Identification and characterization of a novel botulinum neurotoxin
Zhang, Sicai, Masuyer, Geoffrey, Zhang, Jie, Shen, Yi, Lundin, Daniel, Henriksson, Linda, Miyashita, Shin-Ichiro, Martínez-Carranza, Markel, Dong, Min, Stenmark, Pål
Published in Nature communications (03.08.2017)
Published in Nature communications (03.08.2017)
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Journal Article
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
Zhang, Sicai, Lebreton, Francois, Mansfield, Michael J., Miyashita, Shin-Ichiro, Zhang, Jie, Schwartzman, Julia A., Tao, Liang, Masuyer, Geoffrey, Martínez-Carranza, Markel, Stenmark, Pål, Gilmore, Michael S., Doxey, Andrew C., Dong, Min
Published in Cell host & microbe (14.02.2018)
Published in Cell host & microbe (14.02.2018)
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Journal Article
Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration
Shen, Yi, Wu, Sheng-Yi, Rancic, Vladimir, Aggarwal, Abhi, Qian, Yong, Miyashita, Shin-Ichiro, Ballanyi, Klaus, Campbell, Robert E, Dong, Min
Published in Communications biology (14.01.2019)
Published in Communications biology (14.01.2019)
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Journal Article
Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
Yin, Linxiang, Masuyer, Geoffrey, Zhang, Sicai, Zhang, Jie, Miyashita, Shin-Ichiro, Burgin, David, Lovelock, Laura, Coker, Shu-Fen, Fu, Tian-Min, Stenmark, Pål, Dong, Min
Published in PLoS biology (17.03.2020)
Published in PLoS biology (17.03.2020)
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Journal Article
Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins
Thaker, Hatim, Zhang, Jie, Miyashita, Shin-Ichiro, Cristofaro, Vivian, Park, SunHyun, Hashemi Gheinani, Ali, Sullivan, Maryrose P, Adam, Rosalyn M, Dong, Min
Published in PLoS pathogens (01.10.2021)
Published in PLoS pathogens (01.10.2021)
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Journal Article
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Tao, Liang, Tian, Songhai, Zhang, Jie, Liu, Zhuoming, Robinson-McCarthy, Lindsey, Miyashita, Shin-Ichiro, Breault, David T, Gerhard, Ralf, Oottamasathien, Siam, Whelan, Sean P J, Dong, Min
Published in Nature microbiology (01.10.2019)
Published in Nature microbiology (01.10.2019)
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Journal Article
Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A
Miyashita, Shin-Ichiro, Karatsu, Shura, Fujiishi, Mako, Huang, I Hsun, Nagashima, Yuki, Morobishi, Tamaki, Hosoya, Keita, Hata, Tsuyoshi, Dong, Min, Sagane, Yoshimasa
Published in Toxins (01.02.2023)
Published in Toxins (01.02.2023)
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Journal Article
"Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity
Miyashita, Shin-Ichiro, Sagane, Yoshimasa, Suzuki, Tomonori, Matsumoto, Takashi, Niwa, Koichi, Watanabe, Toshihiro
Published in Scientific reports (10.08.2016)
Published in Scientific reports (10.08.2016)
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Journal Article
Transport of the botulinum neurotoxin–associating protein, nontoxic nonhemagglutinin, across the rat small intestinal epithelial cell monolayer
Miyashita, Shin-Ichiro, Sagane, Yoshimasa, Niwa, Koichi, Watanabe, Toshihiro
Published in FEMS microbiology letters (01.09.2013)
Published in FEMS microbiology letters (01.09.2013)
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Journal Article
Small-angle X-ray scattering reveals structural dynamics of the botulinum neurotoxin associating protein, nontoxic nonhemagglutinin
Sagane, Yoshimasa, Miyashita, Shin-Ichiro, Miyata, Keita, Matsumoto, Takashi, Inui, Ken, Hayashi, Shintaro, Suzuki, Tomonori, Hasegawa, Kimiko, Yajima, Shunsuke, Yamano, Akihito, Niwa, Koichi, Watanabe, Toshihiro
Published in Biochemical and biophysical research communications (24.08.2012)
Published in Biochemical and biophysical research communications (24.08.2012)
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Journal Article
Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism
Miyashita, Shin-Ichiro, Zhang, Jie, Zhang, Sicai, Shoemaker, Charles B, Dong, Min
Published in Science translational medicine (06.01.2021)
Published in Science translational medicine (06.01.2021)
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Journal Article
Sugar-induced conformational change found in the HA-33/HA-17 trimer of the botulinum toxin complex
Sagane, Yoshimasa, Hayashi, Shintaro, Matsumoto, Takashi, Miyashita, Shin-Ichiro, Inui, Ken, Miyata, Keita, Yajima, Shunsuke, Suzuki, Tomonori, Hasegawa, Kimiko, Yamano, Akihito, Nishikawa, Atsushi, Ohyama, Tohru, Watanabe, Toshihiro, Niwa, Koichi
Published in Biochemical and biophysical research communications (30.08.2013)
Published in Biochemical and biophysical research communications (30.08.2013)
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Journal Article
Atomic force microscopic image data of botulinum neurotoxin complexes with different molecular sizes
Miyashita, Shin-Ichiro, Sagane, Yoshimasa, Uchino, Takamasa, Karatsu, Shura, Hosoya, Keita, Huang, Ihsun, Niwa, Koichi, Watanabe, Toshihiro, Niimura, Yoichi, Suzuki, Tomonori
Published in Data in brief (01.08.2019)
Published in Data in brief (01.08.2019)
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Journal Article
Toxic and nontoxic components of botulinum neurotoxin complex are evolved from a common ancestral zinc protein
Inui, Ken, Sagane, Yoshimasa, Miyata, Keita, Miyashita, Shin-Ichiro, Suzuki, Tomonori, Shikamori, Yasuyuki, Ohyama, Tohru, Niwa, Koichi, Watanabe, Toshihiro
Published in Biochemical and biophysical research communications (16.03.2012)
Published in Biochemical and biophysical research communications (16.03.2012)
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Journal Article
Massively parallel de novo protein design for targeted therapeutics
Chevalier, Aaron, Silva, Daniel-Adriano, Rocklin, Gabriel J, Hicks, Derrick R, Vergara, Renan, Murapa, Patience, Bernard, Steffen M, Zhang, Lu, Lam, Kwok-Ho, Yao, Guorui, Bahl, Christopher D, Miyashita, Shin-Ichiro, Goreshnik, Inna, Fuller, James T, Koday, Merika T, Jenkins, Cody M, Colvin, Tom, Carter, Lauren, Bohn, Alan, Bryan, Cassie M, Fernández-Velasco, D Alejandro, Stewart, Lance, Dong, Min, Huang, Xuhui, Jin, Rongsheng, Wilson, Ian A, Fuller, Deborah H, Baker, David
Published in Nature (London) (05.10.2017)
Published in Nature (London) (05.10.2017)
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Journal Article
Species-specific gene duplication in Clostridia produces variations of cholesterol-dependent cytolysin with different cytotoxicity
Hosoya, Keita, Miyashita, Shin-Ichiro, Karatsu, Shura, Huang, I-Hsun, Sagane, Yoshimasa
Published in Biochemical and biophysical research communications (31.12.2022)
Published in Biochemical and biophysical research communications (31.12.2022)
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Journal Article
Complete subunit structure of serotype C and D botulinum progenitor toxin complex induces vacuolation in the specific epithelial cell line
Huang, I-Hsun, Miyashita, Shin-Ichiro, Hata, Tsuyoshi, Karatsu, Shura, Hosoya, Keita, Sagane, Yoshimasa
Published in Biochemical and biophysical research communications (03.12.2022)
Published in Biochemical and biophysical research communications (03.12.2022)
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Journal Article
Identification of the interaction region between hemagglutinin components of the botulinum toxin complex
Suzuki, Tomonori, Miyashita, Shin-Ichiro, Hayashi, Shintaro, Miyata, Keita, Inui, Ken, Kondo, Yosuke, Miyazaki, Satoru, Ohyama, Tohru, Niwa, Koichi, Watanabe, Toshihiro, Sagane, Yoshimasa
Published in International journal of biological macromolecules (01.04.2014)
Published in International journal of biological macromolecules (01.04.2014)
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Journal Article
Botulinum Toxin Complex Increases Paracellular Permeability in Intestinal Epithelial Cells via Activation of p38 Mitogen-Activated Protein Kinase
MIYASHITA, Shin-ichiro, SAGANE, Yoshimasa, INUI, Ken, HAYASHI, Shintaro, MIYATA, Keita, SUZUKI, Tomonori, OHYAMA, Tohru, WATANABE, Toshihiro, NIWA, Koichi
Published in Journal of Veterinary Medical Science (2013)
Published in Journal of Veterinary Medical Science (2013)
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Journal Article