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Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer
Presa, Daniela, Khurram, Syed A., Zubir, Amir Z. A., Smarakan, Sneha, Cooper, Patricia A., Morais, Goreti R., Sadiq, Maria, Sutherland, Mark, Loadman, Paul M., McCaul, James, Shnyder, Steven D., Patterson, Laurence H., Pors, Klaus
Published in Scientific reports (23.09.2021)
Published in Scientific reports (23.09.2021)
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Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds
Ortuzar, Natalia, Karu, Kersti, Presa, Daniela, Morais, Goreti R., Sheldrake, Helen M., Shnyder, Steve D., Barnieh, Francis M., Loadman, Paul M., Patterson, Laurence H., Pors, Klaus, Searcey, Mark
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones
Errington, Rachel J., Sadiq, Maria, Cosentino, Laura, Wiltshire, Marie, Sadiq, Omair, Sini, Marcella, Lizano, Enric, Pujol, Maria D., Morais, Goreti R., Pors, Klaus
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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Abstract 4470: Development of a nanoparticle formulation of an MMP-activated, tumor-specific prodrug with an enhanced therapeutic index for the treatment of breast cancer
Khatoon, Zubeda, Spencer, Hannah L., Jones, Huw S., Morais, Goreti R., Estrada, Amalia R., Falconer, Robert A.
Published in Cancer research (Chicago, Ill.) (21.04.2025)
Published in Cancer research (Chicago, Ill.) (21.04.2025)
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Abstract 2683: Investigation to explore how duocarmycin prodrugs bioactivated by cytochrome P450 enzymes can be used in combination therapy to treat breast cancer cells
Denasio, Enrica, Shnyder, Steven D., Morais, Goreti R., Martin, Stewart G., Pors, Klaus
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 1074: Cellular uptake and metabolism of MT1-MMP-activated taxane prodrugs
Polykandritou, Athina, Serre, Alexandra, Spencer, Hannah, Morais, Goreti R., Race, Amanda, Shnyder, Steven, Loadman, Paul, Falconer, Robert A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 5669: Design and synthesis of membrane type matrix metalloproteinase (MT-MMP) targeted anti-tumor agents
Falconer, Robert A., Youssef, Ahmed M., Gimenez Warren, Javier, Morais, Goreti R., Mitchell, Andrew, Shnyder, Steve D., Gill, Jason H., Patterson, Laurence H., Loadman, Paul M.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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