A Common Mechanism of Inhibition of the Mycobacterium tuberculosis Mycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone
Grzegorzewicz, Anna E., Korduláková, Jana, Jones, Victoria, Born, Sarah E.M., Belardinelli, Juan M., Vaquié, Adrien, Gundi, Vijay A. K.B., Madacki, Jan, Slama, Nawel, Laval, Françoise, Vaubourgeix, Julien, Crew, Rebecca M., Gicquel, Brigitte, Daffé, Mamadou, Morbidoni, Hector R., Brennan, Patrick J., Quémard, Annaik, McNeil, Michael R., Jackson, Mary
Published in The Journal of biological chemistry (09.11.2012)
Published in The Journal of biological chemistry (09.11.2012)
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Induction of a Novel Class of Diacylglycerol Acyltransferases and Triacylglycerol Accumulation in Mycobacterium tuberculosis as It Goes into a Dormancy-Like State in Culture
DANIEL, Jaiyanth, DEB, Chirajyoti, DUBEY, Vinod S, SIRAKOVA, Tatiana D, ABOMOELAK, Bassam, MORBIDONI, Hector R, KOLATTUKUDY, Pappachan E
Published in Journal of Bacteriology (01.08.2004)
Published in Journal of Bacteriology (01.08.2004)
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Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents
Fernández de Luco, Julia, Recio-Balsells, Alejandro I, Ghiano, Diego G, Bortolotti, Ana, Belardinelli, Juán Manuel, Liu, Nina, Hoffmann, Pascal, Lherbet, Christian, Tonge, Peter J, Tekwani, Babu, Morbidoni, Héctor R, Labadie, Guillermo R
Published in MedChemComm (01.01.2021)
Published in MedChemComm (01.01.2021)
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Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis
Vilchèze, Catherine, Morbidoni, Hector R., Weisbrod, Torin R., Iwamoto, Hiroyuki, Kuo, Mack, Sacchettini, James C., Jacobs, William R.
Published in Journal of Bacteriology (01.07.2000)
Published in Journal of Bacteriology (01.07.2000)
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Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, Marina A., Klepp, Laura I., Gioffré, Andrea, Sabio y García, Julia, Morbidoni, Hector R., Santangelo, María de la Paz, Cataldi, Angel A., Bigi, Fabiana
Published in Virulence (01.01.2013)
Published in Virulence (01.01.2013)
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New one-pot synthesis of anti-tuberculosis compounds inspired on isoniazid
Ghiano, Diego G., Recio-Balsells, Alejandro, Bortolotti, Ana, Defelipe, Lucas A., Turjanski, Adrián, Morbidoni, Héctor R., Labadie, Guillermo R.
Published in European journal of medicinal chemistry (15.12.2020)
Published in European journal of medicinal chemistry (15.12.2020)
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Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria
Kremer, Laurent, Dover, Lynn G., Morbidoni, Hector R., Vilchèze, Catherine, Maughan, William N., Baulard, Alain, Tu, Shiao-Chun, Honoré, Nadine, Deretic, Vojo, Sacchettini, James C., Locht, Camille, Jacobs, William, R., Besra, Gurdyal S.
Published in The Journal of biological chemistry (06.06.2003)
Published in The Journal of biological chemistry (06.06.2003)
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Deletion of MSMEG_1350 in Mycobacterium smegmatis causes loss of epoxy-mycolic acids, fitness alteration at low temperature and resistance to a set of mycobacteriophages
Di Capua, Cecilia B, Belardinelli, Juan M, Buchieri, María V, Bortolotti, Ana, Franceschelli, Jorgelina J, Morbidoni, Héctor R
Published in Microbiology (Society for General Microbiology) (01.12.2018)
Published in Microbiology (Society for General Microbiology) (01.12.2018)
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Bioinformatic Analysis of a Set of 14 Temperate Bacteriophages Isolated from Staphylococcus aureus Strains Highlights Their Massive Genetic Diversity
Suárez, Cristian A., Carrasco, Soledad T., Brandolisio, Facundo N. A., Abatangelo, Virginia, Boncompain, Carina A., Peresutti-Bacci, Natalia, Morbidoni, Héctor R.
Published in Microbiology spectrum (31.08.2022)
Published in Microbiology spectrum (31.08.2022)
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Journal Article
Impact of the deletion of the six mce operons in Mycobacterium smegmatis
Klepp, Laura I., Forrellad, Marina A., Osella, Ana V., Blanco, Federico C., Stella, Emma J., Bianco, María Verónica, Santangelo, María de la Paz, Sassetti, Cristopher, Jackson, Mary, Cataldi, Angel A., Bigi, Fabiana, Morbidoni, Héctor R.
Published in Microbes and infection (01.07.2012)
Published in Microbes and infection (01.07.2012)
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Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: Identification of the first inhibitor with anti-mycobacterial activity
Buchieri, María V., Riafrecha, Leonardo E., Rodríguez, Oscar M., Vullo, Daniela, Morbidoni, Héctor R., Supuran, Claudiu T., Colinas, Pedro A.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Targeting tuberculosis through a small focused library of 1,2,3-triazoles
Labadie, Guillermo R., de la Iglesia, Agustina, Morbidoni, Héctor R.
Published in Molecular diversity (01.11.2011)
Published in Molecular diversity (01.11.2011)
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A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide
Franceschelli, Jorgelina J., Belardinelli, Juan M., Tong, Ping, Loftus, Brendan, Recio-Balsells, Alejandro, Labadié, Guillermo R., Gordon, Stephen V., Morbidoni, Hector R.
Published in Tuberculosis (Edinburgh, Scotland) (01.09.2018)
Published in Tuberculosis (Edinburgh, Scotland) (01.09.2018)
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Journal Article
Unveiling the Biosynthetic Pathway for Short Mycolic Acids in Nontuberculous Mycobacteria: Mycobacterium smegmatis MSMEG_4301 and Its Ortholog Mycobacterium abscessus MAB_1915 Are Essential for the Synthesis of α′-Mycolic Acids
Di Capua, Cecilia B., Belardinelli, Juan M., Carignano, Hugo A., Buchieri, María V., Suarez, Cristian A., Morbidoni, Héctor R.
Published in Microbiology spectrum (31.08.2022)
Published in Microbiology spectrum (31.08.2022)
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Journal Article
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria
Kurth, Daniel G, Gago, Gabriela M, de la Iglesia, Agustina, Bazet Lyonnet, Bernardo, Lin, Ting-Wan, Morbidoni, Hector R, Tsai, Shiou-Chuan, Gramajo, Hugo
Published in Microbiology (Society for General Microbiology) (01.08.2009)
Published in Microbiology (Society for General Microbiology) (01.08.2009)
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