzerland) (05.03.2022)
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Journal Article
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A., Bergman, Andries M., Zwart, Wilbert
Published in Nature communications (30.11.2022)
Published in Nature communications (30.11.2022)
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Editorial Expression of Concern: Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization
Cingöz, Ahmet, Ozyerli-Goknar, Ezgi, Morova, Tunc, Seker-Polat, Fidan, Selvan, Myvizhi Esai, Gümüş, Zeynep Hülya, Bhere, Deepak, Shah, Khalid, Solaroglu, Ihsan, Bagci-Onder, Tugba
Published in Oncogene (01.08.2024)
Published in Oncogene (01.08.2024)
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Abstract 5208: Genome-wide AR enhancer activity in prostate cancer
Ozturan, Dogancan, Huang, Flora, Morova, Tunc, Saffarzadeh, Mohammadali, Lack, Nathan A.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization
Cingöz, Ahmet, Ozyerli-Goknar, Ezgi, Morova, Tunc, Seker-Polat, Fidan, Esai Selvan, Myvizhi, Gümüş, Zeynep Hülya, Bhere, Deepak, Shah, Khalid, Solaroglu, Ihsan, Bagci-Onder, Tugba
Published in Oncogene (06.05.2021)
Published in Oncogene (06.05.2021)
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Abstract 3412: Androgen receptor binding sites are highly mutated in prostate cancer
Morova, Tunc, Gonen, Mehmet, Gursoy, Attila, Keskin, Ozlem, Lack, Nathan A.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation
Baca, Sylvan C., Singler, Cassandra, Zacharia, Soumya, Seo, Ji-Heui, Morova, Tunc, Hach, Faraz, Ding, Yi, Schwarz, Tommer, Huang, Chia-Chi Flora, Anderson, Jacob, Fay, André P., Kalita, Cynthia, Groha, Stefan, Pomerantz, Mark M., Wang, Victoria, Linder, Simon, Sweeney, Christopher J., Zwart, Wilbert, Lack, Nathan A., Pasaniuc, Bogdan, Takeda, David Y., Gusev, Alexander, Freedman, Matthew L.
Published in Nature genetics (01.09.2022)
Published in Nature genetics (01.09.2022)
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Optimized high-throughput screening of non-coding variants identified from genome-wide association studies
Morova, Tunc, Ding, Yi, Huang, Chia-Chi F, Sar, Funda, Schwarz, Tommer, Giambartolomei, Claudia, Baca, Sylvan C, Grishin, Dennis, Hach, Faraz, Gusev, Alexander, Freedman, Matthew L, Pasaniuc, Bogdan, Lack, Nathan A
Published in Nucleic acids research (22.02.2023)
Published in Nucleic acids research (22.02.2023)
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Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Eickhoff, Nils, Schuurman, Karianne, de Barros, Hilda, Alkemade, Maartje, Bekers, Elise M, Severson, Tesa M, Sanders, Joyce, Huang, Chia-Chi Flora, Morova, Tunc, Altintas, Umut Berkay, Hoekman, Liesbeth, Kim, Yongsoo, Baca, Sylvan C, Sjöström, Martin, Zaalberg, Anniek, Hintzen, Dorine C, de Jong, Jeroen, Kluin, Roelof J C, de Rink, Iris, Giambartolomei, Claudia, Seo, Ji-Heui, Pasaniuc, Bogdan, Altelaar, Maarten, Medema, René H, Feng, Felix Y, Zoubeidi, Amina, Freedman, Matthew L, Wessels, Lodewyk F A, Butler, Lisa M, Lack, Nathan A, van der Poel, Henk, Bergman, Andries M, Zwart, Wilbert
Published in Cancer discovery (02.09.2022)
Published in Cancer discovery (02.09.2022)
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