Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Romero, Donna L, Morge, Raymond A, Biles, Carolyn, Berrios-Pena, Norman, May, Paul D, Palmer, John R, Johnson, Paul D, Smith, Herman W, Busso, Mariano, et. al
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors
Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate (U-90152S), a second-generation clinical candidate
Romero, Donna L, Morge, Raymond A, Genin, Michael J, Biles, Carolyn, Busso, Mariano, Resnick, Lionel, Althaus, Irene W, Reusser, Fritz, Thomas, Richard C, Tarpley, William G
Published in Journal of medicinal chemistry (01.05.1993)
Published in Journal of medicinal chemistry (01.05.1993)
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BIS(HETEROARYL)PIPERAZINE (BHAP) REVERSE-TRANSCRIPTASE INHIBITORS - STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL SUBSTITUTED INDOLE ANALOGS AND THE IDENTIFICATION OF 1-[(5-METHANESULFONAMIDO-1H-INDOL-2-YL)-CARBONYL]-4-[3-[(1-METHYLETHYL)AMINO]-PYRIDINYL]PIPERAZINE MONOMETHANESULFONATE (U-90152S), A 2ND-GENERATION CLINICAL CANDIDATE
ROMERO, DL, MORGE, RA, GENIN, MJ, BILES, C, BUSSO, M, RESNICK, L, ALTHAUS, IW, REUSSER, F, THOMAS, RC, TARPLEY, WG
Published in Journal of medicinal chemistry (14.05.1993)
Published in Journal of medicinal chemistry (14.05.1993)
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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes
Olmsted, R A, Slade, D E, Kopta, L A, Poppe, S M, Poel, T J, Newport, S W, Rank, K B, Biles, C, Morge, R A, Dueweke, T J, Yagi, Y, Romero, D L, Thomas, R C, Sharma, S K, Tarpley, W G
Published in Journal of Virology (01.06.1996)
Published in Journal of Virology (01.06.1996)
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