PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Wang, Huibing, Meng, Huyan, Li, Xingyan, Zhu, Kezhou, Dong, Kangyun, Mookhtiar, Adnan K., Wei, Huiting, Li, Ying, Sun, Shao-Cong, Yuan, Junying
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
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Journal Article
PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes
Hamard, Pierre-Jacques, Santiago, Gabriel E., Liu, Fan, Karl, Daniel L., Martinez, Concepcion, Man, Na, Mookhtiar, Adnan K., Duffort, Stephanie, Greenblatt, Sarah, Verdun, Ramiro E., Nimer, Stephen D.
Published in Cell reports (Cambridge) (04.09.2018)
Published in Cell reports (Cambridge) (04.09.2018)
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Journal Article
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
Najafov, Ayaz, Luu, Hoang Son, Mookhtiar, Adnan K., Mifflin, Lauren, Xia, Hong-guang, Amin, Palak P., Ordureau, Alban, Wang, Huibing, Yuan, Junying
Published in Molecular cell (21.01.2021)
Published in Molecular cell (21.01.2021)
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Journal Article
BRAF and AXL oncogenes drive RIPK3 expression loss in cancer
Najafov, Ayaz, Zervantonakis, Ioannis K, Mookhtiar, Adnan K, Greninger, Patricia, March, Ryan J, Egan, Regina K, Luu, Hoang Son, Stover, Daniel G, Matulonis, Ursula A, Benes, Cyril H, Yuan, Junying
Published in PLoS biology (29.08.2018)
Published in PLoS biology (29.08.2018)
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Journal Article
Drug Repositioning in Glioblastoma: A Pathway Perspective
Tan, Sze Kiat, Jermakowicz, Anna, Mookhtiar, Adnan K, Nemeroff, Charles B, Schürer, Stephan C, Ayad, Nagi G
Published in Frontiers in pharmacology (16.03.2018)
Published in Frontiers in pharmacology (16.03.2018)
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Journal Article
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression
Mas, Gloria, Man, Na, Nakata, Yuichiro, Martinez-Caja, Concepcion, Karl, Daniel, Beckedorff, Felipe, Tamiro, Francesco, Chen, Chuan, Duffort, Stephanie, Itonaga, Hidehiro, Mookhtiar, Adnan K, Kunkalla, Kranthi, Valencia, Alfredo M, Collings, Clayton K, Kadoch, Cigall, Vega, Francisco, Kogan, Scott C, Shiekhattar, Ramin, Morey, Lluis, Bilbao, Daniel, Nimer, Stephen D
Published in The Journal of clinical investigation (03.07.2023)
Published in The Journal of clinical investigation (03.07.2023)
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Journal Article
Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity
Itonaga, Hidehiro, Mookhtiar, Adnan K, Greenblatt, Sarah M, Liu, Fan, Martinez, Concepcion, Bilbao, Daniel, Rains, Masai, Hamard, Pierre-Jacques, Sun, Jun, Umeano, Afoma C, Duffort, Stephanie, Chen, Chuan, Man, Na, Mas, Gloria, Tottone, Luca, Totiger, Tulasigeri, Bradley, Terrence, Taylor, Justin, Schürer, Stephan, Nimer, Stephen D
Published in Nature communications (22.04.2024)
Published in Nature communications (22.04.2024)
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Journal Article
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL
Najafov, Ayaz, Mookhtiar, Adnan K., Luu, Hoang Son, Ordureau, Alban, Pan, Heling, Amin, Palak P., Li, Ying, Lu, Qingxian, Yuan, Junying
Published in Molecular cell (08.08.2019)
Published in Molecular cell (08.08.2019)
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Journal Article
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
Dziedzic, Slawomir A, Su, Zhenyi, Jean Barrett, Vica, Najafov, Ayaz, Mookhtiar, Adnan K, Amin, Palak, Pan, Heling, Sun, Li, Zhu, Hong, Ma, Averil, Abbott, Derek W, Yuan, Junying
Published in Nature cell biology (01.01.2018)
Published in Nature cell biology (01.01.2018)
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Journal Article
PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2
Liu, Fan, Xu, Ye, Lu, Xiaoqing, Hamard, Pierre-Jacques, Karl, Daniel L, Man, Na, Mookhtiar, Adnan K, Martinez, Concepcion, Lossos, Izidore S, Sun, Jun, Nimer, Stephen D
Published in Nucleic acids research (06.04.2020)
Published in Nucleic acids research (06.04.2020)
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Journal Article
Arginine Methylation of BRD4 By CARM1 Regulates Its Function in AML
Mookhtiar, Adnan K., Itonaga, Hidehiro, Greenblatt, Sarah, Martinez, Concepcion, Sun, Jun, Hossack, Krystal Lisa, Shiekhattar, Ramin, Bilbao, Daniel, Figueroa, Maria Ken E., Sidoli, Simone, Nimer, Stephen D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
CARM1 Inhibition: Evaluation of Response and Efficacy in Acute Myeloid Leukemia
Mookhtiar, Adnan K, Greenblatt, Sarah, Man, Na, Karl, Daniel, Stathias, Vasileios, Schurer, Stephan, Nimer, Stephen D.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity in Myeloid Neoplasms with Hyperactivated JAK2
Itonaga, Hidehiro, Mookhtiar, Adnan K, Greenblatt, Sarah, Liu, Fan, Martinez, Concepcion, Grozovsky, Renata, Bilbao, Daniel, Rains, Masai, Hamard, Pierre-Jacques, Sun, Jun, Umeano, Afoma, Duffort, Stephanie, Chen, Chuan, Man, Na, Mas Martin, Gloria, Schürer, Stephen, Nimer, Stephen D
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression
Mas, Gloria, Man, Na, Nakata, Yuichiro, Martinez-Caja, Concepcion, Karl, Daniel, Beckedorff, Felipe, Tamiro, Francesco, Chen, Chuan, Duffort, Stephanie, Itonaga, Hidehiro, Mookhtiar, Adnan K, Kunkalla, Kranthi, Valencia, Alfredo M, Collings, Clayton K, Kadoch, Cigall, Vega, Francisco, Kogan, Scott C, Morey, Lluis, Bilbao, Daniel, Nimer, Stephen D
Published in The Journal of clinical investigation (01.07.2023)
Published in The Journal of clinical investigation (01.07.2023)
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Journal Article
The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks
Mas Martin, Gloria, Man, Na, Karl, Daniel, Martinez, Concepcion, Duffort, Stephanie, Itonaga, Hidehiro, Mookhtiar, Adnan K, Bilbao, Daniel, Kunkalla, Kranthi, Valencia, Alfredo M, Collings, Clayton, Kadoch, Cigall, Vega, Francisco, Kogan, Scott C., Nimer, Stephen
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
PRMT5 regulates DNA repair by controlling the alternative splicing of key histone-modifying enzymes
Hamard, Pierre-Jacques, Santiago, Gabriel E., Liu, Fan, Karl, Daniel L., Martinez, Concepcion, Man, Na, Mookhtiar, Adnan K., Duffort, Stephanie, Greenblatt, Sarah, Verdun, Ramiro E., Nimer, Stephen D.
Published in Cell reports (Cambridge) (04.09.2018)
Published in Cell reports (Cambridge) (04.09.2018)
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Journal Article