An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H. D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A. M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C. P., Clevers, Hans, Drost, Jarno
Published in Nature communications (11.03.2020)
Published in Nature communications (11.03.2020)
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Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome
Foulkes, William D, Kamihara, Junne, Evans, D Gareth R, Brugières, Laurence, Bourdeaut, Franck, Molenaar, Jan J, Walsh, Michael F, Brodeur, Garrett M, Diller, Lisa
Published in Clinical cancer research (15.06.2017)
Published in Clinical cancer research (15.06.2017)
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Retinoblastoma and Neuroblastoma Predisposition and Surveillance
Kamihara, Junne, Bourdeaut, Franck, Foulkes, William D, Molenaar, Jan J, Mossé, Yaël P, Nakagawara, Akira, Parareda, Andreu, Scollon, Sarah R, Schneider, Kami Wolfe, Skalet, Alison H, States, Lisa J, Walsh, Michael F, Diller, Lisa R, Brodeur, Garrett M
Published in Clinical cancer research (01.07.2017)
Published in Clinical cancer research (01.07.2017)
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Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
Valentijn, Linda J, Koster, Jan, Haneveld, Franciska, Aissa, Rachida Ait, van Sluis, Peter, Broekmans, Marloes E. C, Molenaar, Jan J, van Nes, Johan, Versteeg, Rogier
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
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Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders
Walsh, Michael F, Chang, Vivian Y, Kohlmann, Wendy K, Scott, Hamish S, Cunniff, Christopher, Bourdeaut, Franck, Molenaar, Jan J, Porter, Christopher C, Sandlund, John T, Plon, Sharon E, Wang, Lisa L, Savage, Sharon A
Published in Clinical cancer research (01.06.2017)
Published in Clinical cancer research (01.06.2017)
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TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
Decaesteker, Bieke, Denecker, Geertrui, Van Neste, Christophe, Dolman, Emmy M., Van Loocke, Wouter, Gartlgruber, Moritz, Nunes, Carolina, De Vloed, Fanny, Depuydt, Pauline, Verboom, Karen, Rombaut, Dries, Loontiens, Siebe, De Wyn, Jolien, Kholosy, Waleed M., Koopmans, Bianca, Essing, Anke H. W., Herrmann, Carl, Dreidax, Daniel, Durinck, Kaat, Deforce, Dieter, Van Nieuwerburgh, Filip, Henssen, Anton, Versteeg, Rogier, Boeva, Valentina, Schleiermacher, Gudrun, van Nes, Johan, Mestdagh, Pieter, Vanhauwaert, Suzanne, Schulte, Johannes H., Westermann, Frank, Molenaar, Jan J., De Preter, Katleen, Speleman, Frank
Published in Nature communications (19.11.2018)
Published in Nature communications (19.11.2018)
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The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia
Noort, Sanne, Wander, Priscilla, Alonzo, Todd A, Smith, Jenny, Ries, Rhonda E, Gerbing, Robert B, Dolman, M Emmy M, Locatelli, Franco, Reinhardt, Dirk, Baruchel, Andre, Stary, Jan, Molenaar, Jan J, Stam, Ronald W, van den Heuvel-Eibrink, Marry M, Zwaan, Michel C, Meshinchi, Soheil
Published in Haematologica (Roma) (01.02.2021)
Published in Haematologica (Roma) (01.02.2021)
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Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory
Villalard, Benjamin, Boltjes, Arjan, Reynaud, Florie, Imbaud, Olivier, Thoinet, Karine, Timmerman, Ilse, Croze, Séverine, Theoulle, Emy, Atzeni, Gianluigi, Lachuer, Joël, Molenaar, Jan J., Tytgat, Godelieve A. M., Delloye-Bourgeois, Céline, Castellani, Valérie
Published in Nature communications (06.11.2024)
Published in Nature communications (06.11.2024)
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Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics
Gerven, Michael R., Bozsaky, Eva, Matser, Yvette A. H., Vosseberg, Julian, Taschner‐Mandl, Sabine, Koster, Jan, Tytgat, Godelieve A. M., Molenaar, Jan J., Boogaard, Marlinde
Published in Cancer science (01.06.2022)
Published in Cancer science (01.06.2022)
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Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
Calandrini, Camilla, van Hooff, Sander R., Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M., Langenberg, Karin P.S., van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., Drost, Jarno
Published in Cell reports (Cambridge) (24.08.2021)
Published in Cell reports (Cambridge) (24.08.2021)
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Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
Molenaar, Jan J, Ebus, Marli E, Geerts, Dirk, Koster, Jan, Lamers, Fieke, Valentijn, Linda J, Westerhout, Ellen M, Versteeg, Rogier, Caron, Huib N
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
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Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids
Kluiver, Thomas A., Lu, Yuyan, Schubert, Stephanie A., Kraaier, Lianne J., Ringnalda, Femke, Lijnzaad, Philip, DeMartino, Jeff, Megchelenbrink, Wouter L., Amo-Addae, Vicky, Eising, Selma, de Faria, Flavia W., Münter, Daniel, van de Wetering, Marc, Kerl, Kornelius, Duiker, Evelien, van den Heuvel, Marius C., de Meijer, Vincent E., de Kleine, Ruben H., Molenaar, Jan J., Margaritis, Thanasis, Stunnenberg, Hendrik G., de Krijger, Ronald R., Zsiros, József, Clevers, Hans, Peng, Weng Chuan
Published in Nature communications (20.11.2024)
Published in Nature communications (20.11.2024)
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Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS
van Belzen, Ianthe A E M, Cai, Casey, van Tuil, Marc, Badloe, Shashi, Strengman, Eric, Janse, Alex, Verwiel, Eugène T P, van der Leest, Douwe F M, Kester, Lennart, Molenaar, Jan J, Meijerink, Jules, Drost, Jarno, Peng, Weng Chuan, Kerstens, Hindrik H D, Tops, Bastiaan B J, Holstege, Frank C P, Kemmeren, Patrick, Hehir-Kwa, Jayne Y
Published in BMC cancer (03.07.2023)
Published in BMC cancer (03.07.2023)
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The potential of PARP as a therapeutic target across pediatric solid malignancies
Keller, Kaylee M, Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L, Langenberg, Karin P S, Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M Emmy M, Molenaar, Jan J, van Hooff, Sander R
Published in BMC cancer (05.04.2023)
Published in BMC cancer (05.04.2023)
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Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma
Keller, Kaylee M., Eleveld, Thomas F., Schild, Linda, van den Handel, Kim, van den Boogaard, Marlinde, Amo-Addae, Vicky, Eising, Selma, Ober, Kimberley, Koopmans, Bianca, Looijenga, Leendert, Tytgat, Godelieve A.M., Ylstra, Bauke, Molenaar, Jan J., Dolman, M. Emmy M., van Hooff, Sander R.
Published in Frontiers in oncology (27.09.2022)
Published in Frontiers in oncology (27.09.2022)
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Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity
Bate-Eya, Laurel T, Gierman, Hinco J, Ebus, Marli E, Koster, Jan, Caron, Huib N, Versteeg, Rogier, Dolman, M. Emmy M, Molenaar, Jan J
Published in European journal of cancer (1990) (01.04.2017)
Published in European journal of cancer (1990) (01.04.2017)
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Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma
George, Sally L, Lorenzi, Federica, King, David, Hartlieb, Sabine, Campbell, James, Pemberton, Helen, Toprak, Umut H, Barker, Karen, Tall, Jennifer, da Costa, Barbara Martins, van den Boogaard, Marlinde L, Dolman, M Emmy M, Molenaar, Jan J, Bryant, Helen E, Westermann, Frank, Lord, Christopher J, Chesler, Louis
Published in EBioMedicine (01.09.2020)
Published in EBioMedicine (01.09.2020)
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A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery
Jeremiasse, Bernadette, van Ineveld, Ravian L, Bok, Veerle, Kleinnijenhuis, Michiel, de Blank, Sam, Alieva, Maria, Johnson, Hannah R, van Vliet, Esmée J, Zeeman, Amber L, Wellens, Lianne M, Llibre-Palomar, Gerard, Barrera Román, Mario, Di Maggio, Alessia, Dekkers, Johanna F, Oliveira, Sabrina, Vahrmeijer, Alexander L, Molenaar, Jan J, Wijnen, Marc HWA, van der Steeg, Alida FW, Wehrens, Ellen J, Rios, Anne C
Published in EMBO molecular medicine (03.06.2024)
Published in EMBO molecular medicine (03.06.2024)
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