Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation
Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.
Published in Cell reports (Cambridge) (08.01.2019)
Published in Cell reports (Cambridge) (08.01.2019)
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An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Targeting SH2 domains in breast cancer
Morlacchi, Pietro, Robertson, Fredika M, Klostergaard, Jim, McMurray, John S
Published in Future medicinal chemistry (01.01.2014)
Published in Future medicinal chemistry (01.01.2014)
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Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease
Knight, J. Morgan, Mandal, Pijus, Morlacchi, Pietro, Mak, Garbo, Li, Evan, Madison, Matthew, Landers, Cameron, Saxton, Brandon, Felix, Ed, Gilbert, Brian, Sederstrom, Joel, Varadhachary, Atul, Singh, Melissa M., Chatterjee, Dev, Corry, David B., McMurray, John S.
Published in The Journal of biological chemistry (29.06.2018)
Published in The Journal of biological chemistry (29.06.2018)
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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity
Mandal, Pijus K, Morlacchi, Pietro, Knight, J. Morgan, Link, Todd M, Lee, Gilbert R, Nurieva, Roza, Singh, Divyendu, Dhanik, Ankur, Kavraki, Lydia, Corry, David B, Ladbury, John E, McMurray, John S
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Abstract C033: Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Cheng, Caleb, Wisniewski, Jasmine P, Peters, Sydney, Hu, Jing, Mannan, Rahul, Jackson, Bailey, Pakkan, Rüya, Morlacchi, Pietro, Magnuson, Brian, He, Tongchen, Bhattacharyya, Rupam, Qiao, Yuanyuan, Lyssiotis, Costas A, Chinnaiyan, Arul M
Published in Cancer research (Chicago, Ill.) (15.09.2024)
Published in Cancer research (Chicago, Ill.) (15.09.2024)
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Abstract 2087: Targeting lipid metabolism in pancreatic cancer
Cheng, Caleb, Wisniewski, Jasmine P., Korkaya, Ahmet, Jackson, Bailey, Mannan, Rahul, Mahapatra, Somnath, Rossiter, Nicholas, Bhattacharyya, Rupam, Morlacchi, Pietro, Peters, Sydney, Qiao, Yuanyuan, Lyssiotis, Costas A., Chinnaiyan, Arul M.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1023: Functional genomics reveals dependency on 6-phosphogluconate dehydrogenase in OXPHOS-deficient tumors
Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher, Rogers, Norma, Edward, Chang, Geck Do, Mary, Jiang, Yongying, Morlacchi, Pietro, Muller, Florian, Mseeh, Faika, Czako, Barbara, Palmer, Wylie, Toniatti, Carlo, Jones, Philip, Draetta, Giulio, Heffernan, Timothy, Marszalek, Joseph
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities
Jones, Philip, Francesco, M Emilia Di, Molina, Jennifer M., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher A., Carroll, Christopher L., Feng, Ningping, Gay, Jason P., Do, Mary K. Geck, Greer, Jennifer M., Konopleva, Marina, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda G., Fnu, Sonal, Theroff, Jay P., Draetta, Giulio, Toniatti, Carlo, Marszalek, Joseph R.
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Molina, Jennifer, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Cross, Jason, Daver, Naval, Feng, Ningping, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Han, Jing, Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Konopleva, Marina, Liu, Gang, Ma, Helen, Matre, Polina, McAfoos, Timothy, Meric-Bernstam, Funda, Morlacchi, Pietro, Muller, Florian, Protopopova, Marina, Smith, Melinda, Sonal, Sonal, Sun, Yuting, Theroff, Jay, Viale, Andrea, Xu, Quanyun, Toniatti, Carlo, Draetta, Giulio, Jones, Philip, Francesco, M. Emilia Di, Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 335: Title: IACS-010759 is a novel clinical candidate that targets AML cells by inducing a metabolic catastrophe through inhibition of oxidative phosphorylation
Molina, Jennifer R., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Feng, Ningping, Gay, Jason, Geck Do, Mary, Greer, Jennifer, Huang, Sha, Jiang, Yongying, Konopleva, Marina, Matre, Polina, Han, Jing, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda, Gera, Sonal, Theroff, Jay, Xu, Quanyun, Velez, Juliana, Toniatti, Carlo, Heffernan, Timothy, Draetta, Giulio, Di Francesco, M. Emilia, Jones, Philip, Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract LB-A15: IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe
Molina, Jennifer R., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Alimova, Maria, Carroll, Christopher, Chang, Edward, Feng, Ningping, Gay, Jason, Geck Do, Mary, Greer, Jennifer, Huang, Sha, Jiang, Yongying, Konopleva, Marina, Matre, Polina, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda, Sonal, Sonal, Theroff, Jay, Xu, Quanyun, Draetta, Giulio, Jones, Philip, Toniatti, Carlo, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione
Molina, Jennifer, Morlacchi, Pietro, Silva, Leslie, Dennison, Jennifer, Mills, Gordon
Published in Cancer & metabolism (28.05.2014)
Published in Cancer & metabolism (28.05.2014)
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Journal Article
Long-Acting Beta Agonists Enhance Allergic Airway Disease
Knight, John M., Ph.D, Mak, Garbo, Shaw, Joanne, McDermott, Catherine, Roberts, Luz, You, Ran, Yuan, Xiaoyi, Millien, Valentine O, Qian, Yuping, Song, Li-Zhen, Frazier, Vincent, Kim, Choel, Kim, Jeong j, Bond, Richard, Luong, Amber U., MD PhD, Kheradmand, Farrah, MD, McMurray, John, Mandal, Pijus K, Morlacchi, Pietro, Milner, Joshua D., MD, Corry, David B., MD
Published in Journal of allergy and clinical immunology (01.02.2015)
Published in Journal of allergy and clinical immunology (01.02.2015)
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Journal Article
Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Cheng, Caleb, Hu, Jing, Mannan, Rahul, Bhattacharyya, Rupam, Rossiter, Nicholas J, Magnuson, Brian, Wisniewski, Jasmine P, Zheng, Yang, Xiao, Lanbo, Li, Chungen, Awad, Dominik, He, Tongchen, Bao, Yi, Zhang, Yuping, Cao, Xuhong, Wang, Zhen, Mehra, Rohit, Morlacchi, Pietro, Sahai, Vaibhav, di Magliano, Marina Pasca, Shah, Yatrik M, Ding, Ke, Qiao, Yuanyuan, Lyssiotis, Costas A, Chinnaiyan, Arul M
Published in bioRxiv : the preprint server for biology (20.03.2024)
Published in bioRxiv : the preprint server for biology (20.03.2024)
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