Optimization of the Pharmacophore Model for 5-HT7R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives
López-Rodríguez, María L, Porras, Esther, Morcillo, M. José, Benhamú, Bellinda, Soto, Luis J, Lavandera, José L, Ramos, José A, Olivella, Mireia, Campillo, Mercedes, Pardo, Leonardo
Published in Journal of medicinal chemistry (18.12.2003)
Published in Journal of medicinal chemistry (18.12.2003)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT1A/α1-Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Ligand Recognition
López-Rodríguez, María L, Morcillo, M. José, Fernández, Esther, Rosado, M. Luisa, Pardo, Leonardo, Schaper, Klaus-Jürgen
Published in Journal of medicinal chemistry (18.01.2001)
Published in Journal of medicinal chemistry (18.01.2001)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 5. Study of the Physicochemical Influence of the Pharmacophore on 5-HT1A/α1-Adrenergic Receptor Affinity: Synthesis of a New Derivative with Mixed 5-HT1A/D2 Antagonist Properties
López-Rodríguez, María L, Morcillo, M. José, Fernández, Esther, Porras, Esther, Orensanz, Luis, Beneytez, Ma Eugenia, Manzanares, Jorge, Fuentes, Jose Angel
Published in Journal of medicinal chemistry (18.01.2001)
Published in Journal of medicinal chemistry (18.01.2001)
Get full text
Journal Article
Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor
López-Rodríguez, María L, Vicente, Bruno, Deupi, Xavier, Barrondo, Sergio, Olivella, Mireia, Morcillo, M José, Behamú, Bellinda, Ballesteros, Juan A, Sallés, Joan, Pardo, Leonardo
Published in Molecular pharmacology (01.07.2002)
Published in Molecular pharmacology (01.07.2002)
Get full text
Journal Article
Design, Synthesis and Pharmacological Evaluation of 5-Hydroxytryptamine1a Receptor Ligands to Explore the Three-Dimensional Structure of the Receptor
MarıÌa L. López-RodrıÌguez, Bruno Vicente, Xavier Deupi, Sergio Barrondo, Mireia Olivella, M. José Morcillo, Bellinda Behamú, Juan A. Ballesteros, Joan Sallés, Leonardo Pardo
Published in Molecular pharmacology (01.07.2002)
Published in Molecular pharmacology (01.07.2002)
Get full text
Journal Article
Synthesis, Structure and Cytostatic Activity of a Series of N-Substituted 3, 4-Diphenyl-1H-pyrrole-2, 5-diones
BRANA, Miguel Fernandez, FERNANDEZ, Ascension, GARRIDO, Mercedes, RODRIGUEZ, Maria Luz Lopez, MORCILLO, M. Jose, SANZ, Antonio M.
Published in Chemical & pharmaceutical bulletin (01.10.1989)
Published in Chemical & pharmaceutical bulletin (01.10.1989)
Get full text
Journal Article
First pharmacophoric hypothesis for 5-HT7 antagonism
López-Rodríguez, M L, Porras, E, Benhamú, B, Ramos, J A, Morcillo, M J, Lavandera, J L
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
Get full text
Journal Article
Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands
LOPEZ-RODRIGUEZ, Maria L, BENHAMU, Bellinda, MORCILLO, Ma José, TEJADA, Ignacio, AVILA, David, MARCO, Isabel, SCHIAPPARELLI, Lucio, FRECHILLA, Diana, DEL RIO, Joaquin
Published in Bioorganic & medicinal chemistry (01.10.2004)
Published in Bioorganic & medicinal chemistry (01.10.2004)
Get full text
Journal Article
Benzimidazole Derivatives. 2. Synthesis and Structure−Activity Relationships of New Azabicyclic Benzimidazole-4-carboxylic Acid Derivatives with Affinity for Serotoninergic 5-HT3 Receptors
López-Rodríguez, María L, Benhamú, Bellinda, Morcillo, M. José, Tejada, Ignacio D, Orensanz, Luis, Alfaro, M. José, Martín, M. Isabel
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 4. 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity
López-Rodríguez, María L, Morcillo, M. José, Rovat, Tandú K, Fernández, Esther, Vicente, Bruno, Sanz, Antonio M, Hernández, Medardo, Orensanz, Luis
Published in Journal of medicinal chemistry (14.01.1999)
Published in Journal of medicinal chemistry (14.01.1999)
Get full text
Journal Article
Optimization of the Pharmacophore Model for 5-HT 7 R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives
López-Rodríguez, María L., Porras, Esther, Morcillo, M. José, Benhamú, Bellinda, Soto, Luis J., Lavandera, José L., Ramos, José A., Olivella, Mireia, Campillo, Mercedes, Pardo, Leonardo
Published in Journal of medicinal chemistry (01.12.2003)
Published in Journal of medicinal chemistry (01.12.2003)
Get full text
Journal Article
Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands
López-Rodrı́guez, Marı́a L., Benhamú, Bellinda, Morcillo, Mª José, Tejada, Ignacio, Avila, David, Marco, Isabel, Schiapparelli, Lucio, Frechilla, Diana, Rı́o, Joaquı́n Del
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Get full text
Journal Article
Stereospecificity in the Reaction of Tetrahydro-.beta.-carboline-3-carboxylic Acids with Isocyanates and Isothiocyanates. Kinetic vs Thermodynamic Control
Lopez-Rodriguez, Maria L, Morcillo, M. Jose, Garrido, Mercedes, Benhamu, Bellinda, Perez, Virginia, de la Campa, Jose G
Published in Journal of organic chemistry (01.03.1994)
Published in Journal of organic chemistry (01.03.1994)
Get full text
Journal Article
Design, Synthesis and Pharmacological Evaluation of 5-Hydroxytryptamine 1a Receptor Ligands to Explore the Three-Dimensional Structure of the Receptor
López-Rodrı́guez, Marı́a L., Vicente, Bruno, Deupi, Xavier, Barrondo, Sergio, Olivella, Mireia, Morcillo, M. José, Behamú, Bellinda, Ballesteros, Juan A., Sallés, Joan, Pardo, Leonardo
Published in Molecular pharmacology (01.07.2002)
Published in Molecular pharmacology (01.07.2002)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT 1A /α 1 -Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Ligand Recognition
López-Rodríguez, María L., Morcillo, M. José, Fernández, Esther, Rosado, M. Luisa, Pardo, Leonardo, Schaper, Klaus-Jürgen
Published in Journal of medicinal chemistry (01.01.2001)
Published in Journal of medicinal chemistry (01.01.2001)
Get full text
Journal Article
Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists
López-Rodrı́guez, Marı́a L., Benhamú, Bellinda, Viso, Alma, Morcillo, M.José, Murcia, Marta, Orensanz, Luis, Alfaro, M.José, Martı́n, M.Isabel
Published in Bioorganic & medicinal chemistry (01.11.1999)
Published in Bioorganic & medicinal chemistry (01.11.1999)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity
López-Rodríguez, María L, Morcillo, M. José, Fernández, Esther, Porras, Esther, Murcia, Marta, Sanz, Antonio M, Orensanz, Luis
Published in Journal of medicinal chemistry (01.08.1997)
Published in Journal of medicinal chemistry (01.08.1997)
Get full text
Journal Article
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 5. Study of the Physicochemical Influence of the Pharmacophore on 5-HT 1A /α 1 -Adrenergic Receptor Affinity: Synthesis of a New Derivative with Mixed 5-HT 1A /D 2 Antagonist Properties
López-Rodríguez, María L., Morcillo, M. José, Fernández, Esther, Porras, Esther, Orensanz, Luis, Beneytez, M Eugenia, Manzanares, Jorge, Fuentes, Jose Angel
Published in Journal of medicinal chemistry (01.01.2001)
Published in Journal of medicinal chemistry (01.01.2001)
Get full text
Journal Article
Benzimidazole Derivatives. 2. Synthesis and Structure−Activity Relationships of New Azabicyclic Benzimidazole-4-carboxylic Acid Derivatives with Affinity for Serotoninergic 5-HT 3 Receptors
López-Rodríguez, María L., Benhamú, Bellinda, Morcillo, M. José, Tejada, Ignacio D., Orensanz, Luis, Alfaro, M. José, Martín, M. Isabel
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
Get full text
Journal Article