Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state
Lombardo, Franco, Waters, Nigel J, Argikar, Upendra A, Dennehy, Michelle K, Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P, Berellini, Giuliano, Rajlic, Ivana Liric, Obach, R Scott
Published in Journal of clinical pharmacology (01.02.2013)
Published in Journal of clinical pharmacology (01.02.2013)
Get more information
Journal Article
Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance
Lombardo, Franco, Waters, Nigel J, Argikar, Upendra A, Dennehy, Michelle K, Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P, Berellini, Giuliano, Liric Rajlic, Ivana, Obach, R Scott
Published in Journal of clinical pharmacology (01.02.2013)
Published in Journal of clinical pharmacology (01.02.2013)
Get more information
Journal Article
In vitro investigation of catabolism and metabolism of antibody drug conjugates (ADCS)
Gunduz, Mithat, Cirello, Amanda L., Dumouchel, Jennifer L., Hainzl, Dominik, D'Alessio, Tony, Bialucha, Carl, Capka, Vladimir, Argikar, Upendra A.
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Get full text
Journal Article
Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement
Gunduz, Mithat, Cirello, Amanda L, Klimko, Peter, Dumouchel, Jennifer L, Argikar, Upendra A
Published in Drug metabolism letters (01.06.2017)
Published in Drug metabolism letters (01.06.2017)
Get more information
Journal Article
Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat
Dumouchel, Jennifer L, Argikar, Upendra A, Spear, Jaimie, Brown, Ann, Dunne, Christine E, Kramlinger, Valerie M, Cirello, Amanda L, Gunduz, Mithat
Published in Drug metabolism letters (01.06.2017)
Published in Drug metabolism letters (01.06.2017)
Get more information
Journal Article
New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation
Gunduz, Mithat, Argikar, Upendra A, Cirello, Amanda L, Dumouchel, Jennifer L
Published in Drug metabolism letters (2018)
Published in Drug metabolism letters (2018)
Get more information
Journal Article
BIOTRANSFORMATION OF A GABAA RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES
SHAFFER, Christopher L, GUNDUZ, Mithat, O'CONNELL, Thomas N, OBACH, R. Scott, YEE, Shiyin
Published in Drug metabolism and disposition (01.11.2005)
Published in Drug metabolism and disposition (01.11.2005)
Get full text
Journal Article
Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations
He, Minxia Michelle, Zhu, Sean Xiaochun, Cannon, Joe R., Christensen, Jesper Kammersgaard, Duggal, Ruchia, Gunduz, Mithat, Hilgendorf, Constanze, Hughes, Adam, Kekessie, Ivy, Kullmann, Maximilian, Leung, Dennis, Terjung, Carsten, Wang, Kai, Wesche, Frank
Published in Drug metabolism and disposition (01.11.2023)
Published in Drug metabolism and disposition (01.11.2023)
Get full text
Journal Article
Metabolism and excretion of therapeutic peptides: current industry practices and recommendations
He, Minxia, Zhu, Xiaochun (Sean), Cannon, Joe, Christensen, Jesper, Duggal, Ruchia, Gunduz, Mithat, Hilgendorf, Constanze, Hughes, Adam, Kekessie, Ivy, Leung, Dennis, Terjung, Carsten, Wang, Kai
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Get full text
Journal Article
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation
Pearson, David, Jin, Yi, Romeo, Andrea, Birlinger, Bertrand-Luc, Schiller, Hilmar, Ji, Yan, Gunduz, Mithat, Baldoni, Daniela, Walles, Markus
Published in Xenobiotica (02.01.2022)
Published in Xenobiotica (02.01.2022)
Get full text
Journal Article
Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
Dumouchel, Jennifer L, Chemuturi, Nagendra, Milton, Mark N, Camenisch, Gian, Chastain, James, Walles, Markus, Sasseville, Vito, Gunduz, Mithat, Iyer, Ganesh R, Argikar, Upendra A
Published in Drug metabolism and disposition (01.11.2018)
Published in Drug metabolism and disposition (01.11.2018)
Get full text
Journal Article
Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?
Argikar, Upendra A., Dumouchel, Jennifer L., Kramlinger, Valerie M., Cirello, Amanda L., Gunduz, Mithat, Dunne, Christine E., Sohal, Bindi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
Get full text
Journal Article
Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate
Gunduz, Mithat, Argikar, Upendra A, Kamel, Amin, Colizza, Kevin, Bushee, Jennifer L, Cirello, Amanda, Lombardo, Franco, Harriman, Shawn
Published in Drug metabolism and disposition (01.11.2012)
Published in Drug metabolism and disposition (01.11.2012)
Get full text
Journal Article
In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase
Kamel, Amin, Colizza, Kevin, Gunduz, Mithat, Harriman, Shawn, Obach, R. Scott
Published in Xenobiotica (01.04.2012)
Published in Xenobiotica (01.04.2012)
Get full text
Journal Article
Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition
Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder, Thomas N. O'Connell
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
Get full text
Journal Article