Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models
Singh Mali, Raghuveer, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F, Dail, Monique, Shah, Neil P, Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A
Published in Haematologica (Roma) (01.04.2021)
Published in Haematologica (Roma) (01.04.2021)
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Journal Article
SYNFAC-EDIT: Synthetic Imitation Edit Feedback for Factual Alignment in Clinical Summarization
Mishra, Prakamya, Yao, Zonghai, Vashisht, Parth, Ouyang, Feiyun, Wang, Beining, Vidhi Dhaval Mody, Yu, Hong
Published in arXiv.org (18.04.2024)
Published in arXiv.org (18.04.2024)
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Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O'Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Abstract 3406: GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility in vivo
Metcalfe, Ciara, Zhou, Wei, Guan, Jane, Blake, Robert A., De Bruyn, Tom, Giltnane, Jennifer M., Ingalla, Ellen, Kleinheinz, Tracy, Liang, Jun, Mody, Vidhi, Oeh, Jason, Ubhayakar, Savita, Wertz, Ingrid, Young, Amy, Zbieg, Jason, Wang, Xiaojing, Hafner, Marc
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer
Zbieg, Jason R., Liang, Jun, Li, Jun, Blake, Robert A., Chang, Jae, Friedman, Lori, Goodacre, Simon, Hartman, Steven J., Rei Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Lai, Tommy, Liao, Jiangpeng, McLean, Nev, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
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Journal Article
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha
Zhang, Birong, Kiefer, James R., Blake, Robert A., Chang, Jae H., Hartman, Steven, Ingalla, Ellen Rei, Kleinheinz, Tracy, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Zhong, Yu, Nwachukwu, Jerome C., Nettles, Kendall W., Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Chen, Hai, Wang, Xiaojing, Liang, Jun
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
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Journal Article
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Labadie, Sharada S., Li, Jun, Blake, Robert A., Chang, Jae H., Goodacre, Simon, Hartman, Steven J., Liang, Weiling, Kiefer, James R., Kleinheinz, Tracy, Lai, Tommy, Liao, Jiangpeng, Ortwine, Daniel F., Mody, Vidhi, Ray, Nicholas C., Roussel, Fabien, Vinogradova, Maia, Yeap, Siew Kuen, Zhang, Birong, Zheng, Xiaoping, Zbieg, Jason R., Liang, Jun, Wang, Xiaojing
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER plus Breast Cancer
Liang, Jun, Blake, Robert, Chang, Jae, Friedman, Lori S., Goodacre, Simon, Hartman, Steven, Ingalla, Ellen Rei, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Li, Jun, Lai, Kwong Wah, Liao, Jiangpeng, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle, Ortwine, Daniel, Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Young, Amy, Zbieg, Jason, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer
Liang, Jun, Blake, Robert, Chang, Jae, Friedman, Lori S, Goodacre, Simon, Hartman, Steven, Ingalla, Ellen Rei, Kiefer, James R, Kleinheinz, Tracy, Labadie, Sharada, Li, Jun, Lai, Kwong Wah, Liao, Jiangpeng, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle, Otwine, Daniel, Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Young, Amy, Zbieg, Jason, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Physiologically Based Pharmacokinetic Model for Composite Nanodevices: Effect of Charge and Size on In Vivo Disposition
Mager, Donald E., Mody, Vidhi, Xu, Chao, Forrest, Alan, Lesniak, Wojciech G., Nigavekar, Shraddha S., Kariapper, Muhammed T., Minc, Leah, Khan, Mohamed K., Balogh, Lajos P.
Published in Pharmaceutical research (01.09.2012)
Published in Pharmaceutical research (01.09.2012)
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Journal Article
Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927
Kahraman, Mehmet, Govek, Steven P., Nagasawa, Johnny Y., Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D., Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D., Blake, Robert A., Chang, Jae, Choo, Edna, Daemen, Anneleen, Friedman, Lori S., Guan, Jane, Hartman, Steven, Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Sampath, Deepak, Young, Amy, Vinogradova, Maia, Zhou, Wei, Liang, Jun, Wang, Xiaojing
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
A Study on existing Friend Recommendation Systems in social Networks
Mody, Vidhi, Mody, Vrushti
Published in 2020 International Conference on Smart Electronics and Communication (ICOSEC) (01.09.2020)
Published in 2020 International Conference on Smart Electronics and Communication (ICOSEC) (01.09.2020)
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Conference Proceeding
Mental Health Monitoring System using Artificial Intelligence: A Review
Mody, Vidhi, Mody, Vrushti
Published in 2019 IEEE 5th International Conference for Convergence in Technology (I2CT) (01.03.2019)
Published in 2019 IEEE 5th International Conference for Convergence in Technology (I2CT) (01.03.2019)
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Conference Proceeding
Distress - An Application for Emergency Response and Disaster Management
Mody, Vidhi, Mody, Vrushti, Parekh, Soham
Published in 2020 International Conference on Smart Electronics and Communication (ICOSEC) (01.09.2020)
Published in 2020 International Conference on Smart Electronics and Communication (ICOSEC) (01.09.2020)
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Conference Proceeding
Friend.ly: A pilot study for a personality-based friend recommendation system
Mody, Vidhi, Mody, Vrushti, Parekh, Soham, Mistry, Kamal
Published in 2022 IEEE 7th International conference for Convergence in Technology (I2CT) (07.04.2022)
Published in 2022 IEEE 7th International conference for Convergence in Technology (I2CT) (07.04.2022)
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Conference Proceeding
A study on Cloud enabled Applications and their Security Issues
Mody, Vidhi, Mody, Vrushti, Parekh, Soham
Published in 2020 11th International Conference on Computing, Communication and Networking Technologies (ICCCNT) (01.07.2020)
Published in 2020 11th International Conference on Computing, Communication and Networking Technologies (ICCCNT) (01.07.2020)
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Conference Proceeding