Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
Jernigan, Finith, Branstrom, Arthur, Baird, John D, Cao, Liangxian, Dali, Mandar, Furia, Bansri, Kim, Min Jung, O'Keefe, Kylie, Kong, Ronald, Laskin, Oscar L, Colacino, Joseph M, Pykett, Mark, Mollin, Anna, Sheedy, Josephine, Dumble, Melissa, Moon, Young-Choon, Sheridan, Richard, Mühlethaler, Tobias, Spiegel, Robert J, Prota, Andrea E, Steinmetz, Michel O, Weetall, Marla
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential
Friesen, Westley J, Johnson, Briana, Sierra, Jairo, Zhuo, Jin, Vazirani, Priya, Xue, Xiaojiao, Tomizawa, Yuki, Baiazitov, Ramil, Morrill, Christie, Ren, Hongyu, Babu, Suresh, Moon, Young-Choon, Branstrom, Art, Mollin, Anna, Hedrick, Jean, Sheedy, Josephine, Elfring, Gary, Weetall, Marla, Colacino, Joseph M, Welch, Ellen M, Peltz, Stuart W
Published in PloS one (25.10.2018)
Published in PloS one (25.10.2018)
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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Branstrom, Arthur, Cao, Liangxian, Furia, Bansri, Trotta, Christopher, Santaguida, Marianne, Graci, Jason D, Colacino, Joseph M, Ray, Balmiki, Li, Wencheng, Sheedy, Josephine, Mollin, Anna, Yeh, Shirley, Kong, Ronald, Sheridan, Richard, Baird, John D, O'Keefe, Kylie, Spiegel, Robert, Goodwin, Elizabeth, Keating, Suzanne, Weetall, Marla
Published in Frontiers in oncology (09.02.2022)
Published in Frontiers in oncology (09.02.2022)
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Structure–Activity Relationship (SAR) Optimization of 6‑(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B
Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil, Venkatraman, Srikanth, Njoroge, F. George, Gu, Zhengxian, Clausen, Valerie, Graci, Jason, Jung, Stephen P., Zheng, Yingcong, Colacino, Joseph M., Lahser, Fred, Sheedy, Josephine, Mollin, Anna, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Comparison of pharmaceutical properties and biological activities of prednisolone, deflazacort, and vamorolone in DMD disease models
Liu, Grace, Lipari, Philip, Mollin, Anna, Jung, Stephen, Teplova, Irina, Li, Wencheng, Ying, Lanqing, More, Vijay, Lennox, William, Yeh, Shirley, McGann, Eric, Moon, Young-Choon, Rice, Cari, Huarte, Eduardo, Gruszka, Barbara, Ray, Balmiki, Goodwin, Elizabeth, Buckendahl, Patricia, Yurkow, Edward, Braughton, Bruce, Narasimhan, Jana, Welch, Ellen, Voronin, Gregory, Weetall, Marla
Published in Human molecular genetics (20.01.2024)
Published in Human molecular genetics (20.01.2024)
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Preclinical studies of gene replacement therapy for CDKL5 deficiency disorder
Voronin, Gregory, Narasimhan, Jana, Gittens, Jamila, Sheedy, Josephine, Lipari, Philip, Peters, Melinda, DeMarco, Steven, Cao, Liangxian, Varganov, Yakov, Kim, Min Jung, Pear, Lisset, Fotouh, Eman, Sinha, Supriya, Ray, Balmiki, Wu, Michael C., Yalamanchili, Padmaja, Southgate, Christopher, Pick, Joseph, Saadipour, Khalil, Jung, Stephen, Lee, Jeanee, Mollin, Anna, Welch, Ellen M., Wu, Zhijian, Weetall, Marla
Published in Molecular therapy (02.10.2024)
Published in Molecular therapy (02.10.2024)
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Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay
Zaworski, Phillip G., Schwartz, Rachel, Burr, Jeffrey, Skutnik, Daniel, Mollin, Anna, Kumar, Binit, Ngumah, Quintus, Welch, Ellen, Johnson, Briana, Narasimhan, Jana, Weetall, Marla
Published in Analytical biochemistry (01.11.2022)
Published in Analytical biochemistry (01.11.2022)
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Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo
Baiazitov, Ramil Y., Friesen, Westley, Johnson, Briana, Mollin, Anna, Sheedy, Josephine, Sierra, Jairo, Weetall, Marla, Branstrom, Arthur, Welch, Ellen, Moon, Young-Choon
Published in Carbohydrate research (01.09.2020)
Published in Carbohydrate research (01.09.2020)
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Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
Eberle-Singh, Jaime A, Sagalovskiy, Irina, Maurer, H Carlo, Sastra, Stephen A, Palermo, Carmine F, Decker, Amanda R, Kim, Min Jung, Sheedy, Josephine, Mollin, Anna, Cao, Liangxian, Hu, Jianhua, Branstrom, Arthur, Weetall, Marla, Olive, Kenneth P
Published in Clinical cancer research (15.09.2019)
Published in Clinical cancer research (15.09.2019)
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SMN protein is required throughout life to prevent spinal muscular atrophy disease progression
Zhao, Xin, Feng, Zhihua, Risher, Nicole, Mollin, Anna, Sheedy, Josephine, Ling, Karen K Y, Narasimhan, Jana, Dakka, Amal, Baird, John D, Ratni, Hasane, Lutz, Catherine, Chen, Karen S, Naryshkin, Nikolai A, Ko, Chien-Ping, Welch, Ellen, Metzger, Friedrich, Weetall, Marla
Published in Human molecular genetics (17.12.2021)
Published in Human molecular genetics (17.12.2021)
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Development of an oral treatment that rescues gait ataxia and retinal degeneration in a phenotypic mouse model of familial dysautonomia
Morini, Elisabetta, Chekuri, Anil, Logan, Emily M., Bolduc, Jessica M., Kirchner, Emily G., Salani, Monica, Krauson, Aram J., Narasimhan, Jana, Gabbeta, Vijayalakshmi, Grover, Shivani, Dakka, Amal, Mollin, Anna, Jung, Stephen P., Zhao, Xin, Zhang, Nanjing, Zhang, Sophie, Arnold, Michael, Woll, Matthew G., Naryshkin, Nikolai A., Weetall, Marla, Slaugenhaupt, Susan A.
Published in American journal of human genetics (02.03.2023)
Published in American journal of human genetics (02.03.2023)
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PTC124 targets genetic disorders caused by nonsense mutations
Chen, Guangming, Jacobson, Allan, Spatrick, Phyllis, Peltz, Stuart W, Conn, M. Morgan, Friesen, Westley J, Almstead, Neil G, Hedrick, Jean, Campbell, Jeffrey A, Mollin, Anna, Kawana, Masataka, Wilde, Richard G, Yeh, Shirley, Sweeney, H. Lee, Trotta, Christopher R, Khan, Atiyya, Welch, Ellen M, Barton, Elisabeth R, Hirawat, Samit, Turpoff, Anthony A, Weetall, Marla, Ren, Hongyu, Risher, Nicole, Tomizawa, Yuki, Northcutt, Valerie J, Miller, Langdon L, He, Feng, Jones, Stephen, Colacino, Joseph M, Feng, Huisheng, Branstrom, Arthur A, Corson, Donald, Zhuo, Jin, Ju, William D, Patel, Meenal, Moon, Young-Choon, Hwang, Seongwoo, Paushkin, Sergey, Babiak, John, Trifillis, Panayiota, Karp, Gary, Takasugi, James
Published in Nature (03.05.2007)
Published in Nature (03.05.2007)
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Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy
Zhao, Xin, Feng, Zhihua, Ling, Karen K Y, Mollin, Anna, Sheedy, Josephine, Yeh, Shirley, Petruska, Janet, Narasimhan, Jana, Dakka, Amal, Welch, Ellen M, Karp, Gary, Chen, Karen S, Metzger, Friedrich, Ratni, Hasane, Lotti, Francesco, Tisdale, Sarah, Naryshkin, Nikolai A, Pellizzoni, Livio, Paushkin, Sergey, Ko, Chien-Ping, Weetall, Marla
Published in Human molecular genetics (15.05.2016)
Published in Human molecular genetics (15.05.2016)
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