Pharmacological targeting of the Hsp70 chaperone
Patury, Srikanth, Miyata, Yoshinari, Gestwicki, Jason E
Published in Current topics in medicinal chemistry (01.11.2009)
Published in Current topics in medicinal chemistry (01.11.2009)
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Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
Wang, Adrienne M, Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason P, Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane E, Pratt, William B, Osawa, Yoichi, Collins, Catherine A, Gestwicki, Jason E, Lieberman, Andrew P
Published in Nature chemical biology (01.02.2013)
Published in Nature chemical biology (01.02.2013)
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Journal Article
Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau
Abisambra, Jose, Jinwal, Umesh K, Miyata, Yoshinari, Rogers, Justin, Blair, Laura, Li, Xiaokai, Seguin, Sandlin P, Wang, Li, Jin, Ying, Bacon, Justin, Brady, Sarah, Cockman, Matthew, Guidi, Chantal, Zhang, Juan, Koren, John, Young, Zapporah T, Atkins, Christopher A, Zhang, Bo, Lawson, Lisa Y, Weeber, Edwin J, Brodsky, Jeffrey L, Gestwicki, Jason E, Dickey, Chad A
Published in Biological psychiatry (1969) (01.09.2013)
Published in Biological psychiatry (1969) (01.09.2013)
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Journal Article
Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability
Jinwal, Umesh K, Miyata, Yoshinari, Koren, John, III, Jones, Jeffrey R, Trotter, Justin H, Chang, Lyra, O'Leary, John, Morgan, David, Lee, Daniel C, Shults, Cody L, Rousaki, Aikaterini, Weeber, Edwin J, Zuiderweg, Erik R. P, Gestwicki, Jason E, Dickey, Chad A
Published in The Journal of neuroscience (30.09.2009)
Published in The Journal of neuroscience (30.09.2009)
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Journal Article
Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers
Wang, Xiaobo, Moore, Mary P., Shi, Hongxue, Miyata, Yoshinari, Donnelly, Sara K., Radiloff, Daniel R., Tabas, Ira
Published in Molecular therapy. Methods & clinical development (14.12.2023)
Published in Molecular therapy. Methods & clinical development (14.12.2023)
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Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model
Dent, Matthew, Hamorsky, Krystal, Vausselin, Thibaut, Dubuisson, Jean, Miyata, Yoshinari, Morikawa, Yoshio, Matoba, Nobuyuki
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2021)
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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
Miyata, Yoshinari, Li, Xiaokai, Lee, Hsiu-Fang, Jinwal, Umesh K, Srinivasan, Sharan R, Seguin, Sandlin P, Young, Zapporah T, Brodsky, Jeffrey L, Dickey, Chad A, Sun, Duxin, Gestwicki, Jason E
Published in ACS chemical neuroscience (19.06.2013)
Published in ACS chemical neuroscience (19.06.2013)
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Journal Article
Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels
Koren, John, Jinwal, Umesh K., Jin, Ying, O’Leary, John, Jones, Jeff R., Johnson, Amelia G., Blair, Laura J., Abisambra, Jose F., Chang, Lyra, Miyata, Yoshinari, Cheng, Anna M., Guo, Jianping, Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Published in The Journal of biological chemistry (22.01.2010)
Published in The Journal of biological chemistry (22.01.2010)
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Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease
Than, Khoi D., MD, Rahman, Shayan U., MD, Wang, Lin, MD, Khan, Adam, BA, Kyere, Kwaku A., BA, Than, Tracey T, Miyata, Yoshinari, PhD, Park, Yoon-Shin, PhD, La Marca, Frank, MD, Kim, Hyungjin M., ScD, Zhang, Huina, MD, PhD, Park, Paul, MD, Lin, Chia-Ying, PhD
Published in The spine journal (01.06.2014)
Published in The spine journal (01.06.2014)
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Journal Article
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance
Koren, 3rd, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, 3rd, John C, Nguyen, Lana, Guo, Jianping, Blair, Laura J, Li, Xiaokai, Li, Xiokai, Jinwal, Umesh K, Cheng, Jin Q, Gestwicki, Jason E, Dickey, Chad A
Published in PloS one (26.04.2012)
Published in PloS one (26.04.2012)
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Journal Article
Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance
Koren, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, John C., Nguyen, Lana, Guo, Jianping, Blair, Laura J., Li, Xiaokai, Jinwal, Umesh K., Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Published in PloS one (10.07.2012)
Published in PloS one (10.07.2012)
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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Yarnall, Matthew T. N., Ioannidi, Eleonora I., Schmitt-Ulms, Cian, Krajeski, Rohan N., Lim, Justin, Villiger, Lukas, Zhou, Wenyuan, Jiang, Kaiyi, Garushyants, Sofya K., Roberts, Nathaniel, Zhang, Liyang, Vakulskas, Christopher A., Walker, John A., Kadina, Anastasia P., Zepeda, Adrianna E., Holden, Kevin, Ma, Hong, Xie, Jun, Gao, Guangping, Foquet, Lander, Bial, Greg, Donnelly, Sara K., Miyata, Yoshinari, Radiloff, Daniel R., Henderson, Jordana M., Ujita, Andrew, Abudayyeh, Omar O., Gootenberg, Jonathan S.
Published in Nature biotechnology (01.04.2023)
Published in Nature biotechnology (01.04.2023)
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Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver
Kato, Suguru, Shah, Abhi, Plesescu, Mihaela, Miyata, Yoshinari, Bolleddula, Jayaprakasam, Chowdhury, Swapan, Zhu, Xiaochun
Published in Drug metabolism and disposition (01.10.2020)
Published in Drug metabolism and disposition (01.10.2020)
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Journal Article
Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70
Miyata, Yoshinari, Rauch, Jennifer N., Jinwal, Umesh K., Thompson, Andrea D., Srinivasan, Sharan, Dickey, Chad A., Gestwicki, Jason E.
Published in Chemistry & biology (21.11.2012)
Published in Chemistry & biology (21.11.2012)
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Journal Article
Design, Synthesis, and Biological Evaluation of 4‑Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase
Madak, Joseph T, Cuthbertson, Christine R, Miyata, Yoshinari, Tamura, Shuzo, Petrunak, Elyse M, Stuckey, Jeanne A, Han, Yanyan, He, Miao, Sun, Duxin, Showalter, Hollis D, Neamati, Nouri
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Journal Article
Simultaneous measurement of mouse and human albumin in chimeric mice with humanized livers
Landry, France, Shen, Hong, Zhang, Yueping, Uchiyama, Asako, Miyata, Yoshinari, Morikawa, Yoshio, Joshi, Beth, Shipkova, Petia
Published in Bioanalysis (01.03.2022)
Published in Bioanalysis (01.03.2022)
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Journal Article
Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism
Chang, Lyra, Miyata, Yoshinari, Ung, Peter M.U., Bertelsen, Eric B., McQuade, Thomas J., Carlson, Heather A., Zuiderweg, Erik R.P., Gestwicki, Jason E.
Published in Chemistry & biology (25.02.2011)
Published in Chemistry & biology (25.02.2011)
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