A mechanism for CO regulation of ion channels
Kapetanaki, Sofia M., Burton, Mark J., Basran, Jaswir, Uragami, Chiasa, Moody, Peter C. E., Mitcheson, John S., Schmid, Ralf, Davies, Noel W., Dorlet, Pierre, Vos, Marten H., Storey, Nina M., Raven, Emma
Published in Nature communications (02.03.2018)
Published in Nature communications (02.03.2018)
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A heme-binding domain controls regulation of ATP-dependent potassium channels
Burton, Mark J., Kapetanaki, Sofia M., Chernova, Tatyana, Jamieson, Andrew G., Dorlet, Pierre, Santolini, Jérôme, Moody, Peter C. E., Mitcheson, John S., Davies, Noel W., Schmid, Ralf, Raven, Emma L., Storey, Nina M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
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Journal Article
Molecular Determinants of hERG Channel Block
Kamiya, Kaichiro, Niwa, Ryoko, Mitcheson, John S, Sanguinetti, Michael C
Published in Molecular pharmacology (01.05.2006)
Published in Molecular pharmacology (01.05.2006)
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Journal Article
hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine
Melgari, Dario, Brack, Kieran E, Zhang, Chuan, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S, Dempsey, Christopher E, Ng, G André, Hancox, Jules C
Published in Journal of the American Heart Association (24.04.2015)
Published in Journal of the American Heart Association (24.04.2015)
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A Structural Basis for Drug-Induced Long QT Syndrome
Mitcheson, John S., Chen, Jun, Lin, Monica, Culberson, Chris, Sanguinetti, Michael C.
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2000)
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Journal Article
Author Correction: A mechanism for CO regulation of ion channels
Kapetanaki, Sofia M., Burton, Mark J., Basran, Jaswir, Uragami, Chiasa, Moody, Peter C. E., Mitcheson, John S., Schmid, Ralf, Davies, Noel W., Dorlet, Pierre, Vos, Marten H., Storey, Nina M., Raven, Emma
Published in Nature communications (17.08.2018)
Published in Nature communications (17.08.2018)
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Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Perry, Matthew, Stansfeld, Phillip J, Leaney, Joanne, Wood, Claire, de Groot, Marcel J, Leishman, Derek, Sutcliffe, Michael J, Mitcheson, John S
Published in Molecular pharmacology (01.02.2006)
Published in Molecular pharmacology (01.02.2006)
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Journal Article
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
Mitcheson, J S, Chen, J, Sanguinetti, M C
Published in The Journal of general physiology (01.03.2000)
Published in The Journal of general physiology (01.03.2000)
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Journal Article
Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain
Muskett, Frederick W., Thouta, Samrat, Thomson, Steven J., Bowen, Alexander, Stansfeld, Phillip J., Mitcheson, John S.
Published in The Journal of biological chemistry (25.02.2011)
Published in The Journal of biological chemistry (25.02.2011)
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Journal Article
Predicting drug–hERG channel interactions that cause acquired long QT syndrome
Sanguinetti, Michael C., Mitcheson, John S.
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2005)
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2005)
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Journal Article
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
Burton, Mark J., Cresser-Brown, Joel, Thomas, Morgan, Portolano, Nicola, Basran, Jaswir, Freeman, Samuel L., Kwon, Hanna, Bottrill, Andrew R., Llansola-Portoles, Manuel J., Pascal, Andrew A., Jukes-Jones, Rebekah, Chernova, Tatyana, Schmid, Ralf, Davies, Noel W., Storey, Nina M., Dorlet, Pierre, Moody, Peter C.E., Mitcheson, John S., Raven, Emma L.
Published in The Journal of biological chemistry (18.09.2020)
Published in The Journal of biological chemistry (18.09.2020)
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Journal Article
Correction: Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
Burton, Mark J., Cresser-Brown, Joel, Thomas, Morgan, Portolano, Nicola, Basran, Jaswir, Freeman, Samuel L., Kwon, Hanna, Bottrill, Andrew R., Llansola-Portoles, Manuel J., Pascal, Andrew A., Jukes-Jones, Rebekah, Chernova, Tatyana, Schmid, Ralf, Davies, Noel W., Storey, Nina M., Dorlet, Pierre, Moody, Peter C.E., Mitcheson, John S., Raven, Emma L.
Published in The Journal of biological chemistry (01.03.2022)
Published in The Journal of biological chemistry (01.03.2022)
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New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity
Gasparoli, Luca, D'Amico, Massimo, Masselli, Marika, Pillozzi, Serena, Caves, Rachel, Khuwaileh, Rawan, Tiedke, Wolfgang, Mugridge, Kenneth, Pratesi, Alessandro, Mitcheson, John S, Basso, Giuseppe, Becchetti, Andrea, Arcangeli, Annarosa
Published in Molecular pharmacology (01.02.2015)
Published in Molecular pharmacology (01.02.2015)
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Journal Article
Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain
Lörinczi, Eva, Helliwell, Matthew, Finch, Alina, Stansfeld, Phillip J., Davies, Noel W., Mahaut-Smith, Martyn, Muskett, Frederick W., Mitcheson, John S.
Published in The Journal of biological chemistry (19.08.2016)
Published in The Journal of biological chemistry (19.08.2016)
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