Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
Martinez-Zapien, Denise, Ruiz, Francesc Xavier, Poirson, Juline, Mitschler, André, Ramirez, Juan, Forster, Anne, Cousido-Siah, Alexandra, Masson, Murielle, Pol, Scott Vande, Podjarny, Alberto, Travé, Gilles, Zanier, Katia
Published in Nature (London) (28.01.2016)
Published in Nature (London) (28.01.2016)
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Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation
Conrady, Marcel Chris, Suarez, Irina, Gogl, Gergö, Frecot, Desiree Isabella, Bonhoure, Anna, Kostmann, Camille, Cousido-Siah, Alexandra, Mitschler, André, Lim, JiaWen, Masson, Murielle, Iftner, Thomas, Stubenrauch, Frank, Travé, Gilles, Simon, Claudia
Published in Journal of virology (22.12.2020)
Published in Journal of virology (22.12.2020)
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Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase
Crespo, Isidro, Giménez-Dejoz, Joan, Porté, Sergio, Cousido-Siah, Alexandra, Mitschler, André, Podjarny, Alberto, Pratsinis, Harris, Kletsas, Dimitris, Parés, Xavier, Ruiz, Francesc X., Metwally, Kamel, Farrés, Jaume
Published in European journal of medicinal chemistry (25.05.2018)
Published in European journal of medicinal chemistry (25.05.2018)
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Journal Article
Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition
Howard, Eduardo, Cousido‐Siah, Alexandra, Lepage, Mathieu L., Schneider, Jérémy P., Bodlenner, Anne, Mitschler, André, Meli, Alessandra, Izzo, Irene, Alvarez, H. Ariel, Podjarny, Alberto, Compain, Philippe
Published in Angewandte Chemie International Edition (02.07.2018)
Published in Angewandte Chemie International Edition (02.07.2018)
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Journal Article
High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression
Poirson, Juline, Suarez, Irina Paula, Straub, Marie-Laure, Cousido-Siah, Alexandra, Peixoto, Paul, Hervouet, Eric, Foster, Anne, Mitschler, André, Mukobo, Noella, Chebaro, Yassmine, Garcin, Dominique, Recberlik, Sevda, Gaiddon, Christian, Altschuh, Danièle, Nominé, Yves, Podjarny, Alberto, Trave, Gilles, Masson, Murielle
Published in Journal of virology (25.05.2022)
Published in Journal of virology (25.05.2022)
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Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
Van Zandt, Michael C, Jagdmann, G. Erik, Whitehouse, Darren L, Ji, Minkoo, Savoy, Jennifer, Potapova, Olga, Cousido-Siah, Alexandra, Mitschler, Andre, Howard, Eduardo I, Pyle, Anna Marie, Podjarny, Alberto D
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Conformational editing of intrinsically disordered protein by α-methylation
Bauer, Valentin, Schmidtgall, Boris, Gógl, Gerg, Dolenc, Jozica, Osz, Judit, Nominé, Yves, Kostmann, Camille, Cousido-Siah, Alexandra, Mitschler, André, Rochel, Natacha, Travé, Gilles, Kieffer, Bruno, Torbeev, Vladimir
Published in Chemical science (Cambridge) (28.01.2021)
Published in Chemical science (Cambridge) (28.01.2021)
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Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5
Timucin, Emel, Cousido-Siah, Alexandra, Mitschler, André, Podjarny, Alberto, Sezerman, Osman Ugur
Published in Proteins, structure, function, and bioinformatics (01.01.2016)
Published in Proteins, structure, function, and bioinformatics (01.01.2016)
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Journal Article
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
Moras, Dino, Billas, Isabelle M. L, Iwema, Thomas, Garnier, Jean-Marie, Mitschler, André, Rochel, Natacha
Published in Nature (06.11.2003)
Published in Nature (06.11.2003)
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Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10
Klein, Fabrice A C, Zeder-Lutz, Gabrielle, Cousido-Siah, Alexandra, Mitschler, André, Katz, Aline, Eberling, Pascal, Mandel, Jean-Louis, Podjarny, Alberto, Trottier, Yvon
Published in Human molecular genetics (15.10.2013)
Published in Human molecular genetics (15.10.2013)
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New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
Fadel, Firas, Zhao, Yuguang, Cachau, Raul, Cousido-Siah, Alexandra, Ruiz, Francesc X., Harlos, Karl, Howard, Eduardo, Mitschler, Andre, Podjarny, Alberto
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2015)
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Journal Article
Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design
Cousido-Siah, Alexandra, Ruiz, Francesc X., Mitschler, André, Porté, Sergio, de Lera, Ángel R., Martín, María J., Manzanaro, Sonia, de la Fuente, Jesús A., Terwesten, Felix, Betz, Michael, Klebe, Gerhard, Farrés, Jaume, Parés, Xavier, Podjarny, Alberto
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2014)
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Journal Article
Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10
Cousido-Siah, Alexandra, Ruiz, Francesc X., Crespo, Isidro, Porté, Sergio, Mitschler, André, Parés, Xavier, Podjarny, Alberto, Farrés, Jaume
Published in Chemico-biological interactions (05.06.2015)
Published in Chemico-biological interactions (05.06.2015)
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Journal Article
Neutron macromolecular crystallography with LADI-III
Blakeley, Matthew P., Teixeira, Susana C. M., Petit-Haertlein, Isabelle, Hazemann, Isabelle, Mitschler, Andre, Haertlein, Michael, Howard, Eduardo, Podjarny, Alberto D.
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2010)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2010)
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Journal Article
Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants
Noguera, Martín E., Vazquez, Diego S., Ferrer-Sueta, Gerardo, Agudelo, William A., Howard, Eduardo, Rasia, Rodolfo M., Manta, Bruno, Cousido-Siah, Alexandra, Mitschler, André, Podjarny, Alberto, Santos, Javier
Published in Scientific reports (09.02.2017)
Published in Scientific reports (09.02.2017)
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Journal Article
Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
Ruiz, Francesc X., Crespo, Isidro, Álvarez, Susana, Porté, Sergio, Giménez-Dejoz, Joan, Cousido-Siah, Alexandra, Mitschler, André, de Lera, Ángel R., Parés, Xavier, Podjarny, Alberto, Farrés, Jaume
Published in Chemico-biological interactions (01.10.2017)
Published in Chemico-biological interactions (01.10.2017)
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Journal Article
Molecular Recognition of Agonist Ligands by RXRs
Egea, Pascal F, Mitschler, André, Moras, Dino
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
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Journal Article
The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
Valsecchi, Wanda M., Cousido-Siah, Alexandra, Defelipe, Lucas A., Mitschler, André, Podjarny, Alberto, Santos, Javier, Delfino, José M.
Published in Biochimica et biophysica acta (01.06.2016)
Published in Biochimica et biophysica acta (01.06.2016)
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Journal Article
Crystal packing modifies ligand binding affinity: The case of aldose reductase
Cousido-Siah, Alexandra, Petrova, Tatiana, Hazemann, Isabelle, Mitschler, André, Ruiz, Francesc X., Howard, Eduardo, Ginell, Stephan, Atmanene, Cédric, Van Dorsselaer, Alain, Sanglier-Cianférani, Sarah, Joachimiak, Andrzej, Podjarny, Alberto
Published in Proteins, structure, function, and bioinformatics (01.11.2012)
Published in Proteins, structure, function, and bioinformatics (01.11.2012)
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