Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration
Xu, Wei, Weissmiller, April M, White, 2nd, Joseph A, Fang, Fang, Wang, Xinyi, Wu, Yiwen, Pearn, Matthew L, Zhao, Xiaobei, Sawa, Mariko, Chen, Shengdi, Gunawardena, Shermali, Ding, Jianqing, Mobley, William C, Wu, Chengbiao
Published in The Journal of clinical investigation (01.05.2016)
Published in The Journal of clinical investigation (01.05.2016)
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BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons
Moya-Alvarado, Guillermo, Tiburcio-Felix, Reynaldo, Ibáñez, María Raquel, Aguirre-Soto, Alejandro A, Guerra, Miguel V, Wu, Chengbiao, Mobley, William C, Perlson, Eran, Bronfman, Francisca C
Published in eLife (24.02.2023)
Published in eLife (24.02.2023)
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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease
Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2016)
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Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Zhao, Yingjun, Tseng, I-Chu, Heyser, Charles J., Rockenstein, Edward, Mante, Michael, Adame, Anthony, Zheng, Qiuyang, Huang, Timothy, Wang, Xin, Arslan, Pharhad E., Chakrabarty, Paramita, Wu, Chengbiao, Bu, Guojun, Mobley, William C., Zhang, Yun-wu, St. George-Hyslop, Peter, Masliah, Eliezer, Fraser, Paul, Xu, Huaxi
Published in Neuron (Cambridge, Mass.) (02.09.2015)
Published in Neuron (Cambridge, Mass.) (02.09.2015)
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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
Wang, Xin, Zhao, Yingjun, Zhang, Xiaofei, Badie, Hedieh, Zhou, Ying, Mu, Yangling, Loo, Li Shen, Cai, Lei, Thompson, Robert C, Yang, Bo, Chen, Yaomin, Johnson, Peter F, Wu, Chengbiao, Bu, Guojun, Mobley, William C, Zhang, Dongxian, Gage, Fred H, Ranscht, Barbara, Zhang, Yun-wu, Lipton, Stuart A, Hong, Wanjin, Xu, Huaxi
Published in Nature medicine (01.04.2013)
Published in Nature medicine (01.04.2013)
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One at a time, live tracking of NGF axonal transport using quantum dots
Cui, Bianxiao, Wu, Chengbiao, Chen, Liang, Ramirez, Alfredo, Bearer, Elaine L, Li, Wei-Ping, Mobley, William C, Chu, Steven
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2007)
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BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease
Gu, Yingli, Pope, Alexander, Smith, Charlene, Carmona, Christopher, Johnstone, Aaron, Shi, Linda, Chen, Xuqiao, Santos, Sarai, Bacon-Brenes, Claire Cecile, Shoff, Thomas, Kleczko, Korbin M., Frydman, Judith, Thompson, Leslie M., Mobley, William C., Wu, Chengbiao
Published in Neurobiology of disease (01.06.2024)
Published in Neurobiology of disease (01.06.2024)
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Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks
Belichenko, Pavel V., Wright, Elena E., Belichenko, Nadia P., Masliah, Eliezer, Li, Hong Hua, Mobley, William C., Francke, Uta
Published in Journal of comparative neurology (1911) (20.05.2009)
Published in Journal of comparative neurology (1911) (20.05.2009)
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PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)
Rafii, Michael S, Lukic, Ana S, Andrews, Randolph D, Brewer, James, Rissman, Robert A, Strother, Stephen C, Wernick, Miles N, Pennington, Craig, Mobley, William C, Ness, Seth, Matthews, Dawn C
Published in Journal of Alzheimer's disease (01.01.2017)
Published in Journal of Alzheimer's disease (01.01.2017)
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Journal Article
Genetic dissection of the Down syndrome critical region
Jiang, Xiaoling, Liu, Chunhong, Yu, Tao, Zhang, Li, Meng, Kai, Xing, Zhuo, Belichenko, Pavel V, Kleschevnikov, Alexander M, Pao, Annie, Peresie, Jennifer, Wie, Sarah, Mobley, William C, Yu, Y Eugene
Published in Human molecular genetics (15.11.2015)
Published in Human molecular genetics (15.11.2015)
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Journal Article
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome
Kleschevnikov, Alexander M, Yu, Jessica, Kim, Jeesun, Lysenko, Larisa V, Zhen, Zheng, Eugene Yu, Y, Mobley, William C
Published in Neurobiology of disease (01.07.2017)
Published in Neurobiology of disease (01.07.2017)
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Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1 -adrenergic receptor by xamoterol as a potential cognitive enhancer
Faizi, Mehrdad, Bader, Patrick L, Tun, Christine, Encarnacion, Angelo, Kleschevnikov, Alexander, Belichenko, Pavel, Saw, Nay, Priestley, Matthew, Tsien, Richard W, Mobley, William C, Shamloo, Mehrdad
Published in Neurobiology of disease (01.08.2011)
Published in Neurobiology of disease (01.08.2011)
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Journal Article
The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome
Belichenko, Nadia P, Belichenko, Pavel V, Kleschevnikov, Alexander M, Salehi, Ahmad, Reeves, Roger H, Mobley, William C
Published in The Journal of neuroscience (06.05.2009)
Published in The Journal of neuroscience (06.05.2009)
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Journal Article
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues
Belichenko, Pavel V, Kleschevnikov, Alexander M, Becker, Ann, Wagner, Grant E, Lysenko, Larisa V, Yu, Y Eugene, Mobley, William C
Published in PloS one (31.07.2015)
Published in PloS one (31.07.2015)
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Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships
Belichenko, Pavel V., Kleschevnikov, Alexander M., Salehi, Ahmad, Epstein, Charles J., Mobley, William C.
Published in Journal of comparative neurology (1911) (01.10.2007)
Published in Journal of comparative neurology (1911) (01.10.2007)
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