A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding
Sade, Hadassah, Baumgartner, Claudia, Hugenmatter, Adrian, Moessner, Ekkehard, Freskgård, Per-Ola, Niewoehner, Jens
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J, Gerrits, Danny, Geven, Edwin J W, Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J Mark, Garg, Pradeep K, Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors
Román Alonso, Macarena, Grinyó-Escuer, Ariadna, Duro-Sánchez, Santiago, Rius-Ruiz, Irene, Bort-Brusca, Marta, Escorihuela, Marta, Maqueda-Marcos, Susana, Pérez-Ramos, Sandra, Gago, Judit, Nogales, Vanesa, Espinosa-Bravo, Martín, Peg, Vicente, Escrivá-de-Romaní, Santiago, Foradada, Laia, Soucek, Laura, Braña, Irene, Galvao, Vladimir, Martín-Lluesma, Silvia, Moessner, Ekkehard, Klein, Christian, Garralda, Elena, Saura, Cristina, Arribas, Joaquín
Published in Nature communications (18.11.2024)
Published in Nature communications (18.11.2024)
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Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure
Lotz, Gregor P, Lutz, Achim, Martin-Facklam, Meret, Hansbauer, Andre, Schick, Eginhard, Moessner, Ekkehard, Antony, Michael, Stuchly, Thomas, Viert, Maria, Hosse, Ralf J, Freimoser-Grundschober, Anne, Klein, Christian, Schäfer, Martin, Ritter, Mirko, Stubenrauch, Kay-Gunnar
Published in Frontiers in immunology (31.05.2024)
Published in Frontiers in immunology (31.05.2024)
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Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
Stock, Sophia, Benmebarek, Mohamed-Reda, Kluever, Anna-Kristina, Darowski, Diana, Jost, Christian, Stubenrauch, Kay-Gunnar, Benz, Joerg, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Subklewe, Marion, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Published in Journal for immunotherapy of cancer (01.07.2022)
Published in Journal for immunotherapy of cancer (01.07.2022)
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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments
Fernández-Quintero, Monica L, Kroell, Katharina B, Heiss, Martin C, Loeffler, Johannes R, Quoika, Patrick K, Waibl, Franz, Bujotzek, Alexander, Moessner, Ekkehard, Georges, Guy, Liedl, Klaus R
Published in Frontiers in molecular biosciences (24.11.2020)
Published in Frontiers in molecular biosciences (24.11.2020)
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Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Danny, Gerrits, Boerman, Otto, Nayak, Tapan, Herter, Sylvia, Van Puijenbroek, Erwin, Ast, Oliver, Hofer, Thomas, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Neubauer, Markus, Gorr, Ingo, Tuerck, Dietrich, Evers, Stefan, Gerdes, Christian, Levitsky, Victor, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
Schlothauer, Tilman, Herter, Sylvia, Koller, Claudia Ferrara, Grau-Richards, Sandra, Steinhart, Virginie, Spick, Christian, Kubbies, Manfred, Klein, Christian, Umaña, Pablo, Mössner, Ekkehard
Published in Protein engineering, design and selection (01.10.2016)
Published in Protein engineering, design and selection (01.10.2016)
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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Journal Article
Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties
Klein, Christian, Lammens, Alfred, Schäfer, Wolfgang, Georges, Guy, Schwaiger, Manfred, Mössner, Ekkehard, Hopfner, Karl-Peter, Umaña, Pablo, Niederfellner, Gerhard
Published in mAbs (01.01.2013)
Published in mAbs (01.01.2013)
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.
Published in Journal of autoimmunity (01.12.2018)
Published in Journal of autoimmunity (01.12.2018)
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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity
Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo
Published in Blood (03.06.2010)
Published in Blood (03.06.2010)
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이종이량체 Fc 도메인 항체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 20.03.2024
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Year of Publication 20.03.2024
Patent
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
Niederfellner, Gerhard, Lammens, Alfred, Mundigl, Olaf, Georges, Guy J., Schaefer, Wolfgang, Schwaiger, Manfred, Franke, Andreas, Wiechmann, Kornelius, Jenewein, Stefan, Slootstra, Jerry W., Timmerman, Peter, Brännström, Annika, Lindstrom, Frida, Mössner, Ekkehard, Umana, Pablo, Hopfner, Karl-Peter, Klein, Christian
Published in Blood (14.07.2011)
Published in Blood (14.07.2011)
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개선된 항원 결합 수용체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
Patent
GA201 (RG7160): A Novel, Humanized, Glycoengineered Anti-EGFR Antibody with Enhanced ADCC and Superior In Vivo Efficacy Compared with Cetuximab
GERDES, Christian A, NICOLINI, Valeria Gonzalez, BOSSENMAIER, Birgit, MUELLER, Hans Joachim, UMANA, Pablo, HERTER, Sylvia, PUIJENBROEK, Erwin Van, LANG, Sabine, ROEMMELE, Michaela, MOESSNER, Ekkehard, FREYTAG, Olivier, FRIESS, Thomas, RIES, Carola H
Published in Clinical cancer research (01.03.2013)
Published in Clinical cancer research (01.03.2013)
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Immuno-PET and Immuno-SPECT of Rheumatoid Arthritis with Radiolabeled Anti-Fibroblast Activation Protein Antibody Correlates with Severity of Arthritis
Laverman, Peter, van der Geest, Tessa, Terry, Samantha Y A, Gerrits, Danny, Walgreen, Birgitte, Helsen, Monique M, Nayak, Tapan K, Freimoser-Grundschober, Anne, Waldhauer, Inja, Hosse, Ralf J, Moessner, Ekkehard, Umana, Pablo, Klein, Christian, Oyen, Wim J G, Koenders, Marije I, Boerman, Otto C
Published in Journal of Nuclear Medicine (01.05.2015)
Published in Journal of Nuclear Medicine (01.05.2015)
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