Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Hochheiser, Inga V., Pilsl, Michael, Hagelueken, Gregor, Moecking, Jonas, Marleaux, Michael, Brinkschulte, Rebecca, Latz, Eicke, Engel, Christoph, Geyer, Matthias
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Journal Article
Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice
Yu, Chien-Hsiung, Moecking, Jonas, Geyer, Matthias, Masters, Seth L.
Published in Journal of molecular biology (19.01.2018)
Published in Journal of molecular biology (19.01.2018)
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Journal Article
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
Kopp, Anja, Hagelueken, Gregor, Jamitzky, Isabell, Moecking, Jonas, Schiffelers, Lisa D. J., Schmidt, Florian I., Geyer, Matthias
Published in Nature communications (01.12.2023)
Published in Nature communications (01.12.2023)
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Journal Article
Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter
Peter, Martin F., Ruland, Jan A., Depping, Peer, Schneberger, Niels, Severi, Emmanuele, Moecking, Jonas, Gatterdam, Karl, Tindall, Sarah, Durand, Alexandre, Heinz, Veronika, Siebrasse, Jan Peter, Koenig, Paul-Albert, Geyer, Matthias, Ziegler, Christine, Kubitscheck, Ulrich, Thomas, Gavin H., Hagelueken, Gregor
Published in Nature communications (04.08.2022)
Published in Nature communications (04.08.2022)
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Journal Article
Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus
Steiner, Annemarie, Reygaerts, Thomas, Pontillo, Alessandra, Ceccherini, Isabella, Moecking, Jonas, Moghaddas, Fiona, Davidson, Sophia, Caroli, Francesco, Grossi, Alice, Castro, Fabio Fernandes Morato, Kalil, Jorge, Gohr, Florian N., Schmidt, Florian I., Bartok, Eva, Zillinger, Thomas, Hartmann, Gunther, Geyer, Matthias, Gattorno, Marco, Mendonça, Leonardo Oliveira, Masters, Seth L.
Published in Journal of clinical immunology (01.02.2022)
Published in Journal of clinical immunology (01.02.2022)
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Journal Article
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
Jenster, Lea-Marie, Lange, Karl-Elmar, Normann, Sabine, vom Hemdt, Anja, Wuerth, Jennifer D, Schiffelers, Lisa D J, Tesfamariam, Yonas M, Gohr, Florian N, Klein, Laura, Kaltheuner, Ines H, Ebner, Stefan, Lapp, Dorothee J, Mayer, Jacob, Moecking, Jonas, Ploegh, Hidde L, Latz, Eicke, Meissner, Felix, Geyer, Matthias, Kümmerer, Beate M, Schmidt, Florian I
Published in The Journal of experimental medicine (02.01.2023)
Published in The Journal of experimental medicine (02.01.2023)
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Journal Article
Antiviral signalling by a cyclic nucleotide activated CRISPR protease
Rouillon, Christophe, Schneberger, Niels, Chi, Haotian, Blumenstock, Katja, Da Vela, Stefano, Ackermann, Katrin, Moecking, Jonas, Peter, Martin F., Boenigk, Wolfgang, Seifert, Reinhard, Bode, Bela E., Schmid-Burgk, Jonathan L., Svergun, Dmitri, Geyer, Matthias, White, Malcolm F., Hagelueken, Gregor
Published in Nature (London) (02.02.2023)
Published in Nature (London) (02.02.2023)
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Journal Article
The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation
Schmitz, Maximilian, Kaltheuner, Ines H, Anand, Kanchan, Düster, Robert, Moecking, Jonas, Monastyrskyi, Andrii, Duckett, Derek R, Roush, William R, Geyer, Matthias
Published in The Journal of biological chemistry (01.01.2024)
Published in The Journal of biological chemistry (01.01.2024)
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Journal Article
Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain
Moecking, Jonas, Laohamonthonkul, Pawat, Meşe, Kubilay, Hagelueken, Gregor, Steiner, Annemarie, Harapas, Cassandra R., Sandow, Jarrod J., Graves, Jonathan D., Masters, Seth L., Geyer, Matthias
Published in The Journal of biological chemistry (01.12.2022)
Published in The Journal of biological chemistry (01.12.2022)
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Journal Article
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Yu, Chien-Hsiung, Davidson, Sophia, Harapas, Cassandra R., Hilton, James B., Mlodzianoski, Michael J., Laohamonthonkul, Pawat, Louis, Cynthia, Low, Ronnie Ren Jie, Moecking, Jonas, De Nardo, Dominic, Balka, Katherine R., Calleja, Dale J., Moghaddas, Fiona, Ni, Erya, McLean, Catriona A., Samson, Andre L., Tyebji, Shiraz, Tonkin, Christopher J., Bye, Christopher R., Turner, Bradley J., Pepin, Genevieve, Gantier, Michael P., Rogers, Kelly L., McArthur, Kate, Crouch, Peter J., Masters, Seth L.
Published in Cell (29.10.2020)
Published in Cell (29.10.2020)
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NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity
Moecking, Jonas, Laohamonthonkul, Pawat, Chalker, Katelyn, White, Marquitta J., Harapas, Cassandra R., Yu, Chien-Hsiung, Davidson, Sophia, Hrovat-Schaale, Katja, Hu, Donglei, Eng, Celeste, Huntsman, Scott, Calleja, Dale J., Horvat, Jay C., Hansbro, Phil M., O’Donoghue, Robert J.J., Ting, Jenny P., Burchard, Esteban G., Geyer, Matthias, Gerlic, Motti, Masters, Seth L.
Published in Journal of allergy and clinical immunology (01.06.2021)
Published in Journal of allergy and clinical immunology (01.06.2021)
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Journal Article
Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules
TRENHOLME, Katharine, MAREK, Linda, GOODMAN, Christopher D, MCFADDEN, Geoffrey I, SUMANADASA, Subathdrage D. M, FAIRLIE, David P, AVERY, Vicky M, KURZ, Thomas, ANDREWS, Katherine T, DUFFY, Sandra, PRADEL, Gabriele, FISHER, Gillian, HANSEN, Finn K, SKINNER-ADAMS, Tina S, BUTTERWORTH, Alice, NGWA, Che Julius, MOECKING, Jonas
Published in Antimicrobial agents and chemotherapy (01.07.2014)
Published in Antimicrobial agents and chemotherapy (01.07.2014)
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Journal Article
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
Lea-Marie Jenster, Lange, Karl-Elmar, Normann, Sabine, Anja Vom Hemdt, Wuerth, Jennifer Deborah, Lisa Dominica Jacoba Schiffelers, Yonas Mehari Tesfamariam, Gohr, Florian Nikolaus, Klein, Laura, Kaltheuner, Ines H, Lapp, Dorothee Johanna, Mayer, Jacob, Moecking, Jonas, Ploegh, Hidde L, Latz, Eicke, Geyer, Matthias, Kuemmerer, Beate Mareike, Florian Ingo Schmidt
Published in bioRxiv (25.01.2022)
Published in bioRxiv (25.01.2022)
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