In vitro and in vivo activities of the diazabicyclooctane OP0595 against AmpC-derepressed Pseudomonas aeruginosa
Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Keiko, Takayama, Yoshihiro, Sakakibara, Shiro, Takata, Toshihiko, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi, Sakamaki, Yoshiaki, Tsujii, Nakako, Ida, Takashi
Published in Journal of antibiotics (01.03.2017)
Published in Journal of antibiotics (01.03.2017)
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Journal Article
OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam 'enhancer'
Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Mototsugu, Suzuki, Kenji, Watanabe, Takashi, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi, Sakamaki, Yoshiaki, Mitsuhashi, Nakako, Ida, Takashi, Livermore, David M
Published in Journal of antimicrobial chemotherapy (01.10.2015)
Published in Journal of antimicrobial chemotherapy (01.10.2015)
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Journal Article
X-ray crystallographic analysis of IMP-1 metallo-β-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors
Hiraiwa, Yukiko, Saito, Jun, Watanabe, Takashi, Yamada, Mototsugu, Morinaka, Akihiro, Fukushima, Takayoshi, Kudo, Toshiaki
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
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Journal Article
Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity
Takahashi, Yoshiaki, Umemura, Eijiro, Kobayashi, Yoshihiko, Murakami, Shoichi, Nawa, Toru, Morinaka, Akihiro, Miyake, Toshiaki, Shibasaki, Masakatsu
Published in Journal of antibiotics (01.02.2018)
Published in Journal of antibiotics (01.02.2018)
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Journal Article
Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595
Jin, Wanchun, Wachino, Jun-Ichi, Yamaguchi, Yoshihiro, Kimura, Kouji, Kumar, Anupriya, Yamada, Mototsugu, Morinaka, Akihiro, Sakamaki, Yoshiaki, Yonezawa, Minoru, Kurosaki, Hiromasa, Arakawa, Yoshichika
Published in Antimicrobial agents and chemotherapy (01.10.2017)
Published in Antimicrobial agents and chemotherapy (01.10.2017)
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Journal Article
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
Hiraiwa, Yukiko, Morinaka, Akihiro, Fukushima, Takayoshi, Kudo, Toshiaki
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
In Vitro and In Vivo Activities of OP0595, a New Diazabicyclooctane, against CTX-M-15-Positive Escherichia coli and KPC-Positive Klebsiella pneumoniae
Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Keiko, Takayama, Yoshihiro, Sakakibara, Shiro, Takata, Toshihiko, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi, Sakamaki, Yoshiaki, Tsujii, Nakako, Ida, Takashi
Published in Antimicrobial agents and chemotherapy (01.05.2016)
Published in Antimicrobial agents and chemotherapy (01.05.2016)
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Journal Article
Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes
Livermore, David M, Mushtaq, Shazad, Morinaka, Akihiro, Ida, Takashi, Maebashi, Kazunori, Hope, Russell
Published in Journal of antimicrobial chemotherapy (01.01.2013)
Published in Journal of antimicrobial chemotherapy (01.01.2013)
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Journal Article
OP0595, a new diazabicyclooctane: mode of action as a serine [Beta]-lactamase inhibitor, antibiotic and [Beta]-lactam 'enhancer'
Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Mototsugu, Suzuki, Kenji, Watanabe, Takashi, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi, Sakamaki, Yoshiaki, Mitsuhashi, Nakako, Ida, Takashi, Livermore, David M
Published in Journal of antimicrobial chemotherapy (01.10.2015)
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Published in Journal of antimicrobial chemotherapy (01.10.2015)
Journal Article
Metallo-b-lactamase inhibitory activity of phthalic acid derivatives
Hiraiwa, Yukiko, Morinaka, Akihiro, Fukushima, Takayoshi, Kudo, Toshiaki
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
NOVEL beta-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME
MORINAKA, AKIHIRO, FURUUCHI, TAKESHI, ABE, TAKAO, SAKAMAKI, YOSHIAKI, INAMURA, SEIICHI
Year of Publication 05.12.2013
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Year of Publication 05.12.2013
Patent
METALLO-β-LACTAMASE INHIBITOR
MORINAKA AKIHIRO, CHIKAUCHI KEN, ABE TAKAO, KUDO TOSHIAKI, IDA MIZUYO, HIRAIWA YUKIKO
Year of Publication 02.09.2015
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Year of Publication 02.09.2015
Patent
METALLO-β-LACTAMASE INHIBITOR
MORINAKA AKIHIRO, CHIKAUCHI KEN, ABE TAKAO, KUDO TOSHIAKI, IDA MIZUYO, HIRAIWA YUKIKO
Year of Publication 24.12.2014
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Year of Publication 24.12.2014
Patent
NDM INHIBITOR
MORINAKA AKIHIRO, HIKIDA MUNEO, IDA TAKASHI, ABE TAKAO, MAEBASHI KAZUNORI, YAMADA MOTOTSUGU
Year of Publication 31.01.2013
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Year of Publication 31.01.2013
Patent
PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND
FURUUCHI, Takeshi, SAKAMAKI, Yoshiaki, ABE, Takao, INAMURA, Seiichi, MORINAKA, Akihiro
Year of Publication 19.10.2023
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Year of Publication 19.10.2023
Patent