The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
Pitman, Melissa R., Lewis, Alexander C., Davies, Lorena T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Powell, Jason A., Pitson, Stuart M.
Published in Scientific reports (10.01.2022)
Published in Scientific reports (10.01.2022)
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia
Powell, Jason A., Lewis, Alexander C., Zhu, Wenying, Toubia, John, Pitman, Melissa R., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Iarossi, Diana, Samaraweera, Saumya E., Cummings, Nik, Ramshaw, Hayley S., Thomas, Daniel, Wei, Andrew H., Lopez, Angel F., D'Andrea, Richard J., Lewis, Ian D., Pitson, Stuart M.
Published in Blood (09.02.2017)
Published in Blood (09.02.2017)
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Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma
Neubauer, Heidi A., Tea, Melinda N., Zebol, Julia R., Gliddon, Briony L., Stefanidis, Cassandra, Moretti, Paul A. B., Pitman, Melissa R., Costabile, Maurizio, Kular, Jasreen, Stringer, Brett W., Day, Bryan W., Samuel, Michael S., Bonder, Claudine S., Powell, Jason A., Pitson, Stuart M.
Published in Oncogene (01.02.2019)
Published in Oncogene (01.02.2019)
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The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane
Sutherland, Catherine M., Moretti, Paul A.B., Hewitt, Niamh M., Bagley, Christopher J., Vadas, Mathew A., Pitson, Stuart M.
Published in The Journal of biological chemistry (28.04.2006)
Published in The Journal of biological chemistry (28.04.2006)
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CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1
Zhu, Wenying, Jarman, Kate E, Lokman, Noor A, Neubauer, Heidi A, Davies, Lorena T, Gliddon, Briony L, Taing, Houng, Moretti, Paul A B, Oehler, Martin K, Pitman, Melissa R, Pitson, Stuart M
Published in Cancer research (Chicago, Ill.) (15.09.2017)
Published in Cancer research (Chicago, Ill.) (15.09.2017)
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Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A
Barr, Renae K., Lynn, Helen E., Moretti, Paul A.B., Khew-Goodall, Yeesim, Pitson, Stuart M.
Published in The Journal of biological chemistry (12.12.2008)
Published in The Journal of biological chemistry (12.12.2008)
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Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia
Lewis, Alexander C., Pope, Victoria S., Tea, Melinda N., Li, Manjun, Nwosu, Gus O., Nguyen, Thao M., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Anderson, Dovile, Creek, Darren J., Costabile, Maurizio, Ali, Saira R., Thompson-Peach, Chloe A.L., Dredge, B. Kate, Bert, Andrew G., Goodall, Gregory J., Ekert, Paul G., Brown, Anna L., D'Andrea, Richard, Robinson, Nirmal, Pitman, Melissa R., Thomas, Daniel, Ross, David M., Gliddon, Briony L., Powell, Jason A., Pitson, Stuart M.
Published in Blood (30.06.2022)
Published in Blood (30.06.2022)
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Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody
Tvorogov, Denis, Thompson‐Peach, Chloe A L, Foßelteder, Johannes, Dottore, Mara, Stomski, Frank, Onnesha, Suraiya A, Lim, Kelly, Moretti, Paul A B, Pitson, Stuart M, Ross, David M, Reinisch, Andreas, Thomas, Daniel, Lopez, Angel F
Published in EMBO reports (05.04.2022)
Published in EMBO reports (05.04.2022)
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Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress
Wallington-Beddoe, Craig T, Bennett, Melissa K, Vandyke, Kate, Davies, Lorena, Zebol, Julia R, Moretti, Paul A B, Pitman, Melissa R, Hewett, Duncan R, Zannettino, Andrew C W, Pitson, Stuart M
Published in Oncotarget (04.07.2017)
Published in Oncotarget (04.07.2017)
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An oncogenic role for sphingosine kinase 2
Neubauer, Heidi A, Pham, Duyen H, Zebol, Julia R, Moretti, Paul A B, Peterson, Amanda L, Leclercq, Tamara M, Chan, Huasheng, Powell, Jason A, Pitman, Melissa R, Samuel, Michael S, Bonder, Claudine S, Creek, Darren J, Gliddon, Briony L, Pitson, Stuart M
Published in Oncotarget (04.10.2016)
Published in Oncotarget (04.10.2016)
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A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties
Pitman, Melissa R, Powell, Jason A, Coolen, Carl, Moretti, Paul A B, Zebol, Julia R, Pham, Duyen H, Finnie, John W, Don, Anthony S, Ebert, Lisa M, Bonder, Claudine S, Gliddon, Briony L, Pitson, Stuart M
Published in Oncotarget (30.03.2015)
Published in Oncotarget (30.03.2015)
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A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1
Pitman, Melissa R., Barr, Renae K., Gliddon, Briony L., Magarey, Angus M., Moretti, Paul A.B., Pitson, Stuart M.
Published in The international journal of biochemistry & cell biology (01.03.2011)
Published in The international journal of biochemistry & cell biology (01.03.2011)
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The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1
Zebol, Julia R., Hewitt, Niamh M., Moretti, Paul A.B., Lynn, Helen E., Lake, Julie A., Li, Peng, Vadas, Mathew A., Wattenberg, Binks W., Pitson, Stuart M.
Published in The international journal of biochemistry & cell biology (01.04.2009)
Published in The international journal of biochemistry & cell biology (01.04.2009)
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The Nucleotide-binding Site of Human Sphingosine Kinase 1
Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Zareie, Reza, Derian, Claudia K., Darrow, Andrew L., Qi, Jenson, D'Andrea, Richard J., Bagley, Christopher J., Vadas, Mathew A., Wattenberg, Binks W.
Published in The Journal of biological chemistry (20.12.2002)
Published in The Journal of biological chemistry (20.12.2002)
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Journal Article
Over-Expression of Sphingosine Kinase-1 Enhances a Progenitor Phenotype in Human Endothelial Cells
BARRETT, JEFFREY M., PARHAM, KATE A., PIPPAL, JYOTSNA B., COCKSHELL, MICHAELIA P., MORETTI, PAUL A. B., BRICE, SARAH L., PITSON, STUART M., BONDER, CLAUDINE S.
Published in Microcirculation (New York, N.Y. 1994) (01.10.2011)
Published in Microcirculation (New York, N.Y. 1994) (01.10.2011)
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CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1
Zhu, W, Gliddon, B L, Jarman, K E, Moretti, P A B, Tin, T, Parise, L V, Woodcock, J M, Powell, J A, Ruszkiewicz, A, Pitman, M R, Pitson, S M
Published in Oncogene (04.05.2017)
Published in Oncogene (04.05.2017)
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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
Pitson, Stuart M, Moretti, Paul A.B, Zebol, Julia R, Lynn, Helen E, Xia, Pu, Vadas, Mathew A, Wattenberg, Binks W
Published in The EMBO journal (15.10.2003)
Published in The EMBO journal (15.10.2003)
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