Safety, Tolerability, and Pharmacokinetics of Ropanicant (SUVN-911), a Novel Alpha4 Beta2 Nicotinic Acetylcholine Receptor (α4β2 nAChR) Antagonist, in Healthy Adult and Elderly Subjects
Nirogi, Ramakrishna, Benade, Vijay, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Mohammed, Abdul Rasheed, Shinde, Anil, Dogiparti, Dhanunjay, Ravula, Jyothsna, Jetta, Satish, Palacharla, Veera Raghava Chowdary
Published in Clinical drug investigation (01.09.2022)
Published in Clinical drug investigation (01.09.2022)
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Journal Article
Wide-field choroidal vascular analysis in central serous chorioretinopathy
Singh, Sumit Randhir, Invernizzi, Alessandro, Rasheed, Mohammed Abdul, Cagini, Carlo, Goud, Abhilash, Gujar, Ramkailash, Vupparaboina, Kiran Kumar, Ankireddy, Samatha, Cozzi, Mariano, Lupidi, Marco, Chablani, Jay
Published in European journal of ophthalmology (01.09.2021)
Published in European journal of ophthalmology (01.09.2021)
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Journal Article
Masupirdine (SUVN‐502): A promising clinical candidate for the management of agitation in Alzheimer’s dementia
Nirogi, Ramakrishna, Jayarajan, Pradeep, Tadiparthi, Jayaprakash, Shinde, Anil K, Rasheed, Mohammed Abdul, Goyal, Vinod Kumar, Bhyrapuneni, Gopinadh, Benade, Vijay, Palacharla, Veera Raghava Chowdary, Ravula, Jyothsna, Jetta, Satish
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
SUVN‐D4010: A serotonin‐4 receptor partial agonist for the treatment of cognitive disorders
Medapati, Rajesh Babu, Ganuga, Narender, Mekala, Venkat Reddy, Bhyrapuneni, Gopinadh, Thentu, Jagadeesh Babu, Daripelli, Saivishal, Gagginapalli, Shankar Reddy, Bogaraju, Narsimha, Rasheed, Mohammed Abdul, Nirogi, Ramakrishna
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease
Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K., Bogaraju, Narsimha, Gagginapalli, Shankar Reddy, Ravella, Srinivasa Rao, Kota, Laxman, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Benade, Vijay, Palacharla, Raghava Chowdary, Jayarajan, Pradeep, Subramanian, Ramkumar, Goyal, Vinod Kumar
Published in European journal of medicinal chemistry (20.10.2015)
Published in European journal of medicinal chemistry (20.10.2015)
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Journal Article
Effects of Masupirdine (SUVN‐502) on Agitation/Aggression and Psychosis in Patients with Probable Alzheimer’s Disease: A Post Hoc Analysis
Nirogi, Ramakrishna, Jayarajan, Pradeep, Abraham, Renny, Tadiparthi, Jayaprakash, Benade, Vijay, Shinde, Anil K, Rasheed, Mohammed Abdul, Badange, Rajesh Kumar, Goyal, Vinod Kumar, Palacharla, Veera Raghava Chowdary, Ravulu, Jyothsna, Jetta, Satish, Subramanian, Ramkumar
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Effect of Concurrent Use of Memantine on The Efficacy of Masupirdine (SUVN‐502): A Post‐hoc Analysis of a Phase‐2 Randomized Placebo‐Controlled Study
Goyal, Vinod Kumar, Pandey, Santosh Kumar, Benade, Vijay, Shinde, Anil K, Rasheed, Mohammed Abdul, Badange, Rajesh Kumar, Palacharla, Veera Raghava Chowdary, Ravulu, Jyothsna, Jetta, Satish, Subramanian, Ramkumar, Nirogi, Ramakrishna
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Correlation of sectoral choroidal vascularity with angiographic leakage in central serous chorioretinopathy
Singh, Sumit Randhir, Beale, Oliver, Nkrumah, Gideon, Rasheed, Mohammed Abdul, Sahoo, Niroj Kumar, Vupparaboina, Kiran Kumar, Tatti, Filippo, Chandra, Khushboo, Iovino, Claudio, Peiretti, Enrico, Chhablani, Jay
Published in European journal of ophthalmology (01.03.2022)
Published in European journal of ophthalmology (01.03.2022)
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Journal Article
Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (H3R) inverse agonist in clinical development for the treatment of narcolepsy
Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Manoharan, Arunkumar, Shinde, Anil K, Mohammed, Abdul Rasheed, Padala, Nagasurya Prakash, Ajjala, Devender Reddy, Subramanian, Ramkumar, Palacharla, Veera Raghava Chowdary
Published in European journal of pharmaceutical sciences (01.09.2020)
Published in European journal of pharmaceutical sciences (01.09.2020)
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Journal Article
Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT 4 Receptor Partial Agonists
Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Middekadi, Vanaja Reddy, Bogaraju, Narsimha, Ravella, Srinivasa Rao, Singh, Pooja, Birangal, Sumit Raosaheb, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Jayarajan, Pradeep
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Journal Article
Discovery and Development of 3‑(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression
Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Ravella, Srinivasa Rao, Bogaraju, Narsimha, Subramanian, Ramkumar, Mekala, Venkat Reddy, Palacharla, Raghava Choudary, Muddana, Nageswararao, Thentu, Jagadeesh Babu, Bhyrapuneni, Gopinadh, Abraham, Renny, Jasti, Venkat
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
First-in-Human Studies to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Novel 5-HT4 Partial Agonist, SUVN-D4010, in Healthy Adult and Elderly Subjects
Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Mohammed, Abdul Rasheed, Ravula, Jyothsna, Jetta, Satish, Palacharla, Veera Raghava Chowdary
Published in Clinical drug investigation (01.05.2021)
Published in Clinical drug investigation (01.05.2021)
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Journal Article
Masupirdine (SUVN‐502) in combination with donepezil and memantine in moderate Alzheimer's disease: Effect of AD duration since diagnosis and patient’s age on efficacy endpoints
Nirogi, Ramakrishna, Shinde, Anil K, Benade, Vijay, Subramanian, Ramkumar, Bhyrapuneni, Gopinadh, Ravulu, Jyothsna, Jetta, Satish, Rasheed, Mohammed Abdul, Badange, Rajesh Kumar, Jasti, Venkat
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Masupirdine (SUVN‐502) in combination with donepezil and memantine in moderate Alzheimer's disease: Effect of AD duration since diagnosis and patient’s age on efficacy endpoints: Human/Human trials: Cognitive enhancement
Nirogi, Ramakrishna, Shinde, Anil K, Benade, Vijay, Subramanian, Ramkumar, Bhyrapuneni, Gopinadh, Ravulu, Jyothsna, Jetta, Satish, Rasheed, Mohammed Abdul, Badange, Rajesh Kumar, Jasti, Venkat
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT 4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer’s Disease
Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil Karbhari, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Ravella, Srinivasa Rao, Bogaraju, Narsimha, Middekadi, Vanaja Reddy, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Abraham, Renny, Medapati, Rajesh Babu, Thentu, Jagadeesh Babu, Mekala, Venkat Reddy, Petlu, Surendra, Lingavarapu, Bujji Babu, Yarra, Sivasekhar, Kagita, Narendra, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Jasti, Venkat
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Safety, Tolerability, and Pharmacokinetics of SUVN-G3031, a Novel Histamine-3 Receptor Inverse Agonist for the Treatment of Narcolepsy, in Healthy Human Subjects Following Single and Multiple Oral Doses
Nirogi, Ramakrishna, Mudigonda, Koteshwara, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Shinde, Anil, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Mohammed, Abdul Rasheed, Ravula, Jyothsna, Jetta, Satish, Palacharla, Veera Raghava Chowdary
Published in Clinical drug investigation (01.07.2020)
Published in Clinical drug investigation (01.07.2020)
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Journal Article
A selective and accurate liquid chromatography-tandem mass spectrometry method for the quantitation of the novel 5-HT 4 receptor partial agonist SUVN-D4010 (Usmarapride) in human plasma and urine
Nirogi, Ramakrishna, Kalaikadhiban, Ilayaraja, Padala, Naga Surya Prakash, Pantangi, Hanumanth Rao, Chunduru, Prathyusha, Mohammed, Abdul Rasheed
Published in Journal of pharmaceutical and biomedical analysis (20.03.2022)
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Published in Journal of pharmaceutical and biomedical analysis (20.03.2022)
Journal Article
Discovery and Development of 1‑[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]‑1H‑indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer’s Disease
Nirogi, Ramakrishna, Shinde, Anil, Kambhampati, Rama Sastry, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Badange, Rajesh kumar, Bandyala, Thrinath Reddy, Bhatta, Venugopalarao, Bojja, Kumar, Reballi, Veena, Subramanian, Ramkumar, Benade, Vijay, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Jayarajan, Pradeep, Goyal, Vinod, Jasti, Venkat
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction
Nirogi, Ramakrishna, Palacharla, Raghava Choudary, Mohammed, Abdul Rasheed, Manoharan, Arunkumar, Ponnamaneni, Ranjith kumar, Bhyrapuneni, Gopinadh
Published in Chemico-biological interactions (25.03.2015)
Published in Chemico-biological interactions (25.03.2015)
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Journal Article
Safety of 5914 intravitreal ziv-aflibercept injections
Singh, Sumit Randhir, Stewart, Michael W, Chattannavar, Goura, Ashraf, Mohammed, Souka, Ahmed, ElDardeery, Mazen, Wadhwa, Neeraj, Sarvaiya, Chintan, Mansour, Ahmad M, Marashi, Ameen, Ramchandani, Suresh, Braimah, Imoro Zeba, Jabbarpoor Bonyadi, Mohammad Hossein, Ramezani, Alireza, Soheilian, Masoud, de Oliveira Dias, João Rafael, de Andrade, Gabriel Costa, Maia, André, Rodrigues, Eduardo Büchele, Farah, Michel Eid, Banker, Alay, Chhablani, Jay
Published in British journal of ophthalmology (01.06.2019)
Published in British journal of ophthalmology (01.06.2019)
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Journal Article