In Vitro Assessment of Potential for CYP-Inhibition-Based Drug–Drug Interaction Between Vonoprazan and Clopidogrel
Nishihara, Mitsuhiro, Yamasaki, Hitomi, Czerniak, Richard, Jenkins, Helen
Published in European journal of drug metabolism and pharmacokinetics (01.04.2019)
Published in European journal of drug metabolism and pharmacokinetics (01.04.2019)
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Evaluation of the pharmacokinetics of trazpiroben (TAK‐906) in the presence and absence of the proton pump inhibitor esomeprazole
Kaur Mukker, Jatinder, Dukes, George, Wang, Lisi, Huh, Susanna, Khudyakov, Polyna, Nishihara, Mitsuhiro, Chen, Chunlin
Published in Clinical and translational science (01.05.2022)
Published in Clinical and translational science (01.05.2022)
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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
Ohashi, Tomohiro, Oguro, Yuya, Tanaka, Toshio, Shiokawa, Zenyu, Tanaka, Yuta, Shibata, Sachio, Sato, Yoshihiko, Yamakawa, Hiroko, Hattori, Harumi, Yamamoto, Yukiko, Kondo, Shigeru, Miyamoto, Maki, Nishihara, Mitsuhiro, Ishimura, Yoshimasa, Tojo, Hideaki, Baba, Atsuo, Sasaki, Satoshi
Published in Bioorganic & medicinal chemistry (15.09.2012)
Published in Bioorganic & medicinal chemistry (15.09.2012)
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The pharmacokinetics of oral trazpiroben (TAK‐906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study
Mukker, Jatinder K., Dukes, George, Tolkoff, Max, Wang, Lisi, Almansa, Cristina, Huh, Susanna Y., Nishihara, Mitsuhiro, Ramsden, Diane, Chen, Chunlin
Published in Clinical and translational science (01.06.2022)
Published in Clinical and translational science (01.06.2022)
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The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent
Stringer, Frances, Scott, Graham, Valbuena, Marian, Kinley, Judith, Nishihara, Mitsuhiro, Urquhart, Richard
Published in European journal of clinical pharmacology (01.03.2013)
Published in European journal of clinical pharmacology (01.03.2013)
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UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B152 Mutation
Nishihara, Mitsuhiro, Hiura, Yuto, Kawaguchi, Naohiro, Takahashi, Junzo, Asahi, Satoru
Published in DRUG METABOLISM AND PHARMACOKINETICS (2013)
Published in DRUG METABOLISM AND PHARMACOKINETICS (2013)
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An unusual metabolic pathway of sipoglitazar, a novel antidiabetic agent: cytochrome P450-catalyzed oxidation of sipoglitazar acyl glucuronide
Nishihara, Mitsuhiro, Sudo, Miyako, Kawaguchi, Naohiro, Takahashi, Junzo, Kiyota, Yutaka, Kondo, Takahiro, Asahi, Satoru
Published in Drug metabolism and disposition (01.02.2012)
Published in Drug metabolism and disposition (01.02.2012)
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Metabolic Fate of Sipoglitazar a Novel Oral PPAR Agonist with Activities for PPAR-γ, -α and -δ, in Rats and Monkeys and Comparison with Humans In Vitro
Nishihara, Mitsuhiro, Sudo, Miyako, Kamiguchi, Hidenori, Kawaguchi, Naohiro, Maeshiba, Yoshihiro, Kiyota, Yutaka, Takahashi, Junzo, Tagawa, Yoshihiko, Kondo, Takahiro, Asahi, Satoru
Published in Drug metabolism and pharmacokinetics (2012)
Published in Drug metabolism and pharmacokinetics (2012)
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Metabolic Fate of Sipoglitazar, a Novel Oral PPAR Agonist with Activities for PPAR-γ,-α and -δ, in Rats and Monkeys and Comparison with Humans In Vitro
Mitsuhiro NISHIHARA, Miyako SUDO, Hidenori KAMIGUCHI, Naohiro KAWAGUCHI, Yoshihiro MAESHIBA, Yutaka KIYOTA, Junzo TAKAHASHI, Yoshihiko TAGAWA, Takahiro KONDO, Satoru ASAHI
Published in DRUG METABOLISM AND PHARMACOKINETICS (25.04.2012)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (25.04.2012)
Journal Article
Drug-Drug Interaction by CYP Metabolism Is Not a Major Determinant of Attenuation of Anti-platelet Function of Clopidogrel by Coadministration with Vonoprazan
Nishihara, Mitsuhiro, Yamasaki, Hitomi, Czerniak, Richard, Jenkins, Helen
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
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Long-Term Stability of Cryopreserved Human Hepatocytes: Evaluation of Phase I and II Drug-Metabolizing Enzyme Activities and CYP3A4/5 Induction for More than a Decade
Sudo, Miyako, Nishihara, Mitsuhiro, Takahashi, Junzo, Asahi, Satoru
Published in Drug metabolism and disposition (01.07.2017)
Published in Drug metabolism and disposition (01.07.2017)
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Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK‐272 (SCO‐272), a novel orally active renin inhibitor
Ebihara, Takuya, Nishihara, Mitsuhiro, Takahashi, Junzo, Jinno, Fumihiro, Tagawa, Yoshihiko
Published in Biopharmaceutics & drug disposition (01.03.2018)
Published in Biopharmaceutics & drug disposition (01.03.2018)
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Crystal Structures of Reaction Intermediates ofl-2-Haloacid Dehalogenase and Implications for the Reaction Mechanism
Li, Yong-Fu, Hata, Yasuo, Fujii, Tomomi, Hisano, Tamao, Nishihara, Mitsuhiro, Kurihara, Tatsuo, Esaki, Nobuyoshi
Published in The Journal of biological chemistry (12.06.1998)
Published in The Journal of biological chemistry (12.06.1998)
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Paracatalytic Inactivation of L-2-Haloacid Dehalogenase from Pseudomonas sp. YL by Hydroxylamine
Liu, Ji-Quan, Kurihara, Tatsuo, Miyagi, Masaru, Tsunasawa, Susumu, Nishihara, Mitsuhiro, Esaki, Nobuyoshi, Soda, Kenji
Published in The Journal of biological chemistry (07.02.1997)
Published in The Journal of biological chemistry (07.02.1997)
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Abstract 4508: Nonclinical pharmacokinetics of TAK-441, a hedgehog pathway inhibitor
Tohyama, Kimio, Yamasaki, Hitomi, Takeuchi, Toshiyuki, Nishihara, Mitsuhiro, Cohen, Lawrence, Tagawa, Yoshihiko, Takahashi, Junzo, Asahi, Satoru
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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