M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
Morgan, Hugh P., O'Reilly, Francis J., Wear, Martin A., O'Neill, J. Robert, Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (09.04.2013)
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Journal Article
Structural basis for engagement by complement factor H of C3b on a self surface
Barlow, Paul N, Hannan, Jonathan P, Morgan, Hugh P, Schmidt, Christoph Q, Guariento, Mara, Blaum, Bärbel S, Gillespie, Dominic, Herbert, Andrew P, Kavanagh, David, Mertens, Haydyn D T, Svergun, Dmitri I, Johansson, Conny M, Uhrín, Dušan
Published in Nature structural & molecular biology (01.04.2011)
Published in Nature structural & molecular biology (01.04.2011)
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Journal Article
The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site
Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Zhong, Wenhe, Michels, Paul A.M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in The Journal of biological chemistry (09.09.2011)
Published in The Journal of biological chemistry (09.09.2011)
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Journal Article
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)
Morgan, Hugh P, Mertens, Haydyn D T, Guariento, Mara, Schmidt, Christoph Q, Soares, Dinesh C, Svergun, Dmitri I, Herbert, Andrew P, Barlow, Paul N, Hannan, Jonathan P
Published in PloS one (28.02.2012)
Published in PloS one (28.02.2012)
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Journal Article
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase
Morgan, Hugh P, Walsh, Martin J, Blackburn, Elizabeth A, Wear, Martin A, Boxer, Matthew B, Shen, Min, Veith, Henrike, McNae, Iain W, Nowicki, Matthew W, Michels, Paul A M, Auld, Douglas S, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D
Published in Biochemical journal (15.11.2012)
Published in Biochemical journal (15.11.2012)
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Journal Article
Pyruvate kinases have an intrinsic and conserved decarboxylase activity
Zhong, Wenhe, Morgan, Hugh P, Nowicki, Matthew W, McNae, Iain W, Yuan, Meng, Bella, Juraj, Michels, Paul A M, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D
Published in Biochemical journal (01.03.2014)
Published in Biochemical journal (01.03.2014)
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Journal Article
Crystal Structures of Leishmania mexicana Phosphoglycerate Mutase Suggest a One-Metal Mechanism and a New Enzyme Subclass
Nowicki, Matthew W., Kuaprasert, Buabarn, McNae, Iain W., Morgan, Hugh P., Harding, Marjorie M., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Journal of molecular biology (04.12.2009)
Published in Journal of molecular biology (04.12.2009)
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Journal Article
Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
Mitchell, Alice Rose, Yuan, Meng, Morgan, Hugh P, McNae, Iain W, Blackburn, Elizabeth A, Le Bihan, Thierry, Homem, Rafael A, Yu, Manda, Loake, Gary J, Michels, Paul A, Wear, Martin A, Walkinshaw, Malcolm D
Published in Biochemical journal (31.10.2018)
Published in Biochemical journal (31.10.2018)
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Journal Article
Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model
Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Hannaert, Véronique, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in The Journal of biological chemistry (23.04.2010)
Published in The Journal of biological chemistry (23.04.2010)
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Journal Article
Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion
Herbert, Andrew P, Kavanagh, David, Johansson, Conny, Morgan, Hugh P, Blaum, Bärbel S, Hannan, Jonathan P, Barlow, Paul N, Uhrín, Dušan
Published in Biochemistry (Easton) (06.03.2012)
Published in Biochemistry (Easton) (06.03.2012)
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Journal Article
Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states
Blackburn, Elizabeth A., Fuad, Fazia A.A., Morgan, Hugh P., Nowicki, Matthew W., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Biochemical and biophysical research communications (25.07.2014)
Published in Biochemical and biophysical research communications (25.07.2014)
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Journal Article
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase
Brimacombe, Kyle R, Walsh, Martin J, Liu, Li, Vásquez-Valdivieso, Montserrat G, Morgan, Hugh P, McNae, Iain, Fothergill-Gilmore, Linda A, Michels, Paul A. M, Auld, Douglas S, Simeonov, Anton, Walkinshaw, Malcolm D, Shen, Min, Boxer, Matthew B
Published in ACS medicinal chemistry letters (09.01.2014)
Published in ACS medicinal chemistry letters (09.01.2014)
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Journal Article
Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H
Morgan, Hugh P., Jiang, Jingzi, Herbert, Andrew P., Kavanagh, David, Uhrin, Dušan, Barlow, Paul N., Hannan, Jonathan P.
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2011)
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2011)
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Journal Article
Sulphate Removal Induces a Major Conformational Change in Leishmania mexicana Pyruvate Kinase in the Crystalline State
Tulloch, Lindsay B., Morgan, Hugh P., Hannaert, Véronique, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Journal of molecular biology (14.11.2008)
Published in Journal of molecular biology (14.11.2008)
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Journal Article
Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach
Morgan, Hugh P, Estibeiro, Peter, Wear, Martin A, Max, Klaas E.A, Heinemann, Udo, Cubeddu, Liza, Gallagher, Maurice P, Sadler, Peter J, Walkinshaw, Malcolm D
Published in Nucleic acids research (01.05.2007)
Published in Nucleic acids research (01.05.2007)
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Journal Article
Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo
Fuad, Fazia Adyani Ahmad, Fothergill-Gilmore, Linda A, Nowicki, Matthew W, Eades, Lorna J, Morgan, Hugh P, McNae, Iain W, Michels, Paul A M, Walkinshaw, Malcolm D
Published in Metallomics (01.12.2011)
Published in Metallomics (01.12.2011)
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Journal Article
In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase
Zhong, Wenhe, Morgan, Hugh P., McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2013)
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Journal Article
Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium
Morgan, Hugh P., Wear, Martin A., McNae, Iain, Gallagher, Maurice P., Walkinshaw, Malcolm D.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.12.2009)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.12.2009)
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Journal Article