Evolution of a highly active and enantiospecific metalloenzyme from short peptides
Studer, Sabine, Hansen, Douglas A, Pianowski, Zbigniew L, Mittl, Peer R E, Debon, Aaron, Guffy, Sharon L, Der, Bryan S, Kuhlman, Brian, Hilvert, Donald
Published in Science (American Association for the Advancement of Science) (14.12.2018)
Published in Science (American Association for the Advancement of Science) (14.12.2018)
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Journal Article
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries
Kummer, Lutz, Parizek, Petra, Rube, Peter, Millgramm, Bastian, Prinz, Anke, Mittl, Peer R. E, Kaufholz, Melanie, Zimmermann, Bastian, Herberg, Friedrich W, Plückthun, Andreas
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2012)
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Journal Article
Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
Deluigi, Mattia, Morstein, Lena, Schuster, Matthias, Klenk, Christoph, Merklinger, Lisa, Cridge, Riley R., de Zhang, Lazarus A., Klipp, Alexander, Vacca, Santiago, Vaid, Tasneem M., Mittl, Peer R. E., Egloff, Pascal, Eberle, Stefanie A., Zerbe, Oliver, Chalmers, David K., Scott, Daniel J., Plückthun, Andreas
Published in Nature communications (19.01.2022)
Published in Nature communications (19.01.2022)
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Journal Article
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
Karakus, Ufuk, Sahin, Dilara, Mittl, Peer R E, Mooij, Petra, Koopman, Gerrit, Boyman, Onur
Published in Science translational medicine (16.12.2020)
Published in Science translational medicine (16.12.2020)
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Journal Article
Surface properties of Helicobacter pylori urease complex are essential for persistence
Schoep, Tobias D, Fulurija, Alma, Good, Fayth, Lu, Wei, Himbeck, Robyn P, Schwan, Carola, Choi, Sung Sook, Berg, Douglas E, Mittl, Peer R E, Benghezal, Mohammed, Marshall, Barry J
Published in PloS one (29.11.2010)
Published in PloS one (29.11.2010)
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Journal Article
Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme
Bunzel, H. Adrian, Kries, Hajo, Marchetti, Luca, Zeymer, Cathleen, Mittl, Peer R. E, Mulholland, Adrian J, Hilvert, Donald
Published in Journal of the American Chemical Society (31.07.2019)
Published in Journal of the American Chemical Society (31.07.2019)
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Journal Article
Precision is essential for efficient catalysis in an evolved Kemp eliminase
Blomberg, Rebecca, Kries, Hajo, Pinkas, Daniel M., Mittl, Peer R. E., Grütter, Markus G., Privett, Heidi K., Mayo, Stephen L., Hilvert, Donald
Published in Nature (London) (21.11.2013)
Published in Nature (London) (21.11.2013)
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Journal Article
Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population
Tschirren, Barbara, Andersson, Martin, Scherman, Kristin, Westerdahl, Helena, Mittl, Peer R. E., Råberg, Lars
Published in Proceedings of the Royal Society. B, Biological sciences (22.05.2013)
Published in Proceedings of the Royal Society. B, Biological sciences (22.05.2013)
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Journal Article
Design and optimization of enzymatic activity in a de novo β‐barrel scaffold
Kipnis, Yakov, Chaib, Anissa Ouald, Vorobieva, Anastassia A., Cai, Guangyang, Reggiano, Gabriella, Basanta, Benjamin, Kumar, Eshan, Mittl, Peer R.E., Hilvert, Donald, Baker, David
Published in Protein science (01.11.2022)
Published in Protein science (01.11.2022)
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Journal Article
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
Glögl, Matthias, Friedrich, Nikolas, Cerutti, Gabriele, Lemmin, Thomas, Kwon, Young D., Gorman, Jason, Maliqi, Liridona, Mittl, Peer R. E., Hesselman, Maria C., Schmidt, Daniel, Weber, Jacqueline, Foulkes, Caio, Dingens, Adam S., Bylund, Tatsiana, Olia, Adam S., Verardi, Raffaello, Reinberg, Thomas, Baumann, Nicolas S., Rusert, Peter, Dreier, Birgit, Shapiro, Lawrence, Kwong, Peter D., Plückthun, Andreas, Trkola, Alexandra
Published in Nature structural & molecular biology (01.09.2023)
Published in Nature structural & molecular biology (01.09.2023)
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Journal Article
Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes
Ogura, Masako, Perez, J Christian, Mittl, Peer R E, Lee, Hae-Kyung, Dailide, Geidrius, Tan, Shumin, Ito, Yoshiyuki, Secka, Ousman, Dailidiene, Daiva, Putty, Kalyani, Berg, Douglas E, Kalia, Awdhesh
Published in PLoS computational biology (01.08.2007)
Published in PLoS computational biology (01.08.2007)
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Journal Article
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection
Bieri, Manuela, Hendrickx, Rodinde, Bauer, Michael, Yu, Bin, Jetzer, Tania, Dreier, Birgit, Mittl, Peer R E, Sobek, Jens, Plückthun, Andreas, Greber, Urs F, Hemmi, Silvio
Published in PLoS pathogens (01.12.2021)
Published in PLoS pathogens (01.12.2021)
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Journal Article
Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity
Hansen, Simon, Tremmel, Dirk, Madhurantakam, Chaithanya, Reichen, Christian, Mittl, Peer R. E, Plückthun, Andreas
Published in Journal of the American Chemical Society (16.03.2016)
Published in Journal of the American Chemical Society (16.03.2016)
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